2021
Sloand JN, Rokni E, Watson CT, Miller MA, Manning KB, Simon JC, Medina SH. Ultrasound-Responsive Nanopeptisomes Enable Synchronous Spatial Imaging and Inhibition of Clot Growth in Deep Vein Thrombosis. Advanced Healthcare Materials. e2100520. PMID 34137205 DOI: 10.1002/adhm.202100520
Yang L, Tobin N, Manning KB. Refining a numerical model for device-induced thrombosis and investigating the effects of non-Newtonian blood models. Journal of Biomechanics. 120: 110393. PMID 33784516 DOI: 10.1016/j.jbiomech.2021.110393
Ponnaluri SV, Deutsch S, Sacks MS, Manning KB. Transcatheter Heart Valve Downstream Fluid Dynamics in an Accelerated Evaluation Environment. Annals of Biomedical Engineering. PMID 33638029 DOI: 10.1007/s10439-021-02751-w
Manning KB, Deutsch S, Rosenberg G. John M. Tarbell: Artificial Heart and Mechanical Heart Valve Research Contributions. Cardiovascular Engineering and Technology. PMID 33409858 DOI: 10.1007/s13239-020-00510-x
2020
Good BC, Costanzo F, Simon SD, Manning KB. Hydrodynamics in Acute Ischemic Stroke Catheters Under Static and Cyclic Aspiration Conditions. Cardiovascular Engineering and Technology. PMID 33210259 DOI: 10.1007/s13239-020-00503-w
Jhun CS, Newswanger R, Cysyk JP, Ponnaluri S, Good B, Manning KB, Rosenberg G. Dynamics of Blood Flows in Aortic Stenosis: Mild, Moderate, and Severe. Asaio Journal (American Society For Artificial Internal Organs : 1992). PMID 33164999 DOI: 10.1097/MAT.0000000000001296
Yang L, Neuberger T, Manning KB. In vitro real-time magnetic resonance imaging for quantification of thrombosis. Magma (New York, N.Y.). PMID 32729094 DOI: 10.1007/S10334-020-00872-2
Tobin N, Manning KB. Large-Eddy Simulations of Flow in the FDA Benchmark Nozzle Geometry to Predict Hemolysis. Cardiovascular Engineering and Technology. PMID 32297154 DOI: 10.1007/S13239-020-00461-3
Good BC, Manning K. Computational Modeling of the Food and Drug Administration’s Benchmark Centrifugal Blood Pump. Artificial Organs.
2019
Good BC, Simon S, Manning K, Costanzo F. Development of a computational model for acute ischemic stroke recanalization through cyclic aspiration. Biomechanics and modeling in mechanobiology. 2019 Nov 4:1-8.
2018
Craven BA, Aycock KI, Manning KB. Steady Flow in a Patient-Averaged Inferior Vena Cava—Part II: Computational Fluid Dynamics Verification and Validation. Cardiovascular engineering and technology. 2018 Dec; 9 (4), 654-673. doi:10.1007/s13239-018-00392-0. Epub 2018 Nov 16.
Hariharan P, Aycock KI, Buesen M, Day SW, Good BC, Herbertson LH, Steinseifer U, Manning KB, Craven BA, Malinauskas RA. Inter-laboratory characterization of the velocity field in the FDA blood pump model using particle image velocimetry (PIV). Cardiovascular engineering and technology. 2018 Dec. 9 (4), 623-640. doi: 10.1007/s13239-018-00378-y. Epub 2018 Oct 05.
Gallagher MB, Aycock KI, Craven BA, Manning KB. Steady flow in a patient-averaged inferior vena cava—part I: particle image velocimetry measurements at rest and exercise conditions. Cardiovascular engineering and technology. 2018 Dec. 9 (4), 641-653. doi: 10.1007/s13239-018-00390-2. Epub 2018 Nov 08.
Rosenberg G, Siedlecki CA, Jhun CS, Weiss WJ, Manning KB, Deutsch S, Pierce W. Acquired Von Willebrand Syndrome and Blood Pump Design. Artificial organs. 2018 Dec. 42 (12), 1119-1124. doi: 10.1111/aor.13291.
Rowlands GW, Good BC, Deutsch S, Manning KB. Characterizing the HeartMate II Left Ventricular Assist Device outflow using particle image velocimetry. Journal of biomechanical engineering. 2018 Jul. 140 (7), 071008. doi: 10.1115/1.4039822. Epub 2018 Apr 30.
Tedaldi E, Montanari C, Aycock KI, Sturla F, Redaelli A, Manning KB. An experimental and computational study of the inferior vena cava hemodynamics under respiratory-induced collapse of the infrarenal IVC. Medical engineering & physics. 2018 Apr. 54, 44-55. doi: 10.1016/j.medengphy.2018.02.003. Epub 2018 Mar 02.
2017
Aycock KI, Campbell RL, Lynch FC, Manning KB, Craven BA. Computational predictions of the embolus-trapping performance of an IVC filter in patient-specific and idealized IVC geometries. Biomechanics and modeling in mechanobiology. 2017 Dec; 16 (6), 1957-1969. doi: 10.1007/s10237-017-0931-5. Epub 2017 Jun 27.
Aycock KI, Campbell RL, Manning KB, Craven BA. A resolved two-way coupled CFD/6-DOF approach for predicting embolus transport and the embolus-trapping efficiency of IVC filters. Biomechanics and modeling in mechanobiology. 2017 Jun; 16 (3), 851-869. doi: 10.1007/s10237-016-0857-3. Epub 2016 Nov 30.
Malinauskas RA, Hariharan P, Day, SW, Herbertson LH, Buesen M, Steinseifer U, Aycock KI, Good BC, Deutsch S, Manning KB, Craven BA. FDA benchmark medical device flow models for CFD validation. Asaio Journal. 2017 Mar; 63 (2), 150-160. doi: 10.1097/MAT.0000000000000499
Taylor JO, Yang L, Deutsch S, Manning KB. Development of a platelet adhesion transport equation for a computational thrombosis model. Journal of biomechanics. 2017 Jan; 50, 114-120. doi:10.1016/j.jbiomech.2016.11.012. Epub 2016 Nov 10.
2016
Aycock KI, Campbell RL, Lynch FC, Manning KB, Craven BA. The Importance of Hemorheology and Anatomy on the Hemodynamics in the Inferior Vena Cava. Ann Biomed Eng. 2016 Jun 6.
Taylor JO, Meyer RS, Deutsch S, Manning KB. Development of a computational model for macroscopic predictions of device-induced thrombosis. Biomech Model Mechanobiol. 2016 May 12.
Good BC, Deutsch S, Manning KB. Continuous and pulsatile pediatric ventricular assist device hemodynamics with a viscoelastic blood model. Cardiovasc Eng Technol. 2016 Mar;7(1):23-43. doi: 10.1007/s13239-015-0252-8. Epub 2015 Dec 7.
Good BC, Deutsch S, Manning KB. Hemodynamics in a pediatric ascending aorta using a viscoelastic pediatric blood model. Ann Biomed Eng. 2016 Apr;44(4):1019-35. doi: 10.1007/s10439-015-1370-z. Epub 2015 Jul 10.
Taylor JO, Good BC, Paterno AV, Hariharan P, Deutsch S, Malinauskas RA, Manning KB. Analysis of transitional and turbulent flow through the FDA benchmark nozzle model using laser Doppler velocimetry. Cardiovascular engineering and technology 2016, Sept; 7 (3), 191-209. doi:/10.1007/s13239-016-0270-1. Epub 2016 Jan 27.
2015
de Biasi AR, Manning KB, Salemi A. Time to cool off on a hot topic? Let’s not forget about evidence when discussing heat-induced pump thrombogenesis. J Heart Lung Transplant. 2015 Apr;34(4):623-4. doi: 10.1016/j.healun.2014.12.018. Epub 2014 Dec 23.
de Biasi AR, Manning KB, Salemi A. Science for surgeons: understanding pump thrombogenesis in continuous-flow left ventricular assist devices. J Thorac Cardiovasc Surg. 2015 Mar;149(3):667-73. doi: 10.1016/j.jtcvs.2014.11.041. Epub 2014 Nov 21.
2014
Masoumi N, Annabi N, Assmann A, Larson BL, Hjortnaes J, Alemdar N, Kharaziha M, Manning KB, Mayer JE Jr, Khademhosseini A. Tri-layered elastomeric scaffolds for engineering heart valve leaflets. Biomaterials. 2014 Sep;35(27):7774-85. doi: 10.1016/j.biomaterials.2014.04.039. Epub 2014 Jun 16.
Taylor JO, Witmer KP, Neuberger T, Craven BA, Meyer RS, Deutsch S, Manning KB. In vitro quantification of time dependent thrombus size using magnetic resonance imaging and computational simulations of thrombus surface shear stresses. J Biomech Eng. 2014 Jul;136(7). doi: 10.1115/1.4027613.
Aycock KI, Campbell RL, Manning KB, Sastry SP, Shontz SM, Lynch FC, Craven BA. A computational method for predicting inferior vena cava filter performance on a patient-specific basis. J Biomech Eng. 2014 Aug;136(8). doi: 10.1115/1.4027612. Erratum in: J Biomech Eng. 2015 Nov;137(11):117001.
Navitsky MA, Taylor JO, Smith AB, Slattery MJ, Deutsch S, Siedlecki CA, Manning KB. Platelet adhesion to polyurethane urea under pulsatile flow conditions. Artif Organs. 2014 Dec;38(12):1046-53. doi: 10.1111/aor.12296. Epub 2014 Apr 9.
Topper SR, Navitsky MA, Medvitz RB, Paterson EG, Siedlecki CA, Slattery MJ, Deutsch S, Rosenberg G, Manning KB. The Use of Fluid Mechanics to Predict Regions of Microscopic Thrombus Formation in Pulsatile VADs. Cardiovasc Eng Technol. 2014 Mar 1;5(1):54-69.
Masoumi N, Larson BL, Annabi N, Kharaziha M, Zamanian B, Shapero KS, Cubberley AT, Camci-Unal G, Manning KB, Mayer JE Jr, Khademhosseini A. Electrospun PGS:PCL microfibers align human valvular interstitial cells and provide tunable scaffold anisotropy. Adv Healthc Mater. 2014 Jun;3(6):929-39. doi: 10.1002/adhm.201300505. Epub 2014 Jan 22.
2013
Navitsky MA, Deutsch S, Manning KB. A thrombus susceptibility comparison of two pulsatile Penn State 50 cc left ventricular assist device designs. Ann Biomed Eng. 2013 Jan;41(1):4-16. doi: 10.1007/s10439-012-0627-z. Epub 2012 Jul 24.
2012
Schönberger M, Deutsch S, Manning KB. The influence of device position on the flow within the Penn State 12 cc pediatric ventricular assist device. ASAIO J. 2012 Sep-Oct;58(5):481-93. doi: 10.1097/MAT.0b013e3182639a18.
Long TC, Pearson JJ, Hankinson AC, Deutsch S, Manning KB. An in vitro fluid dynamic study of pediatric cannulae: the value of animal studies to predict human flow. J Biomech Eng. 2012 Apr;134(4):044501. doi: 10.1115/1.4006428.
2011
Nanna JC, Navitsky MA, Topper SR, Deutsch S, Manning KB. A fluid dynamics study in a 50 cc pulsatile ventricular assist device: influence of heart rate variability. J Biomech Eng. 2011 Oct;133(10):101002. doi: 10.1115/1.4005001.
Herbertson LH, Deutsch S, Manning KB. Near valve flows and potential blood damage during closure of a bileaflet mechanical heart valve. J Biomech Eng. 2011 Sep;133(9):094507. doi: 10.1115/1.4005167.
Zapanta CM, Borovetz HS, Lysaght MJ, Manning KB. How to teach artificial organs. ASAIO J. 2011 Sep-Oct;57(5):466-9. doi: 10.1097/MAT.0b013e31823005f0.
Nanna JC, Wivholm JA, Deutsch S, Manning KB. Flow field study comparing design iterations of a 50 cc left ventricular assist device. ASAIO J. 2011 Sep-Oct;57(5):349-57. doi: 10.1097/MAT.0b013e318224e20b.
Hariharan P, Giarra M, Reddy V, Day SW, Manning KB, Deutsch S, Stewart SF, Myers MR, Berman MR, Burgreen GW, Paterson EG, Malinauskas RA. Multilaboratory particle image velocimetry analysis of the FDA benchmark nozzle model to support validation of computational fluid dynamics simulations. J Biomech Eng. 2011 Apr;133(4):041002. doi: 10.1115/1.4003440.
2007
Medvitz RB, Kreider JW, Manning KB, Fontaine AA, Deutsch S, Paterson EG.Development and validation of a computational fluid dynamics methodology for simulation of pulsatile left ventricular assist devices.ASAIO J. 2007 Mar-Apr;53(2):122-31.
2006
Kreider JW, Manning KB, Oley LA, Fontaine AA, Deutsch S. The 50cc Penn State left ventricular assist device: a parametric study of valve orientation flow dynamics. ASAIO J. 2006 Mar-Apr;52(2):123-31.
Herbertson LH, Reddy V, Manning KB, Welz JP, Fontaine AA, Deutsch S.Wavelet transforms in the analysis of mechanical heart valve cavitation. J Biomech Eng. 2006 Apr;128(2):217-22.
2005
Deutsch S, Tarbell JM, Manning KB, Rosenberg G, Fontaine AA. Experimental Fluid Mechanics of Pulsatile Artificial Blood Pumps. Ann Rev Fluid Mech2006; 38:65-86. pdf
Long JA, Undar A, Manning KB, Deutsch S. Viscoelasticity of Pediatric Blood and its Implications for the Testing of a Pulsatile Pediatric Blood Pump. ASAIO J 2005; 51(5):563-566. pdf
Herbertson LH, Manning KB, Reddy V, Fontaine AA, Tarbell JM, Deutsch S. The effect of dissolved carbon dioxide on cavitation intensity in mechanical heart valves. J Heart Valve Dis. 2005 Nov;14(6):835-42.
Sohn K, Manning KB, Fontaine AA, Tarbell JM, and Deutsch S. Acoustic and visual characteristics of cavitation induced by mechanical heart valves. J Heart Valve Dis 2005;14:551-558. pdf
Oley LA, Manning KB, Fontaine AA, Deutsch S. Off design considerations of the 50cc Penn State ventricular assist device. Artif Organs 2005;29:378-386. pdf
Manning KB, Przybysz TM, Fontaine AA, Tarbell JM, and Deutsch S. Near field flow characteristics of the Bjork-Shiley Monostrut valve in a modified single shot valve chamber. ASAIO J2005;51:133-138. pdf
2004
Hochareon P, Manning KB, Fontaine AA, Tarbell JM, and Deutsch S. Correlation of in vivo clot deposition with the flow characteristics in the 50cc Penn State Artificial Heart: a preliminary study. ASAIO J 2004;50:537-542. pdf
Hochareon P, Manning KB, Fontaine AA, Tarbell JM, and Deutsch S. Wall shear-rate estimation within the 50cc Penn State Artificial Heart using particle image velocimetry. ASME J Biomech Eng 2004;126:430-437. pdf
Hochareon P, Manning KB, Fontaine AA, Tarbell JM, and Deutsch S. Fluid dynamic analysis of the 50cc Penn State Artificial Heart under physiological operating conditions using particle image velocimetry. ASME J Biomech Eng. 2004; 126:585-593. pdf
2003
Manning KB, Kini V, Fontaine AA, Deutsch S, and Tarbell JM. Regurgitant flow field characteristics of the St. Jude Bileaflet mechanical heart valve under physiologic pulsatile flow using particle image velocimetry. Artif Organs 2003;27:840-846. pdf
Hochareon P, Manning KB, Fontaine AA, Deutsch S, and Tarbell JM. Diaphragm motion affects flow patterns in an artificial heart. Artif Organs2003;27:1102-1109. pdf
Johansen P, Manning KB, Tarbell JM, Fontaine AA, Deutsch S, and Nygaard H. A new method for evaluation of cavitation near mechanical heart valves. ASME J Biomech Eng 2003;125:663-670. pdf