On 2/28/18, Seoyoung defended her thesis entitled: “The Role of the Membrane in Integrin-Mediated Adhesion of Cells to Surfaces.” This work highlighted how lipids can influence mechanical interaction of cells with their surroundings much like they influence chemical interactions. Seoyoung also developed a new method to measure, for the first time, mechanical properties of cell membranes in their native state. Nice work Seoyoung!
Xi Zhao led a team of researchers from multiple universities to uncover how impulsive enzymes can migrate up substrate concentration gradients and coalesce into signaling complexes. The article, entitled, “Substrate-driven chemotactic assembly in an enzyme cascade,” appears in Nature Chemistry: https://www.nature.com/articles/nchem.2905 . Congratulations Xi!
Seoyoung Son and Pouria Fattahi will present their work at the 2017 BMES fall meeting in Phoenix from 10/11 – 10/14.
Here are some links to their presentations:
Thursday, October 12, 2017
9:30 AM – 5:00 PM Exhibit Hall 300 North
|P-TH-182A new in situ method to measure area-per-lipid fluctuations in cell membranes using time –resolved fluorescence of DiI S. Son, H. Muddana, P. Butler.|
Drug Delivery & Intelligent Systems
Friday, October 13, 2017
3:30 PM – 5:00 PM Room 221C
|4:15 PM – 4:30 PM||The Role of Cellular Morphology in Nanoparticle Uptake P. FATTAHI, Y. Yeh, S. Zheng, S. Zhang, J. Brown, P. Butler.|
Seoyoung Son recently showed that the lipid bilayer influences all aspects of adhesion to the extracellular matrix, at the single integrin molecule level, all the way to cell migration. The work is described in a new article in Biophysical Journal. Congratulations Seoyoung!
Pouria Fattahi recently defended his dissertation. His work on mechanotargeting of nanoparticles to endothelial cells changes our thinking of nanoscale drug delivery. Congratulations Pouria!