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Welcome to the Lindner Laboratory at Penn State in the Department of Biochemistry & Molecular Biology. Simply stated: our work couples molecular parasitology and structural biology to understand the malaria parasite (Plasmodium spp.), so that we can identify and exploit weaknesses in the parasite’s development and transmission.









Lindner Lab (September 2017)

Front Row (Left-to-Right): Kelly Rios, Trace Besemer, Kevin Hart
Back Row (Left-to-Right): Allen Minns, Steve Griffin, Scott Lindner, Mike Walker
Not Pictured: Tyler Earp, Logan Finger, Liv Smith


Latest News for the Lindner Lab (Get the full version at the Lindner Lab News Page)

A collaborative project with Noah Butler (U. Iowa) and Marion Pepper (U. Washington) on cGAS-mediated control of Plasmodium blood stage infections is now out in JCI Insight. (20180125)

Kelly Rios has passed her Candidacy Exam and is now a Ph.D. Candidate in our BMMB Program. Congrats, Kelly! (20180112)

Allen Minns has published on PABP1 and PABP2 in Plasmodium yoelii in mSphere! This is work done also by Kevin Hart and in collaboration with Susan Hafenstein‘s lab. Congrats, Allen! (20180110)

Liv Smith has joined our research group as an undergraduate researcher, focusing on proximity-based biotinylation approaches for proteomics. Welcome, Liv! (20180108)

I (Scott) received a Notice of Award from NIGMS for our 2nd R01: a Multi-PI R01 with Susan Hafenstein (and Phil Bevilacqua as co-investigator)! This will fund our Cryo-EM efforts for the next 4 years to push the boundaries of what is possible for structural studies of Plasmodium proteins (big or small!). (20171230)

A collaborative project with Noah Butler (U. Iowa) on B-cell and T-cell effects during Plasmodium infection is now out in Cell Reports. (20171114)

Kelly Rios was chosen for giving one of the best Poster Presentations of the MPM meeting. Congrats, Kelly! (20170914)

Mike Walker was chosen for giving one of the best Turbo Talks of the MPM meeting. Congrats, Mike! (20170914)

Kevin Hart and Mike Walker gave great talks at the Molecular Parasitology Meeting (MPM) at Woods Hole, MA! (20170914)

Logan Finger has joined our research group as an undergraduate researcher, focusing on stage-specific gene expression and promoter cis elements. Welcome, Logan! (20180821)

Our work on ALBA4 is now out in Molecular Microbiology, which is the first report of comparative RNA-seq and comparative targeted proteomics in Plasmodium in asexual blood stages, sexual stages, and even sporozoites! (20170808)

Mike Walker has received a Huck Graduate Research Innovation (GRI) grant! This work will help support his efforts to use CRISPR in the malaria parasite. Congrats, Mike! (20170615)

I (Scott) just got word that TWO R21’s that we are a part of will be funded! The first is our solo proposal for CRISPR’ing Plasmodium, the second (subcontract with KK Ojo, U. Washington) is for developing combination drug partners for Plasmodium. Needless to say… WE’RE HIRING!! (20170605)

Erin Vrana gave an incredible Poster Talk at the American Society for Microbiology annual meeting (ASM Microbe) in New Orleans, LA. See a photo here. (20170602)

Tyler Earp has joined the Lindner Lab as a Research Technologist 1 to support our mosquito rearing and mouse experiments, with his own project soon to be determined. Welcome, Tyler! (20170530)

I (Scott) was profiled in the new MicroNow site from American Society for Microbiology (ASM) for my talk on our work on CRISPR in Plasmodium. (20170526)

Our paper in PLOS Pathogens was one of the Top 50 most cited in 2016! This describes the surface proteomics and glycomics of Plasmodium sporozoites. (20170525)

Amanda Reese, Erin Vrana, and Laura Bowman graduated with their BS degrees this past weekend! We’ve been so fortunate to work with you. Best luck in the next chapters at Vandy, Austria, and South America! (20170508)

Erin Vrana has been awarded 1st Place for her presentation at the Penn State Undergraduate Research Expo out of hundred of students! What an accomplishment! Erin’s poster will be displayed in Old Main for the rest of the semester, and will receive a plaque and some cold hard cash. What a tremendous honor, Erin! (20170407)

Erin Vrana‘s abstract for the ASM Microbe Meeting was selected as an Outstanding Student Abstract Award! Erin will present her work on an essential RNA-binding protein in NOLA this June. Congrats, Erin! (20170329)



<See Lindner Lab News for More!>



The Lindner Laboratory is housed in the Millennium Science Complex, which brings together a variety of top-notch research groups to build an interdisciplinary, collaborative environment.



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