Recent Publications The Endoplasmic Reticulum Stress Sensor IRE1α Regulates the UV DNA Repair Response through the Control of Intracellular Calcium Homeostasis. Son J., Mogre S., Chalmers FE., Ibinson J,. Worrell S., Glick AB. J Invest Dermatol. 2021 Re-engineering Antimicrobial Peptides into Oncolytics Targeting Drug-Resistant Ovarian Cancers. Aronson MR, Dahl ES., Halle JA., Simonson AW., Gogal RA., Glick AB., Aird KM., Medina SH. Cell Mol Bioeng. 13:447-461, 2020. Photocontrolled miR-148b nanoparticles cause apoptosis, inflammation and regression of Ras induced epidermal squamous cell carcinomas in mice. Liu Y, Bailey JT, Abu-Laban M, Li S, Chen C, Glick AB, Hayes DJ. Biomaterials. 256:120212, 2020. Ultrasound-Guided Cytosolic Protein Delivery via Transient Fluorous Masks. Sloand JN, Nguyen TT, Zinck SA, Cook EC, Zimudzi TJ, Showalter SA, Glick AB, Simon JC, Medina SH. ACS Nano. 14:4061-4073, 2020. The multiple roles of the unfolded protein response regulator IRE1α in cancer. Chalmers F, Mogre S, Son J, Blazanin N, Glick AB. Mol Carcinog. 58:1623-1630, 2019. Editors Highlight: Ah Receptor Activation Potentiates Neutrophil Chemoattractant (C-X-C Motif) Ligand 5 Expression in Keratinocytes and Skin. Smith KJ, Boyer JA., Muku GE., Murray IA., Gowda, K., Desai, D., Amin, SG, Glick, AB., Perdew, GH. Toxicol Sci 160: 83-94, 2017. ER stress and distinct outputs of the IRE1α RNase control proliferation and senescence in response to oncogenic Ras. Blazanin N, Son J, Craig-Lucas AB, John CL, Breech KJ, Podolsky MA, Glick AB. Proc Natl Acad Sci U S A. 114: 9900-9905, 2017. Differentiated State of Initiating Tumor Cells Is Key to Distinctive Immune Responses Seen in H-RasG12V-Induced Squamous Tumors. Podolsky MA, Bailey JT, Gunderson AJ, Oakes CJ, Breech K, Glick AB. Cancer Immunol Res. 5:198-210, 2017. Ah receptor activation potentiates neutrophil chemoattractant (C-X-C motif) ligand 5 expression in keratinocytes and skin. Smith KJ, Boyer JA, Muku GE, Murray IA, Gowda K, Desai D, Amin SG, Glick AB, Perdew GH. Toxicol Sci. 2017 Estrogen modulates mesenchyme-epidermis interactions in the adult nipple.Wu HJ, Oh JW, Spandau DF, Tholpady S, Diaz J 3rd, Schroeder LJ, Offutt CD, Glick AB, Plikus MV, Koyama S, Foley J. Development. 144:1498-1509, 2017 Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation.van den Bogaard EH, Podolsky MA, Smits JP, Cui X, John C, Gowda K, Desai D, Amin SG, Schalkwijk J, Perdew GH, Glick AB.J Invest Dermatol.135:1320-1328, 2015. The nuclear receptor peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress.Zhu B, Ferry CH, Markell LK, Blazanin N, Glick AB, Gonzalez FJ, Peters JM. J Biol Chem. 289:20102-19, 2014. Tumor-promoting role of TGFβ1 signaling in ultraviolet B-induced skin carcinogenesis is associated with cutaneous inflammation and lymph node migration of dermal dendritic cells. Ravindran A, Mohammed J, Gunderson AJ, Cui X, Glick AB. Carcinogenesis. 35:959-66, 2014. CD8(+) T cells mediate RAS-induced psoriasis-like skin inflammation through IFN-γ. Gunderson AJ, Mohammed J, Horvath FJ, Podolsky MA, Anderson CR, Glick AB. J Invest Dermatol. 133:955-63, 2013. TGFβ1 overexpression by keratinocytes alters skin dendritic cell homeostasis and enhances contact hypersensitivity. Mohammed J, Gunderson AJ, Khong HH, Koubek RD, Udey MC, Glick AB. J Invest Dermatol. 133:135-43, 2013.