Publications

Reverse metabolomics for the discovery of chemical structures from humans EC Gentry, SL Collins, M Panitchpakdi, P Belda-Ferre, AK Stewart, … Nature, 1-3		2023
Human Intestinal Microbiome Determines Individualized Inflammatory Response to Dietary Emulsifier Carboxymethylcellulose Consumption N Daniel, GD Wu, W Walters, C Compher, J Ni, C Delaroque, L Albenberg, … Cellular and Molecular Gastroenterology and Hepatology		2023
Changes in the Type 2 diabetes gut mycobiome associate with metformin treatment across populations E Van Syoc, MP Nixon, JD Silverman, Y Luo, FJ Gonzalez, I Elbere, … bioRxiv: the preprint server for biology		2023
Refined fiber inulin promotes inflammation‐associated colon tumorigenesis by modulating microbial succinate production S Tian, D Paudel, F Hao, R Neupane, R Castro, AD Patterson, AK Tiwari, … Cancer Reports 6 (11), e1863		2023
Changes in fecal lipidome after treatment with ivacaftor without changes in microbiome or bile acids R Bass, C Tanes, K Bittinger, Y Li, H Lee, ES Friedman, I Koo, … Journal of Cystic Fibrosis		2023
Induction of AHR Signaling in Response to the Indolimine Class of Microbial Stress Metabolites D Patel, IA Murray, F Dong, AJ Annalora, K Gowda, DM Coslo, … Metabolites 13 (9), 985		2023
Accumulation of Linoleic Acid by Altered Peroxisome Proliferator-Activated Receptor-α Signaling Is Associated with Age-Dependent Hepatocarcinogenesis in Ppara Transgenic Mice X Zhu, Q Liu, AD Patterson, AK Sharma, SG Amin, SM Cohen, … Metabolites 13 (8), 936		2023
A Taxonomically-informed Mass Spectrometry Search Tool for Microbial Metabolomics Data P Dorrestein, S Zuffa, R Schmid, A Bauermeister, PWP Gomes, …		2023
A Taxonomically-informed Mass Spectrometry Search Tool for Microbial Metabolomics Data S Zuffa, R Schmid, A Bauermeister, PWP Gomes, … Research Square		2023
Endogenous Tryptophan-Derived Ah Receptor Ligands are Dissociated from CYP1A1/1B1-Dependent Negative-Feedback F Dong, AJ Annalora, IA Murray, Y Tian, CB Marcus, AD Patterson, … International Journal of Tryptophan Research 16, 11786469231182508		2023
Molecular networking identifies an AHR-modulating benzothiazole from white button mushrooms (Agaricus bisporus) X Chen, AD Patterson, GH Perdew, IA Murray, JJ Kellogg Journal of Functional Foods 106, 105602		2023
Profiling the human intestinal environment under physiological conditions D Shalon, RN Culver, JA Grembi, J Folz, PV Treit, H Shi, FA Rosenberger, … Nature, 1-11		2023
Mo1711 FERMENTABLE DIETARY FIBER-INDUCED SHIFT IN GUT MICROBIOTA METABOLIC ACTIVITY EXACERBATES COLITIS-ASSOCIATED COLON TUMORIGENESIS S Tian, D Paudel, F Hao, R Neupane, R Castro, AD Patterson, AK Tiwari, … Gastroenterology 164 (6), S-875		2023
Early-life exposure to a potent Aryl hydrocarbon receptor ligand results in persistent changes to the microbiota and host glucose homeostasis Y Tian, B Rimal, JE Bisanz, W Gui, TM Wolfe, I Koo, IM Murray, …		2023
Bile acids and the gut microbiota: Metabolic interactions and impacts on disease SL Collins, JG Stine, JE Bisanz, CD Okafor, AD Patterson Nature Reviews Microbiology 21 (4), 236-247		2023
The Ah Receptor from Toxicity to Therapeutics: Report from the 5th AHR Meeting at Penn State University, USA, June 2022 GH Perdew, C Esser, M Snyder, DH Sherr, EH van den Bogaard, … International journal of molecular sciences 24 (6), 5550		2023
Aryl hydrocarbon receptor activation affects nitrergic neuronal survival and delays intestinal motility in mice A Vijay, NR Boyle, SM Kumar, GH Perdew, S Srinivasan, AD Patterson Toxicological Sciences 192 (1), 117-128		2023
Complex chemical signals dictate Ah receptor activation through the gut-lung axis F Dong, IA Murray, A Annalora, D Coslo, D Desai, K Gowda, J Yang, … bioRxiv, 2023.02. 22.529529		2023
Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer L Sun, Y Zhang, J Cai, B Rimal, ER Rocha, JP Coleman, C Zhang, … Nature communications 14 (1), 755		2023
Aryl hydrocarbon receptor activation coordinates mouse small intestinal epithelial cell programming X Zhou, D Chakraborty, IA Murray, D Coslo, Z Kehs, A Vijay, C Ton, … Laboratory Investigation 103 (2), 100012		2023
Loss of selenoprotein W in murine macrophages alters the hierarchy of selenoprotein expression, redox tone, and mitochondrial functions during inflammation S Misra, TJ Lee, A Sebastian, J McGuigan, C Liao, I Koo, AD Patterson, … Redox Biology 59, 102571		2023
Growth Hormone Alters Circulating Levels of Glycine and Hydroxyproline in Mice JA Young, S Duran-Ortiz, S Bell, K Funk, Y Tian, Q Liu, AD Patterson, … Metabolites 13 (2), 191		2023
Contribution of circulating host and microbial tryptophan metabolites towards Ah receptor activation EW Morgan, F Dong, A Annalora, IA Murray, T Wolfe, R Erickson, … bioRxiv, 2023.01. 26.525691		2023
Method for the diagnosis and prognosis of cancer M Haznadar, E Mathe, AD Patterson, CC Harris, F Gonzalez, K Krausz, … US Patent 11,555,818		2023
A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity M Alexander, V Upadhyay, R Rock, L Ramirez, P Puchalska, D Orellana, … bioRxiv, 2023.11. 02.565382		2023
Comparative urine metabolomics of mice treated with non-toxic and toxic oral doses of (−)-epigallocatechin-3-gallate S Hwang, I Koo, AD Patterson, JD Lambert Food & Function 14 (20), 9434-9445		2023
Urine-based Detection of Congenital Portosystemic Shunt in C57BL/6 Mice BS Yeoh, RM Golonka, P Saha, MR Kandalgaonkar, Y Tian, I Osman, … Function 4 (5), zqad040		2023
Changes in the gut mycobiome are associated with Type 2 diabetes mellitus and metformin treatment across populations E Van Syoc, MP Nixon, JD Silverman, Y Luo, FJ Gonzalez, I Elbere, … bioRxiv, 2023.05. 25.542255		2023
Itaconate promotes the differentiation of murine stress erythroid progenitors by increasing Nrf2 activity. B Ruan, Y Chen, SG Trimidal, I Koo, J Cai, J Mcguigan, M Hall, … bioRxiv, 2023.03. 11.532211		2023
Nitric oxide regulates metabolism in murine stress erythroid progenitors to promote recovery during inflammatory anemia. B Ruan, SG Trimidal, I Koo, F Qian, J Cai, J Mcguigan, M Hall, … bioRxiv, 2023.03. 11.532207		2023
Psyllium fiber protects against colitis via activation of bile acid sensor farnesoid X receptor A Bretin, J Zou, B San Yeoh, VL Ngo, S Winer, DA Winer, L Reddivari, … Cellular and Molecular Gastroenterology and Hepatology 15 (6), 1421-1442		2023
Diet standardization reduces intra-individual microbiome variation C Delaroque, GD Wu, C Compher, J Ni, L Albenberg, Q Liu, Y Tian, … Gut microbes 14 (1), 2149047		2022
A microbiome-dependent gut–brain pathway regulates motivation for exercise L Dohnalová, P Lundgren, JRE Carty, N Goldstein, SL Wenski, … Nature 612 (7941), 739-747		2022
Genetic differences in nicotine sensitivity and metabolism in C57BL/6J and NOD/ShiLtJ mouse strains LR Seemiller, LR Goldberg, PB Smith, J Dennis, AD Patterson, TJ Gould Neuropharmacology 221, 109279		2022
Glycine‐β‐muricholic acid antagonizes the intestinal farnesoid X receptor–ceramide axis and ameliorates NASH in mice J Jiang, Y Ma, Y Liu, D Lu, X Gao, KW Krausz, D Desai, SG Amin, … Hepatology Communications 6 (12), 3363-3378		2022
The unfolded protein response gene Ire1α is required for tissue renewal and normal differentiation in the mouse tongue and esophagus FE Chalmers, S Mogre, B Rimal, J Son, AD Patterson, DB Stairs, AB Glick Developmental biology 492, 59-70		2022
Interaction of sodium acetate supplementation and dietary fiber level on feeding behavior, digestibility, milk synthesis, and plasma metabolites C Matamoros, F Hao, Y Tian, AD Patterson, KJ Harvatine Journal of dairy science 105 (11), 8824-8838		2022
Bile Acids Are Substrates for Amine N-Acyl Transferase Activity by Bile Salt Hydrolase A Patterson, B Rimal, S Collins, M Granda, I Koo, S Solanka, N Hoque, …		2022
AHR is a master regulator of diverse pathways in endogenous metabolism JC Granados, K Falah, I Koo, EW Morgan, GH Perdew, AD Patterson, … Scientific reports 12 (1), 16625		2022
Bile acid conjugation deficiency causes hypercholanemia, hyperphagia, islet dysfunction, and gut dysbiosis in mice BD Alrehaili, M Lee, S Takahashi, R Novak, B Rimal, S Boehme, … Hepatology Communications 6 (10), 2765-2780		2022
Early life polychlorinated biphenyl 126 exposure disrupts gut microbiota and metabolic homeostasis in mice fed with high-fat diet in adulthood Y Tian, B Rimal, W Gui, I Koo, PB Smith, S Yokoyama, AD Patterson Metabolites 12 (10), 894		2022
Effects of Short Chain Fatty Acid Supplementation in Modulation of Gut Microbiome and T-Regulatory Cells in Health and New Onset Rheumatoid Arthritis R Blank, A Boix-Amoros, R Nayak, AJ Hernandez, S Catron, Z Uddin, … ARTHRITIS & RHEUMATOLOGY 74, 3935-3936		2022
Effect of 2-hydroxy-4-(methylthio) butanoate (HMTBa) on milk fat, rumen environment and biohydrogenation, and rumen protozoa in lactating cows fed diets with increased risk for … M Baldin, D Garcia, GI Zanton, F Hao, AD Patterson, KJ Harvatine Journal of dairy science 105 (9), 7446-7461		2022
Early Life Short-Term Exposure to Polychlorinated Biphenyl 126 in Mice Leads to Metabolic Dysfunction and Microbiota Changes in Adulthood Y Tian, B Rimal, W Gui, I Koo, S Yokoyama, GH Perdew, AD Patterson International journal of molecular sciences 23 (15), 8220		2022
Bile acid metabolism and signaling, the microbiota, and metabolic disease J Cai, B Rimal, C Jiang, JYL Chiang, AD Patterson Pharmacology & Therapeutics, 108238		2022
Multi-omics strategies for investigating the microbiome in toxicology research EW Morgan, GH Perdew, AD Patterson Toxicological Sciences 187 (2), 189-213		2022
Randomized controlled-feeding study of dietary emulsifier carboxymethylcellulose reveals detrimental impacts on the gut microbiota and metabolome B Chassaing, C Compher, B Bonhomme, Q Liu, Y Tian, W Walters, … Gastroenterology 162 (3), 743-756		2022
Defective humoral immunity disrupts bile acid homeostasis which promotes inflammatory disease of the small bowel AD Mohammed, Z Mohammed, MM Roland, I Chatzistamou, A Jolly, … Nature communications 13 (1), 525		2022
Profiling of the human intestinal microbiome and bile acids under physiologic conditions using an ingestible sampling device D Shalon, RN Culver, JA Grembi, J Folz, P Treit, L Dethlefsen, X Meng, … bioRxiv, 2022.01. 19.476920		2022
The role of mouse and human peroxisome proliferator-activated receptor-α in modulating the hepatic effects of perfluorooctane sulfonate in mice S Su, LJ Billy, S Chang, FJ Gonzalez, AD Patterson, JM Peters Toxicology 465, 153056		2022
Metabolomic profiling of stool of two‐year old children from the INSIGHT study reveals links between butyrate and child weight outcomes D Nandy, SJC Craig, J Cai, Y Tian, IM Paul, JS Savage, ME Marini, … Pediatric obesity 17 (1), e12833		2022
Reconstitution of the host holobiont in germ-free born male rats acutely increases bone growth and affects marrow cellular content PJ Czernik, RM Golonka, S Chakraborty, BS Yeoh, AA Abokor, P Saha, … Physiological genomics 53 (12), 518-533		2021
The East Asian gut microbiome is distinct from colocalized White subjects and connected to metabolic health QY Ang, DL Alba, V Upadhyay, JE Bisanz, J Cai, HL Lee, E Barajas, … Elife 10, e70349		2021
A centenarian entourage of bile acids and gut bacteria B Rimal, AD Patterson NATURE		2021
A Synthesis-Based Reverse Metabolomics Approach for the Discovery of Chemical Structures from Humans and Animals. P Dorrestein, E Gentry, S Collins, M Panitchpakdi, P Belda-Ferre, …		2021
Exercise training reverses gut dysbiosis in patients with biopsy-proven nonalcoholic steatohepatitis: a proof of concept study A Hughes, J Dahmus, G Rivas, B Hummer, JRC See, JR Wright, … Clinical Gastroenterology and Hepatology 19 (8), 1723-1725		2021
Current Challenges and Recent Developments in Mass Spectrometry–Based Metabolomics SL Collins, I Koo, JM Peters, PB Smith, AD Patterson Annual review of analytical chemistry 14, 467-487		2021
Caloric restriction disrupts the microbiota and colonization resistance RJ von Schwartzenberg, JE Bisanz, S Lyalina, P Spanogiannopoulos, … Nature 595 (7866), 272-277		2021
Comparison of the effects of short-term feeding of sodium acetate and sodium bicarbonate on milk fat production C Matamoros, J Cai, AD Patterson, KJ Harvatine Journal of dairy science 104 (7), 7572-7582		2021
The aryl hydrocarbon receptor activates ceramide biosynthesis in mice contributing to hepatic lipogenesis Q Liu, L Zhang, EL Allman, TD Hubbard, IA Murray, F Hao, Y Tian, W Gui, … Toxicology 458, 152831		2021
The pretreatment gut microbiome is associated with lack of response to methotrexate in new‐onset rheumatoid arthritis A Artacho, S Isaac, R Nayak, A Flor‐Duro, M Alexander, I Koo, … Arthritis & rheumatology 73 (6), 931-942		2021
Metabolomics reveal dynamic host responses in lipid, amino acid, and energy metabolism after acute exposure of gut microbiota in germ‐free rats R Golonka, S Chakraborty, B Mell, P Saha, A Abokor, JY Yeo, X Cheng, … The FASEB Journal 35		2021
Methotrexate impacts conserved pathways in diverse human gut bacteria leading to decreased host immune activation RR Nayak, M Alexander, I Deshpande, K Stapleton-Gray, B Rimal, … Cell host & microbe 29 (3), 362-377. e11		2021
Impaired intestinal Akkermansia muciniphila and aryl hydrocarbon receptor ligands contribute to nonalcoholic fatty liver disease in mice Z Shi, H Lei, G Chen, P Yuan, Z Cao, HL Ser, X Zhu, F Wu, C Liu, M Dong, … Msystems 6 (1), 10.1128/msystems. 00985-20		2021
Secondary bile acid ursodeoxycholic acid alters weight, the gut microbiota, and the bile acid pool in conventional mice JA Winston, A Rivera, J Cai, AD Patterson, CM Theriot PLoS One 16 (2), e0246161		2021
Roux-en-Y Gastric Bypass Surgery Has Early Differential Effects on Bile Acids and the Levels of Complement Component 3 and Acylation-Stimulating Protein OF Noel, X Chu, AD Patterson, MA Edwards, CD Still, GS Gerhard Obesity Surgery 31, 773-780		2021
Selenium-dependent metabolic reprogramming during inflammation and resolution AM Korwar, A Hossain, TJ Lee, AE Shay, V Basrur, K Conlon, PB Smith, … Journal of Biological Chemistry 296		2021
Quantitative analysis of bile acid with UHPLC-MS/MS Y Tian, J Cai, EL Allman, PB Smith, AD Patterson Translational Bioinformatics for Therapeutic Development, 291-300		2021
Sample preparation and data analysis for NMR-based metabolomics TK Mal, Y Tian, AD Patterson Translational Bioinformatics for Therapeutic Development, 301-313		2021
A thermogenic fat-epithelium cell axis regulates intestinal disease tolerance K Man, C Bowman, KN Braverman, V Escalante, Y Tian, JE Bisanz, … Proceedings of the National Academy of Sciences 117 (50), 32029-32037		2020
Metabolic impact of persistent organic pollutants on gut microbiota Y Tian, W Gui, B Rimal, I Koo, PB Smith, RG Nichols, J Cai, Q Liu, … Gut Microbes 12 (1), 1848209		2020
Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity F Dong, F Hao, IA Murray, PB Smith, I Koo, AM Tindall, PM Kris-Etherton, … Gut microbes 12 (1), 1788899		2020
IDENTIFICATION OF A PLASMA LIPIDOMIC PATTERN FOR THE DIAGNOSIS OF NON-ALCOHOLIC FATTY LIVER DISEASE Y Saiman, E Scorletti, H Zheng, N Mahmud, Q Liu, I Koo, C Lin, … HEPATOLOGY 72, 919A-920A		2020
Reconstitution of the Host Holobiont Acutely Increases Bone Growth of the Gnotobiotic Rat P Czernik, RM Golonka, S Chakraborty, BS Yeoh, S Piu, A Ahmed, B Mell, … JOURNAL OF BONE AND MINERAL RESEARCH 35, 278-278		2020
Differences in the gut microbiomes of distinct ethnicities within the same geographic area are linked to host metabolic health QY Ang, DL Alba, V Upadhyay, JE Bisanz, J Cai, HL Lee, E Barajas, … bioRxiv, 2020.10. 23.352807		2020
How gut microbiome interactions affect nutritional traits of Drosophila melanogaster JG McMullen, G Peters-Schulze, J Cai, AD Patterson, AE Douglas Journal of Experimental Biology 223 (19), jeb227843		2020
Impact of facultative bacteria on the metabolic function of an obligate insect-bacterial symbiosis F Blow, NYD Ankrah, N Clark, I Koo, EL Allman, Q Liu, M Anitha, … Mbio 11 (4), 10.1128/mbio. 00402-20		2020
Metabolic Profiling Reveals Aggravated Non-Alcoholic Steatohepatitis in High-Fat High-Cholesterol Diet-Fed Apolipoprotein E-Deficient Mice Lacking Ron Receptor Signaling JN Allen, A Dey, J Cai, J Zhang, Y Tian, M Kennett, Y Ma, TJ Liang, … Metabolites 10 (8), 326		2020
MDM2-dependent rewiring of metabolomic and lipidomic profiles in dedifferentiated liposarcoma models A Patt, B Demoret, C Stets, KL Bill, P Smith, A Vijay, A Patterson, J Hays, … Cancers 12 (8), 2157		2020
Lipocalin 2 deficiency-induced gut microbiota dysbiosis evokes metabolic syndrome in aged mice V Singh, S Galla, RM Golonka, AD Patterson, B Chassaing, B Joe, … Physiological genomics 52 (8), 314-321		2020
Vancomycin prevents fermentable fiber-induced liver cancer in mice with dysbiotic gut microbiota V Singh, BS Yeoh, AA Abokor, RM Golonka, Y Tian, AD Patterson, B Joe, … Gut Microbes 11 (4), 1077-1091		2020
The microbiome modulating activity of bile acids Y Tian, W Gui, I Koo, PB Smith, EL Allman, RG Nichols, B Rimal, J Cai, … Gut microbes 11 (4), 979-996		2020
Ketogenic diets alter the gut microbiome resulting in decreased intestinal Th17 cells QY Ang, M Alexander, JC Newman, Y Tian, J Cai, V Upadhyay, … Cell 181 (6), 1263-1275. e16		2020
Bacterial colonization reprograms the neonatal gut metabolome K Bittinger, C Zhao, Y Li, E Ford, ES Friedman, J Ni, CV Kulkarni, J Cai, … Nature microbiology 5 (6), 838-847		2020
Nonalcoholic steatohepatitis Fitness Intervention in Thrombosis (NASHFit): Study protocol for a randomized controlled trial of a supervised aerobic exercise program to reduce … JG Stine, I Schreibman, S Navabi, M Kang, J Dahmus, C Soriano, G Rivas, … Contemporary Clinical Trials Communications 18, 100560		2020
Ursodeoxycholic acid (UDCA) mitigates the host inflammatory response during Clostridioides difficile infection by altering gut bile acids JA Winston, AJ Rivera, J Cai, R Thanissery, SA Montgomery, … Infection and Immunity 88 (6), 10.1128/iai. 00045-20		2020
Perfluorooctane sulfonate alters gut microbiota-host metabolic homeostasis in mice L Zhang, B Rimal, RG Nichols, Y Tian, PB Smith, E Hatzakis, SC Chang, … Toxicology 431, 152365		2020
Microbial metabolite signaling is required for systemic iron homeostasis NK Das, AJ Schwartz, G Barthel, N Inohara, Q Liu, A Sankar, DR Hill, … Cell metabolism 31 (1), 115-130. e6		2020
The gut microbiome: an orchestrator of xenobiotic metabolism SL Collins, AD Patterson Acta Pharmaceutica Sinica B 10 (1), 19-32		2020
Metatranscriptomic analysis of the mouse gut microbiome response to the persistent organic pollutant 2, 3, 7, 8-tetrachlorodibenzofuran RG Nichols, J Zhang, J Cai, IA Murray, I Koo, PB Smith, GH Perdew, … Metabolites 10 (1), 1		2019
Interplay between the host, the human microbiome, and drug metabolism RG Nichols, JM Peters, AD Patterson Human genomics 13 (1), 1-10		2019
The glycine conjugate of beta-muricholic acid as an inhibitor of the farnesoid x receptor for the treatment of obesity, insulin resistance or non-alcoholic fatty liver disease FJ Gonzalez, C Jiang, XIE Cen, AD PATTERSON, F Li, JB Mitchell, …		2019
Unraveling the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) expression in colon carcinogenesis JM Peters, V Walter, AD Patterson, FJ Gonzalez NPJ Precision Oncology 3 (1), 26		2019
The pre-treatment gut microbiome predicts early response to methotrexate in Rheumatoid Arthritis S Isaac, A Artacho, R Nayak, SB Abramson, M Alexander, I Koo, … ARTHRITIS & RHEUMATOLOGY 71		2019
The human transient receptor potential melastatin 2 ion channel modulates ROS through Nrf2 L Bao, F Festa, CS Freet, JP Lee, IM Hirschler-Laszkiewicz, S Chen, … Scientific reports 9 (1), 14132		2019
Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation V Singh, B San Yeoh, RE Walker, X Xiao, P Saha, RM Golonka, J Cai, … Gut 68 (10), 1801-1812		2019
Specialist and Generalist Fungal Parasites Induce Distinct Biochemical Changes in the Mandible Muscles of Their Host S Zheng, R Loreto, P Smith, A Patterson, D Hughes, L Wang International journal of molecular sciences 20 (18), 4589		2019
Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome (vol 25, pg 1225, 2019) X Qi, C Yun, L Sun, J Xia, Q Wu, Y Wang, L Wang, Y Zhang, X Liang, … Nature Medicine 25 (9), 1459-1459		2019
Publisher Correction: Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome X Qi, C Yun, L Sun, J Xia, Q Wu, Y Wang, L Wang Nature Medicine 25 (9), 1459-1460		2019
Method for the diagnosis and prognosis of cancer M Haznadar, E Mathe, AD Patterson, CC Harris, F Gonzalez, K Krausz, … US Patent 10,393,745		2019
Nutrient sensing in CD11c cells alters the gut microbiota to regulate food intake and body mass DN Chagwedera, QY Ang, JE Bisanz, YA Leong, K Ganeshan, J Cai, … Cell metabolism 30 (2), 364-373. e7		2019
Gender differences in phytoestrogens and the relationship with speed of processing in older adults: a cross-sectional analysis of NHANES, 1999–2002 J Alwerdt, AD Patterson, MJ Sliwinski Nutrients 11 (8), 1780		2019
Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome X Qi, C Yun, L Sun, J Xia, Q Wu, Y Wang, L Wang, Y Zhang, X Liang, … Nature medicine 25 (8), 1225-1233		2019
Vitamin D regulates the microbiota to control the numbers of RORγt/FoxP3+ regulatory T cells in the colon MT Cantorna, YD Lin, J Arora, S Bora, Y Tian, RG Nichols, AD Patterson Frontiers in immunology 10, 1772		2019
Isolation and Identification of Aryl Hydrocarbon Receptor Modulators in White Button Mushrooms (Agaricus bisporus) Y Tian, W Gui, PB Smith, I Koo, IA Murray, MT Cantorna, GH Perdew, … Journal of agricultural and food chemistry 67 (33), 9286-9294		2019
Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche S Hao, J Xiang, DC Wu, JW Fraser, B Ruan, J Cai, AD Patterson, ZC Lai, … Blood advances 3 (14), 2205-2217		2019
A review of analytical platforms for accurate bile acid measurement M Dutta, J Cai, W Gui, AD Patterson Analytical and bioanalytical chemistry 411, 4541-4549		2019
Evaluating the structural complexity of isomeric bile acids with ion mobility spectrometry X Zheng, FB Smith, NA Aly, J Cai, RD Smith, AD Patterson, ES Baker Analytical and bioanalytical chemistry 411, 4673-4682		2019
Secondary bile acid ursodeoxycholic acid (UDCA) alters weight, the gut microbiota, and the bile acid pool in conventional mice JA Winston, A Rivera, J Cai, AD Patterson, CM Theriot bioRxiv, 698795		2019
A Quantitative HILIC–MS/MS Assay of the Metabolic Response of Huh-7 Cells Exposed to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Q Liu, J Cai, RG Nichols, Y Tian, J Zhang, PB Smith, Y Wang, C Yan, … Metabolites 9 (6), 118		2019
Inhibitors of the farnesoid x receptor and uses in medicine FJ Gonzalez, C Jiang, C Xie, AD Patterson, F Li, JB Mitchell, S Amin, … US Patent 10,233,209		2019
Microbiota metabolism promotes synthesis of the human Ah receptor agonist 2, 8-dihydroxyquinoline TD Hubbard, Q Liu, IA Murray, F Dong, C Miller III, PB Smith, K Gowda, … Journal of proteome research 18 (4), 1715-1724		2019
Berberine directly affects the gut microbiota to promote intestinal farnesoid X receptor activation Y Tian, J Cai, W Gui, RG Nichols, I Koo, J Zhang, M Anitha, AD Patterson Drug Metabolism and Disposition 47 (2), 86-93		2019
Retinoic acid mediated clearance of Citrobacter rodentium in vitamin A deficient mice requires CD11b+ and T cells LM Snyder, KL McDaniel, Y Tian, CH Wei, MJ Kennett, AD Patterson, … Frontiers in immunology 9, 3090		2019
Multiplatform physiologic and metabolic phenotyping reveals microbial toxicity J Cai, RG Nichols, I Koo, ZA Kalikow, L Zhang, Y Tian, J Zhang, PB Smith, … Msystems 3 (6), 10.1128/msystems. 00123-18		2018
Gut microbiota and intestinal FXR mediate the clinical benefits of metformin L Sun, C Xie, G Wang, Y Wu, Q Wu, X Wang, J Liu, Y Deng, J Xia, B Chen, … Nature medicine 24 (12), 1919-1929		2018
COGNITIVE OUTCOMES ASSOCIATED WITH PHENYLALANINE, AN ESSENTIAL AMINO ACID, IN A MIDDLE-AGED SAMPLE J Alwerdt, M Sliwinski, A Patterson Innovation in Aging 2 (Suppl 1), 879		2018
Structural and functional analysis of the gut microbiome for toxicologists RG Nichols, J Cai, IA Murray, I Koo, PB Smith, GH Perdew, AD Patterson Current protocols in toxicology 78 (1), e54		2018
Attenuation of Microbiotal Dysbiosis and Hypertension in a CRISPR/Cas9 Gene Ablation Rat Model of GPER1 H Waghulde, X Cheng, S Galla, B Mell, J Cai, SM Pruett-Miller, … Hypertension 72 (5), 1125-1132		2018
Metabolomic approaches reveal the role of CAR in energy metabolism F Chen, DM Coslo, T Chen, L Zhang, Y Tian, PB Smith, AD Patterson, … Journal of proteome research 18 (1), 239-251		2018
Dysregulated microbial fermentation of soluble fiber induces cholestatic liver cancer V Singh, B San Yeoh, B Chassaing, X Xiao, P Saha, RA Olvera, JD Lapek, … Cell 175 (3), 679-694. e22		2018
Lipid metabolism and lipophagy in cancer M Maan, JM Peters, M Dutta, AD Patterson Biochemical and biophysical research communications 504 (3), 582-589		2018
Molecular regulation of carcinogenesis: friend and foe AD Patterson, FJ Gonzalez, GH Perdew, JM Peters Toxicological Sciences 165 (2), 277-283		2018
The association of lipophilic phospholipids with native bovine casein micelles in skim milk: Effect of lactation stage and casein micelle size M Cheema, PB Smith, AD Patterson, A Hristov, FM Harte Journal of dairy science 101 (10), 8672-8687		2018
Intestine farnesoid X receptor agonist and the gut microbiota activate G‐protein bile acid receptor‐1 signaling to improve metabolism P Pathak, C Xie, RG Nichols, JM Ferrell, S Boehme, KW Krausz, … Hepatology 68 (4), 1574-1588		2018
Microbiome Metabolism and Chemical Transformation: How Does the Human Microbiome Change Our Chemical Exposures? A Patterson ISEE Conference Abstracts 2018 (1)		2018
Ron receptor signaling ameliorates hepatic fibrosis in a diet-induced nonalcoholic steatohepatitis mouse model J Allen, J Zhang, MD Quickel, M Kennett, AD Patterson, PA Hankey-Giblin Journal of proteome research 17 (9), 3268-3280		2018
Prebiotic effects of white button mushroom (Agaricus bisporus) feeding on succinate and intestinal gluconeogenesis in C57BL/6 mice Y Tian, RG Nichols, P Roy, W Gui, PB Smith, J Zhang, Y Lin, V Weaver, … Journal of Functional Foods 45, 223-232		2018
Regulation of vitamin D metabolism following disruption of the microbiota using broad spectrum antibiotics SA Bora, MJ Kennett, PB Smith, AD Patterson, MT Cantorna The Journal of nutritional biochemistry 56, 65-73		2018
Loss of MSP-dependent Ron receptor signaling exacerbates liver fibrosis in a high fat high cholesterol diet-induced ApoE KO mouse model JN Allen, M Kennett, A Patterson, PA Hankey-Giblin The Journal of Immunology 200 (1_Supplement), 42.26-42.26		2018
Vitamin A deficiency in mice alters host and gut microbial metabolism leading to altered energy homeostasis Y Tian, RG Nichols, J Cai, AD Patterson, MT Cantorna The Journal of nutritional biochemistry 54, 28-34		2018
Neuroprotective role of the ron receptor tyrosine kinase underlying central nervous system inflammation in health and disease A Dey, JN Allen, JW Fraser, LM Snyder, Y Tian, L Zhang, RF Paulson, … Frontiers in immunology 9, 513		2018
Metabolomics reveals aryl hydrocarbon receptor activation induces liver and mammary gland metabolic dysfunction in lactating mice KR Belton, Y Tian, L Zhang, M Anitha, PB Smith, GH Perdew, … Journal of proteome research 17 (4), 1375-1382		2018
The gut microbiota regulates endocrine vitamin D metabolism through fibroblast growth factor 23 SA Bora, MJ Kennett, PB Smith, AD Patterson, MT Cantorna Frontiers in immunology 9, 408		2018
Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis C Xie, T Yagai, Y Luo, X Liang, T Chen, Q Wang, D Sun, J Zhao, … Nature medicine 23 (11), 1298-1308		2017
Intermittent fasting promotes white adipose browning and decreases obesity by shaping the gut microbiota G Li, C Xie, S Lu, RG Nichols, Y Tian, L Li, D Patel, Y Ma, CN Brocker, … Cell metabolism 26 (4), 672-685. e4		2017
Dietary broccoli impacts microbial community structure and attenuates chemically induced colitis in mice in an Ah receptor dependent manner TD Hubbard, IA Murray, RG Nichols, K Cassel, M Podolsky, G Kuzu, … Journal of functional foods 37, 685-698		2017
Identification of a mouse Lactobacillus johnsonii strain with deconjugase activity against the FXR antagonist T-β-MCA M DiMarzio, B Rusconi, NH Yennawar, M Eppinger, AD Patterson, … PLoS one 12 (9), e0183564		2017
Orthogonal Comparison of GC–MS and ¹H NMR Spectroscopy for Short Chain Fatty Acid Quantitation J Cai, J Zhang, Y Tian, L Zhang, E Hatzakis, KW Krausz, PB Smith, … Analytical chemistry 89 (15), 7900-7906		2017
BissonWilliamEnvironMoleToxIntestineSelectiveFarnesoid. pdf C Jiang, C Xie, Y Lv, J Li, KW Krausz, S Jingmin, CN Brocker, D Desai, …		2017
GENDER DIFFERENCES IN PHYTOESTROGEN INTAKE AND SPEED OF PROCESSING PERFORMANCE IN OLDER ADULTS J Alwerdt, M Sliwinski, AD Patterson Innovation in Aging 1 (Suppl 1), 580		2017
Lipid emulsion added to a liquid high-carbohydrate diet and voluntary running exercise reduce lipogenesis and ameliorate early-stage hepatic steatosis in mice KH Huang, L Hao, PB Smith, CJ Rogers, AD Patterson, AC Ross The Journal of Nutrition 147 (5), 746-753		2017
Intestinal farnesoid X receptor signaling modulates metabolic disease FJ Gonzalez, C Jiang, C Xie, AD Patterson Digestive Diseases 35 (3), 178-184		2017
Modulation of urinary siderophores by the diet, gut microbiota and inflammation in mice X Xiao, B San Yeoh, P Saha, Y Tian, V Singh, AD Patterson, … The Journal of nutritional biochemistry 41, 25-33		2017
An intestinal farnesoid X receptor–ceramide signaling axis modulates hepatic gluconeogenesis in mice C Xie, C Jiang, J Shi, X Gao, D Sun, L Sun, T Wang, S Takahashi, … Diabetes 66 (3), 613-626		2017
The aryl hydrocarbon receptor as a moderator of host-microbiota communication L Zhang, RG Nichols, AD Patterson Current Opinion in Toxicology 2, 30-35		2017
Inhibitors of the farnesoid X receptor and uses in medicine FJ Gonzalez, C Jiang, C Xie, AD Patterson, F Li, JB Mitchell US Patent 9,540,415		2017
The role of toxic lipids metabolic disease FJ Gonzalez, C Xie, C Jiang, C Brocker, AD Patterson Drug Metabolism and Pharmacokinetics 1 (32), S11-S12		2017
Omics approaches to probe microbiota and drug metabolism interactions RG Nichols, NE Hume, PB Smith, JM Peters, AD Patterson Chemical research in toxicology 29 (12), 1987-1997		2016
Reversing methanogenesis to capture methane for liquid biofuel precursors VWC Soo, MJ McAnulty, A Tripathi, F Zhu, L Zhang, E Hatzakis, PB Smith, … Microbial cell factories 15, 1-14		2016
An intestinal microbiota–farnesoid X receptor axis modulates metabolic disease FJ Gonzalez, C Jiang, AD Patterson Gastroenterology 151 (5), 845-859		2016
Farnesoid X receptor signaling shapes the gut microbiota and controls hepatic lipid metabolism L Zhang, C Xie, RG Nichols, SHJ Chan, C Jiang, R Hao, PB Smith, J Cai, … MSystems 1 (5), 10.1128/msystems. 00070-16		2016
NMR-based metabolomics and its application in drug metabolism and cancer research L Zhang, E Hatzakis, AD Patterson Current Pharmacology Reports 2, 231-240		2016
Expression of the aryl hydrocarbon receptor contributes to the establishment of intestinal microbial community structure in mice IA Murray, RG Nichols, L Zhang, AD Patterson, GH Perdew Scientific Reports 6 (1), 33969		2016
Editor’s highlight: Perfluorooctane sulfonate-choline ion pair formation: A potential mechanism modulating hepatic steatosis and oxidative stress in mice L Zhang, P Krishnan, DJ Ehresman, PB Smith, M Dutta, BD Bagley, … Toxicological Sciences 153 (1), 186-197		2016
Metabolomics reveals altered lipid metabolism in a mouse model of endometriosis M Dutta, M Anitha, PB Smith, CR Chiaro, M Maan, K Chaudhury, … Journal of proteome research 15 (8), 2626-2633		2016
The ron receptor tyrosine kinase regulates macrophage heterogeneity and plays a protective role in diet-induced obesity, atherosclerosis, and hepatosteatosis S Yu, JN Allen, A Dey, L Zhang, G Balandaram, MJ Kennett, M Xia, … The Journal of Immunology 197 (1), 256-265		2016
Ron receptor tyrosine kinase plays a protective role in diet induced obesity and associated steatohepatitis JN Allen, L Zhang, S Yu, G Balandaram, JM Peters, AD Patterson, … The Journal of Immunology 196 (1_Supplement), 188.3-188.3		2016
Mass spectrometry–based metabolomics identifies longitudinal urinary metabolite profiles predictive of radiation-induced cancer JA Cook, GVR Chandramouli, MR Anver, AL Sowers, A Thetford, … Cancer research 76 (6), 1569-1577		2016
Impaired recovery from peritoneal inflammation in a mouse model of mild dietary zinc restriction BE Phillips, AK Geletzke, PB Smith, AB Podany, A Chacon, SL Kelleher, … Molecular nutrition & food research 60 (3), 672-681		2016
Antioxidant drug tempol promotes functional metabolic changes in the gut microbiota J Cai, L Zhang, RA Jones, JB Correll, E Hatzakis, PB Smith, FJ Gonzalez, … Journal of proteome research 15 (2), 563-571		2016
Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction C Jiang, C Xie, Y Lv, J Li, KW Krausz, J Shi, CN Brocker, D Desai, … Nature communications 6 (1), 10166		2015
Microbiota-dependent hepatic lipogenesis mediated by stearoyl CoA desaturase 1 (SCD1) promotes metabolic syndrome in TLR5-deficient mice V Singh, B Chassaing, L Zhang, B San Yeoh, X Xiao, M Kumar, MT Baker, … Cell metabolism 22 (6), 983-996		2015
Kernel approaches for differential expression analysis of mass spectrometry-based metabolomics data X Zhan, AD Patterson, D Ghosh BMC bioinformatics 16, 1-13		2015
Lack of soluble fiber drives diet-induced adiposity in mice B Chassaing, J Miles-Brown, M Pellizzon, E Ulman, M Ricci, L Zhang, … American Journal of Physiology-Gastrointestinal and Liver Physiology 309 (7 …		2015
Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles TD Hubbard, IA Murray, WH Bisson, TS Lahoti, K Gowda, SG Amin, … Scientific reports 5 (1), 12689		2015
Metabolomics reveals that aryl hydrocarbon receptor activation by environmental chemicals induces systemic metabolic dysfunction in mice L Zhang, E Hatzakis, RG Nichols, R Hao, J Correll, PB Smith, CR Chiaro, … Environmental science & technology 49 (13), 8067-8077		2015
Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation L Zhang, RG Nichols, J Correll, IA Murray, N Tanaka, PB Smith, … Environmental health perspectives 123 (7), 679-688		2015
Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine-and choline-deficient diet N Tanaka, S Takahashi, Y Zhang, KW Krausz, PB Smith, AD Patterson, … Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1852 (7 …		2015
Inhibition of farnesoid X receptor signaling shows beneficial effects in human obesity FJ Gonzalez, C Jiang, WH Bisson, AD Patterson Journal of hepatology 62 (6), 1234-1236		2015
Inflammation and gut microbiota-induced hepatic lipogenesis drives metabolic syndrome in TLR5 deficient mice (HUM1P. 310) V Singh, B Chassaing, L Zhang, BS Yeoh, X Xiao, K Harvatine, J Ntambi, … The Journal of Immunology 194 (1_Supplement), 52.35-52.35		2015
Host vitamin D status is dependent on the microbiota.(MUC9P. 747) S Bora, P Smith, A Patterson, M Cantorna The Journal of Immunology 194 (1_Supplement), 205.11-205.11		2015
Modulation of colon cancer by nutmeg F Li, XW Yang, KW Krausz, RG Nichols, W Xu, AD Patterson, FJ Gonzalez Journal of proteome research 14 (4), 1937-1946		2015
Quantitative Analysis of Purine Nucleotides Indicates That Purinosomes Increase de Novo Purine Biosynthesis*♦ H Zhao, CR Chiaro, L Zhang, PB Smith, CY Chan, AM Pedley, RJ Pugh, … Journal of Biological Chemistry 290 (11), 6705-6713		2015
Inhibitors of the farnesoid x receptor and uses in medicine FJ Gonzalez, C Jiang, XIE Cen, AD PATTERSON, F Li, JB Mitchell, …		2015
Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease C Jiang, C Xie, F Li, L Zhang, RG Nichols, KW Krausz, J Cai, Y Qi, … The Journal of clinical investigation 125 (1), 386-402		2015
Aryl hydrocarbon receptor ligands in cancer: friend and foe IA Murray, AD Patterson, GH Perdew Nature Reviews Cancer 14 (12), 801-814		2014
Species-specific ant brain manipulation by a specialized fungal parasite C De Bekker, LE Quevillon, PB Smith, KR Fleming, D Ghosh, … BMC evolutionary biology 14, 1-12		2014
Microbial determinants of biochemical individuality and their impact on toxicology and pharmacology AD Patterson, PJ Turnbaugh Cell metabolism 20 (5), 761-768		2014
Crucial role of macrophage selenoproteins in experimental colitis N Kaushal, AK Kudva, AD Patterson, C Chiaro, MJ Kennett, D Desai, … The Journal of Immunology 193 (7), 3683-3692		2014
Noninvasive urinary metabolomic profiling identifies diagnostic and prognostic markers in lung cancer EA Mathé, AD Patterson, M Haznadar, SK Manna, KW Krausz, … Cancer research 74 (12), 3259-3270		2014
Heterogeneous mechanisms underlying behavioral manipulation by a fungal parasite C De Bekker, LE Quevillon, PB Smith, AD Patterson, DP Hughes INTEGRATIVE AND COMPARATIVE BIOLOGY 54, E50-E50		2014
Metabolomics KR Belton, JB Correll, AD Patterson Future Science Ltd		2014
Identification of serum insulin-like growth factor binding protein 1 as diagnostic biomarker for early-stage alcohol-induced liver disease HH Li, K Doiron, AD Patterson, FJ Gonzalez, AJ Fornace Jr Journal of translational medicine 11 (1), 1-8		2013
Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity F Li, C Jiang, KW Krausz, Y Li, I Albert, H Hao, KM Fabre, JB Mitchell, … Nature communications 4 (1), 2384		2013
Metabolomics reveals the heterogeneous secretome of two entomopathogenic fungi to ex vivo cultured insect tissues C de Bekker, PB Smith, AD Patterson, DP Hughes PLoS One 8 (8), e70609		2013
Metabolomics reveals that tumor xenografts induce liver dysfunction F Li, AD Patterson, KW Krausz, C Jiang, H Bi, AL Sowers, JA Cook, … Molecular & Cellular Proteomics 12 (8), 2126-2135		2013
Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity AD Patterson, BA Carlson, F Li, JA Bonzo, MH Yoo, KW Krausz, M Conrad, … Chemical research in toxicology 26 (7), 1088-1096		2013
Biochemistry and physiology of the β class carbonic anhydrase (Cpb) from Clostridium perfringens strain 13 RSS Kumar, W Hendrick, JB Correll, AD Patterson, SB Melville, JG Ferry Journal of bacteriology 195 (10), 2262-2269		2013
White Button Mushrooms Increase Microbial Diversity and Accelerate the Resolution of Citrobacter rodentium Infection in Mice J Varshney, JH Ooi, BM Jayarao, I Albert, J Fisher, RL Smith, … The Journal of nutrition 143 (4), 526-532		2013
Stable isotope-and mass spectrometry-based metabolomics as tools in drug metabolism: a study expanding tempol pharmacology F Li, X Pang, KW Krausz, C Jiang, C Chen, JA Cook, MC Krishna, … Journal of proteome research 12 (3), 1369-1376		2013
Metabolomics: an essential tool to understand the function of peroxisome proliferator–activated receptor alpha JE Montanez, JM Peters, JB Correll, FJ Gonzalez, AD Patterson Toxicologic pathology 41 (2), 410-418		2013
Network Analysis of a Pkd1-Mouse Model of Autosomal Dominant Polycystic Kidney Disease Identifies HNF4α as a Disease Modifier LF Menezes, F Zhou, AD Patterson, KB Piontek, KW Krausz, FJ Gonzalez, … PLoS genetics 8 (11), e1003053		2012
Metabolomics identifies an inflammatory cascade involved in dioxin-and diet-induced steatohepatitis T Matsubara, N Tanaka, KW Krausz, SK Manna, DW Kang, ER Anderson, … Cell metabolism 16 (5), 634-644		2012
Radiation metabolomics. 5. Identification of urinary biomarkers of ionizing radiation exposure in nonhuman primates by mass spectrometry-based metabolomics CH Johnson, AD Patterson, KW Krausz, JF Kalinich, JB Tyburski, … Radiation research 178 (4), 328-340		2012
Novel metabolites and roles for α-tocopherol in humans and mice discovered by mass spectrometry–based metabolomics^– CH Johnson, O Slanař, KW Krausz, DW Kang, AD Patterson, JH Kim, … The American journal of clinical nutrition 96 (4), 818-830		2012
Role of the Ah receptor in homeostatic control of fatty acid synthesis in the liver R Tanos, IA Murray, PB Smith, A Patterson, GH Perdew Toxicological Sciences 129 (2), 372-379		2012
Metabolomics reveals an essential role for peroxisome proliferator-activated receptor α in bile acid homeostasis [S] F Li, AD Patterson, KW Krausz, N Tanaka, FJ Gonzalez Journal of lipid research 53 (8), 1625-1635		2012
PPARα-dependent induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity AD Patterson, YM Shah, T Matsubara, KW Krausz, FJ Gonzalez Hepatology (Baltimore, Md.) 56 (1), 281		2012
Abcb11 deficiency induces cholestasis coupled to impaired β-fatty acid oxidation in mice Y Zhang, F Li, AD Patterson, Y Wang, KW Krausz, G Neale, S Thomas, … Journal of Biological Chemistry 287 (29), 24784-24794		2012
Peroxisome proliferator‐activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen‐induced liver toxicity AD Patterson, YM Shah, T Matsubara, KW Krausz, FJ Gonzalez Hepatology 56 (1), 281-290		2012
Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis N Tanaka, T Matsubara, KW Krausz, AD Patterson, FJ Gonzalez Hepatology 56 (1), 118-129		2012
Aryl hydrocarbon receptor regulates the cholesterol biosynthetic pathway in a dioxin response element‐independent manner R Tanos, RD Patel, IA Murray, PB Smith, AD Patterson, GH Perdew Hepatology 55 (6), 1994-2004		2012
Metabolomics reveals the metabolic map of procainamide in humans and mice F Li, AD Patterson, KW Krausz, B Dick, FJ Frey, FJ Gonzalez, JR Idle Biochemical pharmacology 83 (10), 1435-1444		2012
Xenobiotic metabolomics: major impact on the metabolome CH Johnson, AD Patterson, JR Idle, FJ Gonzalez Annual review of pharmacology and toxicology 52, 37-56		2012
Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling AD Patterson, O Maurhofer, D Beyoğlu, C Lanz, KW Krausz, T Pabst, … Cancer research 71 (21), 6590-6600		2011
UPLC–MS-based urine metabolomics reveals indole-3-lactic acid and phenyllactic acid as conserved biomarkers for alcohol-induced liver disease in the Ppara-null mouse model SK Manna, AD Patterson, Q Yang, KW Krausz, JR Idle, AJ Fornace Jr, … Journal of proteome research 10 (9), 4120-4133		2011
PPAR action in insulin resistance unraveled by metabolomics: potential clinical implications AD Patterson, JM Peters Genome Medicine 3 (8), 1-2		2011
A Cyp2a polymorphism predicts susceptibility to NNK-induced lung tumorigenesis in mice MC Hollander, X Zhou, CR Maier, AD Patterson, X Ding, PA Dennis Carcinogenesis 32 (8), 1279-1284		2011
Metabolomics reveals attenuation of the SLC6A20 kidney transporter in nonhuman primate and mouse models of type 2 diabetes mellitus AD Patterson, JA Bonzo, F Li, KW Krausz, GS Eichler, S Aslam, X Tigno, … Journal of biological chemistry 286 (22), 19511-19522		2011
A comprehensive understanding of thioTEPA metabolism in the mouse using UPLC–ESI-QTOFMS-based metabolomics F Li, AD Patterson, CC Höfer, KW Krausz, FJ Gonzalez, JR Idle Biochemical pharmacology 81 (8), 1043-1053		2011
Lithocholic acid disrupts phospholipid and sphingolipid homeostasis leading to cholestasis in mice T Matsubara, N Tanaka, AD Patterson, JY Cho, KW Krausz, FJ Gonzalez Hepatology 53 (4), 1282-1293		2011
Radiation metabolomics. 4. UPLC-ESI-QTOFMS-Based metabolomics for urinary biomarker discovery in gamma-irradiated rats CH Johnson, AD Patterson, KW Krausz, C Lanz, DW Kang, H Luecke, … Radiation research 175 (4), 473-484		2011
Metabolomics Identifies Novel Hnf1α-Dependent Physiological Pathways in Vivo JA Bonzo, AD Patterson, KW Krausz, FJ Gonzalez Molecular endocrinology 24 (12), 2343-2355		2010
Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC–ESI-QTOFMS-based metabolomics F Li, AD Patterson, CC Höfer, KW Krausz, FJ Gonzalez, JR Idle Biochemical pharmacology 80 (7), 1063-1074		2010
Identification of Noninvasive Biomarkers for Alcohol-Induced Liver Disease Using Urinary Metabolomics and the Ppara-null Mouse SK Manna, AD Patterson, Q Yang, KW Krausz, H Li, JR Idle, … Journal of proteome research 9 (8), 4176-4188		2010
Xenobiotic metabolism: a view through the metabolometer AD Patterson, FJ Gonzalez, JR Idle Chemical research in toxicology 23 (5), 851-860		2010
The role of mass spectrometry‐based metabolomics in medical countermeasures against radiation AD Patterson, C Lanz, FJ Gonzalez, JR Idle Mass spectrometry reviews 29 (3), 503-521		2010
Detection of radiation-exposure biomarkers by differential mobility prefiltered mass spectrometry (DMS–MS) SL Coy, EV Krylov, BB Schneider, TR Covey, DJ Brenner, JB Tyburski, … International journal of mass spectrometry 291 (3), 108-117		2010
Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in Alzheimer’s disease MH Yoo, X Gu, XM Xu, JY Kim, BA Carlson, AD Patterson, H Cai, … Antioxidants & redox signaling 12 (7), 819-827		2010
Biomarkers for detecting radiation exposure: methods and uses thereof JR Idle, FJ Gonzalez, JB Tyburski, KW Krausz, AD Patterson US Patent App. 12/121,208		2009
A metabolomic perspective of small molecule toxicity AD Patterson, JR Idle General, Applied and Systems Toxicology		2009
Human urinary metabolomic profile of PPARα induced fatty acid β-oxidation AD Patterson, O Slanar, KW Krausz, F Li, CC Höfer, F Perlik, … Journal of proteome research 8 (9), 4293-4300		2009
Radiation metabolomics. 3. Biomarker discovery in the urine of gamma-irradiated rats using a simplified metabolomics protocol of gas chromatography-mass spectrometry combined … C Lanz, AD Patterson, J Slavík, KW Krausz, M Ledermann, FJ Gonzalez, … Radiation research 172 (2), 198-212		2009
Radiation metabolomics. 2. Dose-and time-dependent urinary excretion of deaminated purines and pyrimidines after sublethal gamma-radiation exposure in mice JB Tyburski, AD Patterson, KW Krausz, J Slavík, AJ Fornace Jr, … Radiation research 172 (1), 42-57		2009
Fenofibrate metabolism in the cynomolgus monkey using ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry-based metabolomics A Liu, AD Patterson, Z Yang, X Zhang, W Liu, F Qiu, H Sun, KW Krausz, … Drug metabolism and disposition 37 (6), 1157-1163		2009
Radiation metabolomics. 1. Identification of minimally invasive urine biomarkers for gamma-radiation exposure in mice JB Tyburski, AD Patterson, KW Krausz, J Slavík, AJ Fornace Jr, … Radiation research 170 (1), 1-14		2008
UPLC-ESI-TOFMS-based metabolomics and gene expression dynamics inspector self-organizing metabolomic maps as tools for understanding the cellular response to ionizing radiation AD Patterson, H Li, GS Eichler, KW Krausz, JN Weinstein, AJ Fornace, … Analytical chemistry 80 (3), 665-674		2008
Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication MH Yoo, XM Xu, BA Carlson, AD Patterson, VN Gladyshev, DL Hatfield PloS one 2 (10), e1112		2007
The nuclear export signal of splicing factor Uap56p interacts with nuclear pore-associated protein Rae1p for mRNA export in Schizosaccharomyces pombe AG Thakurta, SP Selvanathan, AD Patterson, G Gopal, R Dhar Journal of Biological Chemistry 282 (24), 17507-17516		2007
Gadd34 requirement for normal hemoglobin synthesis AD Patterson, MC Hollander, GF Miller, AJ Fornace Jr Molecular and cellular biology 26 (5), 1644-1653		2006
Neural tube development requires the cooperation of p53‐and Gadd45a‐associated pathways AD Patterson, J Hildesheim, AJ Fornace Jr, MC Hollander Birth Defects Research Part A: Clinical and Molecular Teratology 76 (2), 129-132		2006
Deletion of XPC leads to lung tumors in mice and is associated with early events in human lung carcinogenesis MC Hollander, RT Philburn, AD Patterson, S Velasco-Miguel, … Proceedings of the National Academy of Sciences 102 (37), 13200-13205		2005
Genomic instability in Gadd45a-/-cells is coupled with S-phase checkpoint defects MC Hollander, RT Philburn, AD Patterson2, MA Wyatt, AJ Fornace, Jr Cell Cycle 4 (5), 704-709		2005
Gadd45a acts as a modifier locus for lymphoblastic lymphoma MC Hollander, AD Patterson, JM Salvador, MR Anver, SP Hunger, … Leukemia 19 (5), 847-850		2005
Intra-and intermolecular domain interactions of the C-terminal GTPase effector domain of the multimeric dynamin-like GTPase Drp1 PP Zhu, A Patterson, J Stadler, DP Seeburg, M Sheng, C Blackstone Journal of Biological Chemistry 279 (34), 35967-35974		2004
Cellular localization, oligomerization, and membrane association of the hereditary spastic paraplegia 3A (SPG3A) protein atlastin PP Zhu, A Patterson, B Lavoie, J Stadler, M Shoeb, R Patel, C Blackstone Journal of Biological Chemistry 278 (49), 49063-49071		2003
A nucleotide excision repair master-switch: p53 regulated coordinate introduction of global genomic repair genes SA Amundson, A Patterson, KT Do, AJ Fornace, Jr Cancer biology & therapy 1 (2), 145-149		2002
Dimethylbenzanthracene Carcinogenesis in Gadd45a-null Mice Is Associated with Decreased DNA Repair and Increased Mutation Frequency MC Hollander, O Kovalsky, JM Salvador, KE Kim, AD Patterson, … Cancer research 61 (6), 2487-2491		2001

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