Integrative Structural Biology of Biomolecular Complexes

Protein dynamics is central to biological function. Our group’s research interests are in probing protein dynamics in cell signalling with a focus on allostery, conformational dynamics of viral capsids, transmembrane receptor signalling and targeted drug discovery.

Protein dynamics is probed by multiple biophysical tools including amide hydrogen/deuterium exchange mass spectrometry (HDX-MS) and ion mobility mass spectrometry (IM-MS). Our goal is to integrate protein dynamics with structural tools for describing biological function.