Anand Lab

Integrative Structural Biology Lab

Publications

 

2023:

  • Venkatakrishnan V, Ghode A, Tulsian NK, Anand GS. Impaired cAMP processivity by phosphodiesterase-protein kinase A complexes in acrodysostosis. Front Mol Biosci. 2023;10:1202268. [PUBMED]
  • Sacerdoti M, Gross LZF, Riley AM, et al. Modulation of the substrate specificity of the kinase PDK1 by distinct conformations of the full-length protein. Sci Signal. 2023;16(789):eadd3184. [PUBMED]
  • Zuzic L, Marzinek JK, Anand GS, Warwicker J, Bond PJ. A pH-dependent cluster of charges in a conserved cryptic pocket on flaviviral envelopes. Elife. 2023;12:e82447. [PUBMED]
  • Braet SM, Buckley TSC, Venkatakrishnan V, Dam KA, Bjorkman PJ, Anand GS. Timeline of changes in spike conformational dynamics in emergent SARS-CoV-2 variants reveal progressive stabilization of trimer stalk with altered NTD dynamics. Elife. 2023;12:e82584. [PUBMED]
  • Samsudin F, Raghuvamsi P, Petruk G, et al. SARS-CoV-2 spike protein as a bacterial lipopolysaccharide delivery system in an overzealous inflammatory cascade. J Mol Cell Biol. 2023;14(9):mjac058.[PUBMED]

2022:

  • Khan SH, Braet SM, Koehler SJ, Elacqua E, Anand GS, Okafor CD. Ligand-induced shifts in conformational ensembles that describe transcriptional activation. Elife. 2022;11:e80140. [PUBMED]
  • Tantirimudalige SN, Raghuvamsi PV, Sharma KK, Wei Bao JC, Anand GS, Wohland T. The ganglioside GM1a functions as a coreceptor/attachment factor for dengue virus during infection. J Biol Chem. 2022;298(11):102570. [PUBMED]
  • Tantirimudalige S, Buckley TSC, Chandramohan A, Richter RM, Ziegler C, Anand GS. Hyperosmotic Stress Allosterically Reconfigures Betaine Binding Pocket in BetP. J Mol Biol. 2022;434(17):167747.[PUBMED]
  • Zuzic L, Samsudin F, Shivgan AT, et al. Uncovering cryptic pockets in the SARS-CoV-2 spike glycoprotein. Structure. 2022;30(8):1062-1074.e4. [PUBMED]
  • Liu H, Peck XY, Choong YK, et al. Identification of putative binding interface of PI(3,5)P2 lipid on rice black-streaked dwarf virus (RBSDV) P10 protein. Virology. 2022;570:81-95. [PUBMED]

2021:

  • Tulsian NK, Sin VJ, Koh HL, Anand GS. Development of Phosphodiesterase-Protein-Kinase Complexes as Novel Targets for Discovery of Inhibitors with Enhanced Specificity. Int J Mol Sci. 2021;22(10):5242. [PUBMED]
  • Lim XX, Shu B, Zhang S, et al. Human antibody C10 neutralizes by diminishing Zika but enhancing dengue virus dynamics. Cell. 2021;184(25):6067-6080.e13. [PUBMED]

  • Raghuvamsi PV, Tulsian NK, Samsudin F, Qian X, Purushotorman K, Yue G, Kozma MM, Hwa WY, Lescar J, Bond PJ, MacAry PA, Anand GS. SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets. eLife 2021 Feb 8;10:e63646. [PUBMED]

  • Yong XE, Raghuvamsi PV, Anand GS, Wohland T, Sharma KK. Dengue virus strain 2 capsid protein switches the annealing pathway and reduces intrinsic dynamics of the conserved 5′ untranslated region. RNA Biol. 2021 Jan 7:1-14. [PUBMED]

2020:

  • Akimoto M , Yu T , Moleschi K , Van K , Anand GS , Melacini G . An NMR based phosphodiesterase assay. Chem Commun (Camb). 2020 Jul 25;56(58):8091-8094. [PUBMED]

 

  • Ghode A, Gross LZF, Tee WV, Guarnera E, Berezovsky IN, Biondi RM, Anand GS. Synergistic Allostery in Multiligand-Protein Interactions. Biophys J. 2020 Nov 3;119(9):1833-1848. [PUBMED]

 

  • Sin VJ, Anand GS, Koh HL. Botanical Medicine and Natural Products Used for Erectile Dysfunction. Sex Med Rev. 2020 Dec 1:S2050-0521(20)30114-1. [PUBMED]

 

  • Kenney LJ, Anand GS. EnvZ/OmpR Two-Component Signaling: An Archetype System That Can Function Noncanonically. EcoSal Plus. 2020 Jan;9(1):10.1128/ecosalplus. [PUBMED]

 

  • Tulsian NK, Ghode A, Anand GS. Adenylate control in cAMP signaling: implications for adaptation in signalosomes. Biochem J. 2020 Aug 28;477(16):2981-2998. [PUBMED]

 

  • Chakraborty R, Fan JS, Lai CC, Raghuvamsi PV, Chee PX, Anand GS, Yang D. Structural Basis of Oligomerization of N-Terminal Domain of Spider Aciniform Silk Protein. Int J Mol Sci. 2020 Jun 23;21(12):4466. [PUBMED]

2019:

  • Masson GR, Burke JE, Ahn NG, Anand GS, Borchers C, Brier S, Bou-Assaf GM, Engen JR, Englander SW, Faber J, Garlish R, Griffin PR, Gross ML, Guttman M, Hamuro Y, Heck AJR, Houde D, Iacob RE, Jørgensen TJD, Kaltashov IA, Klinman JP, Konermann L, Man P, Mayne L, Pascal BD, Reichmann D, Skehel M, Snijder J, Strutzenberg TS, Underbakke ES, Wagner C, Wales TE, Walters BT, Weis DD, Wilson DJ, Wintrode PL, Zhang Z, Zheng J, Schriemer DC, Rand KD. Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments. Nat Methods. 2019 Jul;16(7):595-602. [PUBMED]

 

  • Hudgens JW, Gallagher ES, Karageorgos I, Anderson KW, Filliben JJ, Huang RY, Chen G, Bou-Assaf GM, Espada A, Chalmers MJ, Harguindey E, Zhang HM, Walters BT, Zhang J, Venable J, Steckler C, Park I, Brock A, Lu X, Pandey R, Chandramohan A, Anand GS, Nirudodhi SN, Sperry JB, Rouse JC, Carroll JA, Rand KD, Leurs U, Weis DD, Al-Naqshabandi MA, Hageman TS, Deredge D, Wintrode PL, Papanastasiou M, Lambris JD, Li S, Urata S. Interlaboratory Comparison of Hydrogen-Deuterium Exchange Mass Spectrometry Measurements of the Fab Fragment of NISTmAb. Anal Chem. 2019 Jun 4;91(11):7336-7345. [PUBMED]

 

  • Ramesh R, Lim XX, Raghuvamsi PV, Wu C, Wong SM, Anand GS. Uncovering metastability and disassembly hotspots in whole viral particles. Prog Biophys Mol Biol. 2019 May;143:5-12. [PUBMED]

 

  • Sharma KK, Lim XX, Tantirimudalige SN, Gupta A, Marzinek JK, Holdbrook D, Lim XYE, Bond PJ, Anand GS, Wohland T. Infectivity of Dengue Virus Serotypes 1 and 2 Is Correlated with E-Protein Intrinsic Dynamics but Not to Envelope Conformations. Structure. 2019 Apr 2;27(4):618-630. [PUBMED]

 

  • Kielkopf CS, Ghosh M, Anand GS, Brown SHJ. HDX-MS reveals orthosteric and allosteric changes in apolipoprotein-D structural dynamics upon binding of progesterone. Protein Sci. 2019 Feb;28(2):365-374. [PUBMED]

 

  • Wirawan M, Fibriansah G, Marzinek JK, Lim XX, Ng TS, Sim AYL, Zhang Q, Kostyuchenko VA, Shi J, Smith SA, Verma CS, Anand G, Crowe JE Jr, Bond PJ, Lok SM. Mechanism of Enhanced Immature Dengue Virus Attachment to Endosomal Membrane Induced by prM Antibody. Structure. 2019 Feb 5;27(2):253-267. [PUBMED]

 

  • Ghosh M, Wang LC, Huber RG, Gao Y, Morgan LK, Tulsian NK, Bond PJ, Kenney LJ, Anand GS. Engineering an Osmosensor by Pivotal Histidine Positioning within Disordered Helices. Structure. 2019 Feb 5;27(2):302-314. [PUBMED]

2018:

  • Srivastava AK, Orosa B, Singh P, Cummins I, Walsh C, Zhang C, Grant M, Roberts MR, Anand GS, Fitches E, Sadanandom A. SUMO Suppresses the Activity of the Jasmonic Acid Receptor CORONATINE INSENSITIVE1. Plant Cell. 2018 Sep;30(9):2099-2115. [PUBMED]

 

  • Kao C, Chandna R, Ghode A, Dsouza C, Chen M, Larsson A, Lim SH, Wang M, Cao Z, Zhu Y, Anand GS. Proapoptotic Cyclic Peptide BC71 Targets Cell-Surface GRP78 and Functions as an Anticancer Therapeutic in Mice. EBioMedicine. 2018 Jun. [PUBMED]

 

  • Boon PL, Saw WG, Lim XX, Raghuvamsi PV, Huber RG, Marzinek JK, Holdbrook DA, Anand GS, Grüber G, Bond PJ. Partial Intrinsic Disorder Governs the Dengue Capsid Protein Conformational Ensemble. ACS Chemical Biology. 2018 May 24;13(6):1621-30. [PUBMED]

2017:

  • Lim XX, Chandramohan A, Lim XY, Crowe Jr JE, Lok SM, Anand GS. Epitope and Paratope Mapping Reveals Temperature-Dependent Alterations in the Dengue-Antibody Interface. Structure. 2017 Sep 5;25(9):1391-402. [PUBMED]

 

  • Tulsian NK, Krishnamurthy S, Anand GS. Channeling of cAMP in PDE-PKA complexes promotes signal adaptation. Biophysical Journal. 2017 Jun 20;112(12):2552-66. [PUBMED]

 

  • Chandramohan A, Tulsian NK, Anand GS. Dissecting Orthosteric Contacts for a Reverse-Fragment-Based Ligand Design. Analytical Chemistry. 2017 Jul 14;89(15):7876-85. [PUBMED]

 

  • Ghosh M, Wang LC, Ramesh R, Morgan LK, Kenney LJ, Anand GS. Lipid-Mediated Regulation of Embedded Receptor Kinases via Parallel Allosteric Relays. Biophysical Journal. 2017 Feb 28;112(4):643-54. [PUBMED]

 

  • Lim XX, Chandramohan A, Lim XY, Bag N, Sharma KK, Wirawan M, Wohland T, Lok SM, Anand GS. Conformational changes in intact dengue virus reveal serotype-specific expansion. Nature Communications. 2017 Feb 10;8:14339. [PUBMED]

2016:

  • Ali N, Ling N, Krishnamurthy S, Oakhill JS, Scott JW, Stapleton DI, Kemp BE, Anand GS, Gooley PR. β-subunit myristoylation functions as an energy sensor by modulating the dynamics of AMP-activated Protein Kinase. Scientific Reports. 2016;6. [PUBMED]

 

  • Husain N, Tulsian NK, Wang LC, Anand GS, Sivaraman J. Ligand-mediated changes in conformational dynamics of NpmA: implications for ribosomal interactions. Scientific Reports. 2016;6. [PUBMED]

 

  • Chandramohan A, Krishnamurthy S, Larsson A, Nordlund P, Jansson A, Anand GS. Predicting allosteric effects from orthosteric binding in Hsp90-ligand interactions: Implications for Fragment-based drug design. PLoS Computational Biology. 2016 Jun 2;12(6):e1004840. [PUBMED]

2015:

  • Krishnamurthy S, Tulsian NK, Chandramohan A, Anand GS. Parallel Allostery by cAMP and PDE Coordinates Activation and Termination Phases in cAMP Signaling. Biophysical Journal. 2015 Sep 15;109(6):1251-63. [PUBMED]

2014:

  • Krishnamurthy S, Moorthy BS, Lim XX, Lim XS, Bharatham K, Tulsian NK, Mihalek I, Anand GS. Active site coupling in PDE: PKA complexes promotes resetting of mammalian cAMP signaling. Biophysical Journal. 2014 Sep 16;107(6):1426-40. [PUBMED]

 

  • Krishnamurthy S, Veesler D, Khayat R, Snijder J, Huang R, Heck AJ, Johnson J, Anand GS. Distinguishing direct binding interactions from allosteric effects in the protease–HK97 prohead I δ domain complex by amide H/D exchange mass spectrometry. Bacteriophage. 2014 Dec 15;4(4):e959816. [PUBMED]

 

  • Veesler D, Khayat R, Krishnamurthy S, Snijder J, Huang RK, Heck AJ, Anand GS, Johnson JE. Architecture of a dsDNA viral capsid in complex with its maturation protease. Structure. 2014 Feb 4;22(2):230-7. [PUBMED]

2013:

  • Krishnamurthy S, Moorthy BS, Liqin L, Anand GS. Dynamics of phosphodiesterase-induced cAMP dissociation from protein kinase A: capturing transient ternary complexes by HDXMS. Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics. 2013 Jun 30;1834(6):1215-21. [PUBMED]

2012:

  • Wang LC, Morgan LK, Godakumbura P, Kenney LJ, Anand GS. The inner membrane histidine kinase EnvZ senses osmolality via helix‐coil transitions in the cytoplasm. The EMBO Journal. 2012 May 30;31(11):2648-59. [PUBMED]

 

  • Nambi S, Badireddy S, Visweswariah SS, Anand GS. Cyclic AMP-induced conformational changes in mycobacterial protein acetyltransferases. Journal of Biological Chemistry. 2012 May 25;287(22):18115-29. [PUBMED]

 

  • Moorthy BS, Anand GS. Multistate allostery in response regulators: phosphorylation and mutagenesis activate RegA via alternate modes. Journal of Molecular Biology. 2012 Apr 13;417(5):468-87. [PUBMED]

2011:

  • Badireddy S, Yunfeng G, Ritchie M, Akamine P, Wu J, Kim CW, Taylor SS, Qingsong L, Swaminathan K, Anand GS. Cyclic AMP analog blocks kinase activation by stabilizing inactive conformation: conformational selection highlights a new concept in allosteric inhibitor design. Molecular & Cellular Proteomics. 2011 Mar 1;10(3):M110-004390. [PUBMED]

 

  • Moorthy BS, Gao Y, Anand GS. Phosphodiesterases catalyze hydrolysis of cAMP-bound to regulatory subunit of protein kinase A and mediate signal termination. Molecular & Cellular Proteomics. 2011 Feb 1;10(2):M110-002295. [PUBMED]

2010:

  • Anand GS, Krishnamurthy S, Bishnoi T, Kornev A, Taylor SS, Johnson DA. Cyclic AMP-and (Rp)-cAMPS-induced conformational changes in a complex of the catalytic and regulatory (RIα) subunits of cyclic AMP-dependent protein kinase. Molecular & Cellular Proteomics. 2010 Oct 1;9(10):2225-37. [PUBMED]

2009:

  • Sun Q, Collins R, Huang S, Holmberg-Schiavone L, Anand GS, Tan CH, Van-Den-Berg S, Deng LW, Moore PK, Karlberg T, Sivaraman J. Structural basis for the inhibition mechanism of human cystathionine γ-lyase, an enzyme responsible for the production of H2S. Journal of Biological Chemistry. 2009 Jan 30;284(5):3076-85. [PUBMED]
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