Publications

  1. Zeng H. and Liu, A. (2023) TMEM132A regulates mouse hindgut morphogenesis and caudal development, Development, in press. https://doi.org/10.1242/dev.201630.
  2. Wang, S., Liu, A., Yunchao Su, Y. and  Dong, Z. (2023) Deficiency of the planar cell polarity protein intu delays kidney repair and suppresses renal fibrosis after acute kidney injury. The American Journal of Pathology, 193:275-285. doi: 10.1016/j.ajpath.2022.12.006.
  3. Cheng, S.Y., Lauth, M. and Liu, A. (2022) Editorial: Hedgehog signaling pathway in development and cancer. Front. Cell Dev. Biol. 10:1010230. doi:10.3389/fcell.2022.1010230.
  4. Wang, Y., Molano, C. and Liu, A. (2022) Differential Expression of the Tmem132 Family Genes in the Developing Mouse Nervous System. Gene Expression Patterns, 45: 119257. https://doi.org/10.1016/j.gep.2022.119257. (among Biochemistry (6/12~13), Biochemical mechanism (5/24~25), BiochemRN: Other Biochemical Mechanisms (5/24~25), BiochemRN: Subject Matter (6/14~15); BioRN: Medical Genetics (5/21), Neurobiology (6/10~11), NeurosciRN (6/13~14,6/18~19), Genetics (6/12~13) and Developmental Neurobiology and Neuroregeneration (8/23~24, 9/5~6, 11/9~10, 1/14~15) top 10 papers on SSRN, 25 times total).  
  5. Chon, C., Chon, G, Matsui, Y., Zeng,H., Lai, Z-C. and Liu, A. (2021) Efficient multiplexed genome engineering with a polycistronic tRNA and CRISPR guide-RNA reveals an important role of detonator in reproduction of Drosophila melanogaster. PLoS ONE, 16(1): e0245454. https://doi.org/10.1371/journal.pone.0245454
  6. Rao-Bhatia, A., Zhu, M., Yin, W-C., Coquenlorge-Gallon, S., Zhang, X., Woo, J., Sun, Y., Dean, C.H., Liu, A., Chi-chung Hui, C-c., Shivdasani, R.A., McNeill, H., Hopyan, S. and Kim, T-H. (2020) Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development. Developmental Cell, 52: 647-658. https://doi.org/10.1016/j.devcel.2020.02.003
  7. Liu, A. (2019) Proteostasis in the Hedgehog signaling pathway. Seminars in Cell and Developmental Biology, 93: 153-163. DOI: 10.1016/j.semcdb.2018.10.009.
  8. Zhang,W., Yang, S-L., Yang, M., Herrlinger, S., Shao, Q., Collar, JL., Fierro, E., Shi, Y., Liu, A., Lu, H., Herring, BE., Zhao, Z., and Chen, J-F. (2019) Modeling microcephaly with cerebral organoids and mice reveals a WDR62-CEP170-KIF2A pathway promoting cilium disassembly for neural progenitor cell maintenance. Nature Communications, 10(1): 2612. doi: 10.1038/s41467-019-10497-2. PMCID: PMC6565620
  9. Wang, Y., Zeng, H. and Liu, A. (2019) Distinct Activities of Gli1 and Gli2 in the Absence of Ift88 and the Primary Cilia. J. Dev. Biol., 7(1): e5. https://doi.org/10.3390/jdb7010005. PMCID: PMC6473256
  10. Wang, S., Liu, A., Wu, G., Ding, H-F., Huang, S., Nahman, S. and Dong, Z. (2018) CPLANE protein Intu protects kidneys from ischemia-reperfusion injury by targeting STAT1 for degradation. Nature Communications, 9(1):1234. doi: 10.1038/s41467-018-03628-8. PMCID: PMC5964315.
  11. Agbu, SO., Liang, Y., Liu, A. and Anderson, KV. (2018) The Small GTPase RSG1 Controls a Final Step in Primary Cilia Initiation. Journal of Cell Biology, 217(1):413-427. doi: 10.1083/jcb.201604048. PMCID: PMC5748968.
  12. Cai, H. and Liu, A. (2017) Spop specifically regulates Gli3 activity and Shh signaling in dorsoventral patterning of the mouse neural tube. Developmental Biology, 432 (1): 72-85, DOI: 10.1016/j.ydbio.2017.04.002. PMCID: PMC5638672
  13. Yang, N., Leung, E., Liu, C., Li L., Eguether, T., Yao, XJ., Jones, EC., Norris, DA., Liu, A., Clark, RA., Roop, DR., Pazour, GJ., and Chen J. (2017) INTU is essential for oncogenic Hh signaling through regulating primary cilia formation in basal cell carcinoma (BCC). Oncogene, 36: 4997-5005. PMID: 28459465. DOI: 10.1038/onc.2017.117. PMCID: PMC5578876
  14. Cai H and Liu A. (2016) Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling. Proc Natl Acad Sci U S A., 113 (51): 14751-14756, PMID: 27930311 DOI:10.1073/pnas.1612520114. PMCID: PMC5187670
  15. Chang R, Petersen J R, Niswander L, Liu A. (2015) A hypomorphic allele reveals an important role of Inturned in mouse skeletal development. Developmental Dynamics, 244(6): 736-747. DOI 10.1002/dvdy.24272. PMCID: PMC4449324.
  16. Liu, J., Zeng, H. and Liu, A. (2015) The loss of HH responsiveness by a non-ciliary Gli2 variant. Development, 142: 1651-1660. doi:10.1242/dev.119669 (Highlighted article, recommended by Faculty of 1000). PMID: 25834022.
  17. Ye, X., Zeng, H., Ning, G., Reiter J. and Liu, A. (2014) C2cd3 regulates centriolar maturation and IFT protein recruitment essential for cilia formation. Proc Natl Acad Sci U S A., 111(6): 2164-2169. DOI:10.1073/pnas.1318737111. PMCID: PMC3926046.
  18. Wang, C., Low, W-C, Liu, A., and Wang, B (2013) Centrosomal Protein Dzip1 Regulates Hedgehog Signaling by Promoting Cytoplasmic Retention of Transcription Factor Gli3 and Affecting Ciliogenesis J. Biol. Chem., 288: 29518-29. doi: 10.1074/jbc.M113.492066. PMCID: PMC3795250
  19. Dai, D., Li, L., Huebner, A., Zeng, H., Guevara, E., Claypool, D., Liu, A., Chen, J. (2013) Planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia. Cell Death and Differentiation, 20: 130-8. doi: 10.1038/cdd.2012.104 PMCID: PMC3524640
  20. Liu A (2012) The Cilium-Dependent Hedgehog Signaling in Mammals. Cell Dev Biol ,1:e116. doi:10.4172/2168-9296.1000e116
  21. Liu, J., Heydeck, W., Zeng, H. and Liu, A. (2012) Dual Function of Suppressor of Fused in Shh Pathway Activation and Mouse Spinal Cord Patterning. Developmental Biology, 362: 141-153. DOI: 10.1016/j.ydbio.2011.11.022. PMID:22182519
  22. Ye, X and Liu, A. (2011) Hedgehog signaling: mechanism and evolution. Frontiers in Biology, 6(6): 504-521. DOI: 10.1007/s11515-011-1146-2
  23. Heydeck, W. and Liu, A. (2011) PCP effector proteins Inturned and Fuzzy play non-redundant roles in the patterning but not convergent extension of mammalian neural tube. Developmental Dynamics, 240 (8): 1938-1948. doi: 10.1002/dvdy.22696. PMID:
    1. 21761479
  24. Pyrgaki, C., Liu, A. and Niswander LA. (2011) Grainyhead-like 2 regulates neural tube closure by controlling adhesion molecules during neural fold fusion. Developmental Biology, 353 (1): 38-49. doi: 10.1016/j.ydbio.2011.02.027 PMCID: PMC3114429
  25. Zeng, H., Jia J. and Liu, A. (2010) Coordinated translocation of mammalian Gli proteins and Suppressor of Fused to the primary cilium. PLoS ONE 5(12): e15900. DOI: 10.1371/journal.pone.0015900. PMCID: PMC3012114
  26. Zeng, H., Hoover, AN.  and Liu, A. (2010) PCP effector gene Inturned is an important regulator of cilia formation and embryonic development in mammals. Developmental Biology, 339: 418-428. PMID:20067783.
  27. Heydeck, W., Zeng, H. and Liu, A. (2009) PCP effector gene Fuzzy regulates cilia formation and Hh signal transduction in mouse. Developmental Dynamics, 238: 3035-3042. PMID:19877275
  28. Jia, J., Kolterud, Å, Zeng, H., Hoover, AN., Teglund, S., Toftgård, R.  and Liu, A. (2009) Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia. Developmental Biology, 330: 452-460. (a Faculty of 1000 Must Read paper, top-five cited DB paper in May 2011) PMID:19371734. PMCID: PMC2687323
  29. Hoover, AN., Wynkoop, A., Zeng, H., Jia, J., Niswander, LA. and Liu, A. (2008) C2cd3 is required for cilia formation and Hedgehog signaling in the mouse. Development, 135: 4049-4058. PMCID: PMC3120044
  30. Liu, A., Niswander, LA. (2005) Bone morphogenetic protein signaling and vertebrate nervous system development. Nature reviews neuroscience, 6: 945-954. doi: 10.1038/nrn1805.PMID: 16340955
  31. Liu, A., Wang, B., Niswander, LA. (2005) Intraflagellar Transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development. 132: 3103-3111. doi: 10.1242/dev.01894. PMID: 15930098
  32. Liu, A., Wang, C., and Niswander, LA. (2005) Fibroblast Growth Factors in Development. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0003306]
  33. Huangfu, D., Liu, A., Rakeman, A., Murcia, N Niswander, LA., and Anderson, KV (2003) Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature, 426(6962): 83-87. doi: 10.1038/nature02061 (a Faculty of 1000 Exceptional paper)
  34. Liu, A., Li, JY., Bromleigh, C., Lao, Z, Niswander, LA, and Joyner, AL. (2003) FGF17b and FGF18 have different midbrain regulatory properties from FGF8b or activated FGF receptors. Development. 130(25): 6175-6185. (a Faculty of 1000 Exceptional paper) PMID: 14602678. DOI: 10.1242/dev.00845
  35. Liu, A. and Joyner AL. (2001) Patterning of the midbrain and cerebellum. Annual Review of Neuroscience, Vol. 24, 869-896. DOI: 10.1146/annurev.neuro.24.1.869 . PMID: 11520921
  36. Liu, A. and Joyner, AL. (2001) EN and GBX2 play essential roles downstream of FGF8 in patterning the mouse mid/hindbrain region. Development, 128:181-191. (a Faculty of 1000 Must Read paper). PMID: 11124114
  37. Joyner AL., Liu, A and Millet S. (2000) Otx2, Gbx2 and Fgf8 interact to position and maintain a mid/hindbrain organizer. Current Opinion in Cell Biology, 12: 736-741. DOI: 10.1016/s0955-0674(00)00161-7 . PMID: 11063941
  38. Liu, A., Losos, K. and Joyner, AL. (1999) FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate. Development, 126: 4827-4838. PMID: 10518499
  39. Liu, A., Joyner, AL. and Turnbull, DH. (1998) Alteration of limb and brain patterning by ultrasound-guided injection of Shh-expressing cells into mouse embryo. Mechanism of Development, 75: 107-115. DOI: 10.1016/s0925-4773(98)00090-2 . PMID: 9739117.