Our lab works to attain a molecular level understanding of RNA in biology. We find RNA fascinating because it is a both a structural and informatic molecule. Because it is single stranded, RNA folds back on itself. This leads it to adopt simple secondary structures such as stem-loops. RNA can also form complex tertiary structures with clefts that bind small molecules specifically and tightly (riboswitches) and catalyze reactions (ribozymes). This diversity of structures gives rise to diversity of functions including the ability of RNA to regulate genes.
On the pages in this Research section of this site you will find an overview of each project, a list of methods applied, group members currently working on a project, a list of collaborators, recent publications, some review articles to introduce the field, and a complete list of our publications in that area.
Please contact Phil with your interests.