See google scholar for an updated and comprehensive list, or Penn State profile for mostly outdated information.

Last updated 8/2024

Research Topics:

Cerebellar Output Pathways
Cerebellar Function/Physiology
Pathophysiology/Clinically Relevant
Other Fun Projects

* denotes shared authorship
# denotes corresponding author

Cerebellar Output Pathways

Characterization of direct Purkinje cell outputs to the brainstem (2024)

Christopher H. Chen*#, Zhiyi Yao*, Shuting Wu, Wade G. Regehr#

Elife bioRxiv

A Purkinje cell to parabrachial nucleus pathway enables broad cerebellar influence over the forebrain (2023)

Christopher H. Chen, Leannah N. Newman*, Amanda P. Stark*, Katherine E. Bond, Dawei Zhang, Stefano Nardone, Charles R. Vanderburg, Naeem M. Nadaf, Zhiyi Yao, Kefiloe Mutume, Isabella Flaquer, Bradford B. Lowell, Evan Z. Macosko, Wade G. Regehr

Nature Neuroscience bioRxiv

Cerebellar modulation of the reward circuitry and social behavior (2019)

Ilaria Carta*, Christopher H Chen*, Amanda L Schott, Schnaude Dorizan, Kamran Khodakhah

Science

Short latency cerebellar modulation of the basal ganglia (2014)

Christopher H Chen, Rachel Fremont, Eduardo E Arteaga-Bracho, Kamran Khodakhah

Nature Neuroscience

Cerebellar Function/Physiology

Implications of variable synaptic weights for rate and temporal coding of cerebellar outputs (2023)

Shuting Wu, Asem Wardak, Mehak M Khan, Christopher H Chen, Wade G Regehr

Elife bioRxiv

Cerebellar granule cell signaling is indispensable for normal motor performance (2023)

Joon-Hyuk Lee, Mehak M Khan, Amanda P Stark, Soobin Seo, Aliya Norton, Zhiyi Yao, Christopher H Chen, Wade G Regehr

Cell Reports

Unusually slow spike frequency adaptation in deep cerebellar nuclei neurons preserves linear transformations on the subsecond timescale (2022)

Mehak M Khan, Shuting Wu, Christopher H Chen, Wade G Regehr

Journal of Neuroscience bioRxiv

Climbing fiber synapses rapidly and transiently inhibit neighboring Purkinje cells via ephaptic coupling (2020)

Kyung-Seok Han*, Christopher H Chen*, Mehak M Khan, Chong Guo, Wade G Regehr

Nature Neuroscience

Cerebellar Purkinje cell activity modulates aggressive behavior (2020)

Skyler L Jackman, Christopher H Chen, Heather L Offermann, Iain R Drew, Bailey M Harrison, Anna M Bowman, Katelyn M Flick, Isabella Flaquer, Wade G Regehr

Elife

Ephaptic coupling promotes synchronous firing of cerebellar Purkinje cells (2018)

Kyung-Seok Han, Chong Guo, Christopher H Chen, Laurens Witter, Tomas Osorno, Wade G Regehr

Neuron

Pathophysiology/Clinically Relevant

Mechanism of stress-induced attacks in an episodic neurologic disorder (2022)

Heather D Snell, Ariel Vitenzon, Esra Tara, Chris Chen, Jaafar Tindi, Bryen A Jordan, Kamran Khodakhah

Science Advances

Selective expression of mutant huntingtin during development recapitulates characteristic features of Huntington’s disease (2016)

Aldrin E Molero*, Eduardo E Arteaga-Bracho*, Christopher H Chen, Maria Gulinello, Michael L Winchester, Nandini Pichamoorthy, Solen Gokhan, Kamran Khodakhah, Mark F Mehler

PNAS

Other fun projects

Silk fibroin films facilitate single-step targeted expression of optogenetic proteins (2018)

Skyler L Jackman*, Christopher H Chen*, Selmaan N Chettih, Shay Q Neufeld, Iain R Drew, Chimuanya K Agba, Isabella Flaquer, Alexis N Stefano, Thomas J Kennedy, Justine E Belinsky, Keiramarie Roberston, Celia C Beron, Bernardo L Sabatini, Christopher D Harvey, Wade G Regehr