|Cheng Dong, Ph.D.
Distinguished Professor of Biomedical Engineering
Department of Biomedical Engineering
205 Hallowell Building
The Pennsylvania State University
University Park, PA 16802-6804
Tel: (814) 865-8091
Fax: (814) 863-0490
Biomechanics. Cellular engineering and cell mechanics. Cellular behavior and mechanism in response to physical and chemical stimulation, with focuses on the inflammatory process, cancer immunoeditting and metastasis. Engineering applications to cell and molecular biology, including cell deformation, cell-cell adhesion, cell signaling, cell migration and motility.
In particular, he is investigating how fluid dynamics, adhesion kinetics and tumor microenvironment change leukocyte and/or endothelial immune functions which subsequently affect tumor cell extravasation in the microcirculation and subsequent metastasis. More recent research also involves immune cell-mediated smart drug delivery through the blood-brain barrier using programmable nanoparticles to brain tumors.
Fellow – American Institute for Medical and Biological Engineering (AIMBE).
Fellow – The Biomedical Engineering Society (BMES).
Member – The United States National Committee on Biomechanics (USNCB).
Member – The American Association for Cancer Research (AACR)
Member – The American Physiological Society (APS).
Guest Co-Editor (2009) – BMES Cellular and Molecular Bioengineering (Special Issue).
Managing Editor (2003 – present) – Frontiers in Bioscience.
Associate Editor (2009 – 2015) – BMES Annuals of Biomedical Engineering
Associate Editor (2007 – present) – BMES Journal of Cellular and Molecular Bioengineering.
Associate Editor (2006 – present)– Editorial Board for Journal of Molecular and Cellular Biomechanics.
Board Member (2002 – present) – Editorial Board for Journal of Medical Biomechanics (China).
Current Group Members
|Gloria Kim – Gloria graduated from Carnegie Mellon University with BS and MS degrees in Chemical Engineering. Prior to attending PSU, she worked as a process development engineer in antibody drug development at Johnson & Johnson. She joined the Cellular Biomechanics Lab in 2014 to pursue her Ph.D and is co-advised by Prof.Cheng Dong and Prof. Jian Yang. Her research focuses on drug delivery to brain tumors in this lab.
M.S Chemical Engineering – Carnegie Mellon University
|Byron Gaskin –|
|Virginia Aragon Sanabria – My main project focuses on elucidating the mechanisms for tumor cell extravasation using melanoma cells as a model. Our goal is to understand the main signaling pathways that tumor cells use for driving endothelial cell junction disassembly and contractility, which allows tumor cells to cross the microvascular endothelial cell barrier, enter the blood stream and metastasize to different organs in the body. Given the dynamic nature of this process and the number of signaling proteins involved, we integrate a modeling component that allows us to visualize protein concentration as well as protein activity changes along the process to better characterize tumor cell extravasation.
M.S Biochemistry and Molecular Biology (2010) – Georgetown University
|Xiaomeng Tang – (Dept of Material Science and Engineering) I’m currently a third-year graduate student majoring in chemistry. We are now studying the cellular uptake of calcium phosphosilicate nanoparticles (CPSNPs) encapsulated with fluorophore (Rhodamine WT) and/or anticancer drug (Docetaxel) by breast cancer cells (MDA-MB-231 cell line). The CPSNPs are prepared with double reverse micelle method and laundered by van der Waals-high performance liquid chromatography. Our goal of collaboration is to evaluate and improve the cellular uptake efficiency of encapsulated CPSNPs, which are a promising platform for both cancer diagnosis and treatment.|
|Nmachi Chinenye Anumba|
|Vikram Eswar – I am currently a third year student in the Schreyer Honors College majoring in biomedical engineering with a biochemical option. I am involved in studying the mechanisms of cancer cell adhesion and extravasation in human pulmonary microvascular endothelial cells. I joined Dr. Dong’s lab in the fall of 2014 due to my interest in cell signaling and tumor cell behaviors.|
|Virginia Gonzalez – I am currently a junior in the Schreyer Honors College majoring in Biomedical Engineering (Material Science option). My Honors thesis research focuses on nano-particle mediated drug delivery to circulating breast cancer cells, in collaboration between Dr. Dong’s lab in Biomedical Engineering and Dr. Adair’s lab in Material Science and Engineering. We found anti-tumor maker conjugated calcium phosphosilicated nanoparticles (CPNP) have the potential to encapsulate chemotherapeutic drugs and reach cancerous cells protecting the body from toxic side effects. My work will find how effectively we can deliver these CPNPs to targeted circulating tumor cells.|
Photos from previous years
NCI at the National Institutes of Health
|| Postdoctoral Fellow
Shanghai Jiao Tung University
Loyola Marymount University
||RES & DEV ENGR,
Penn State Applied Research Laboratory
||Manager, Scientific Affairs
Research and Development
Abbott Molecular, Inc.
Des Plaines, IL
Center for Molecular and Clinical
Chang Gung University,
Pennsylvania State University
Albert Eistein College of Medicine
Department of Anatomy & Structural Biology
||Sharon Lei Assistant Professor of Systematic Theology
Logos Evangelical Seminary
Hershey Medical Center- PSU
Musculoskeletal Research Lab
||Senior Principal Scientist
||Penn State College of Medicine||M.S. 2015|
||Cornell University||M.S. 2013|
||BioMagnetic Soluation, LLC in State College, PA||M.S. 2012|
||Medical school student
West Virginia School of Osteopathic Medicine
University of Delaware
||Kensey Nash||M.S. 2010|
|Rank, Brad||Wyeth||M.S. 1999|
||11 years with Merck and Co. Inc in various roles of vaccine production.||M.S. 1996|
|Hughes, Kelly (2013)
med student at VCU School of Medicine
|Johnstone, Jenna (2013)
|Behr, Julie (2012)
|Harter, Lauren (2012)
Perelman School of Medicine MD program, University of Pennsylvania
|Weidert, Eric (2011)
West Virginia School of Osteopathic Medicine (WVSOM)
|Knupp, Sarah (2011)
|Godiska, Lisa (2010)
|Goodrich, Chris (2010)
|Yunkunis, Tara (2009)
Biomaterials Engineering, DSM Biomedical
|Groleau, Patricia (2008)|
|Neville, Desiree (2006)
|Fire, Joe (2000)|
|Hann, Matthew (1999)|
|Barraco, Jennifer (1999)|
|Barnes, Ashley (1998)|
|Shung, Simon (1997)|
|Sourwine, Maraileen (1997)|
|Scarbourgh, Gary (1996)
|Gross, Chris (1996)