Selected Publications

  • Hedong Li and Gong Chen. (2016) In Vivo Reprogramming for CNS Repair: Regenerating Neurons from Endogenous Glial Cells. Neuron, 91:728-738. (Invited Review)
  • Xin Tang, Julie Kim, Li Zhou, Eric Wengert, Lei Zhang, Zheng Wu, Cassiano Carromeu, Alysson R. Muotri, Maria C. N. Marchetto, Fred H. Gage, and Gong Chen.  (2016)  KCC2 rescues functional deficits in human neurons derived from patients with Rett syndrome.   Proc Natl Acad Sci USA. Epub: 2016 Jan 5. News press:  http://news.psu.edu/story/386151/2016/01/04/research/discovery-new-drug-target-could-lead-novel-treatment-severe-autism
  • Gong ChenIn Vivo Reprogramming for Brain and Spinal Cord Repair. eNeuro 2(5) e0106-15.2015. (Review article).
  • Wu Z; Foster AC; Staubli U; Wu X; Sun C; Tang X; Li YX; Chen G.   (2015)   Effects of 3-aminoglutarate, a “silent” false transmitter for glutamate neurons, on synaptic transmission and epileptiform activity.   Neuropharmacology.  2015; 97:95-103.
  • Lei Zhang, Jiuchao Yin, Hana Yeh, Ningxin Ma, Grace Lee, Gangyi Wu, Gong Chen, Small molecules efficiently reprogram human astroglial cells into functional neurons. Cell stem cell. E-Pub on 2015 Oct.            News press: http://science.psu.edu/news-and-events
  • Ziyuan Guo, Lei Zhang, Zheng Wu, Yuchen Chen, Fan Wang, and Gong Chen. (2014) In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model. Cell Stem Cell, 14: 188-202. E-pub on Dec. 19, 2013. Read Nature Research Highlight…News press: http://medicalxpress.com/news/2013-12-brain-injury-alzheimer-disease.html
  • Zheng Wu, Ziyuan Guo, Marla Gearing, Gong Chen. (2014) Tonic inhibition in dentate gyrus impairs long-term potentiation and memory in an Alzheimer’s disease model. Nature Communications, June 13, 2014. Read This…                                                                              News press: http://medicalxpress.com/news/2014-06-alzheimer-memory-deficit-excessive-inhibition.html
  • Zhexing Wen*, Ha Nam Nguyen*, Ziyuan Guo*, Matthew Lalli, Xinyuan Wang, Yijing Su, Nam-Shik Kim, Ki-Jun Yoon, Jaehoon Shin, Ce Zhang, Georgia Makri, David Nauen, Humei Yu, Cheng-Hsuan Chiang, Nadine Yoritomo, Kozo Kaibuchi, Christopher Ross, Jizhong Zou, Kimberly Christian, Linzhao Cheng, Russell Magolis,Gong Chen, Kenneth Kosik, Elmer Guzman, Hongjun Song, and Guo-li Ming. Synaptic dysregulation in a human iPS cell model of mental disorders. Nature, E-pub Aug. 17, 2014. Read This…News press: http://neurosciencenews.com/synaptic-growth-disc1-neurodevelopment-1224/ 
  • Xin Tang, Li Zhou, Alecia M. Wagner, Maria C.N. Marchetto, Alysson R. Muotri, Fred H. Gage, and Gong Chen. (2013) Astroglial cells regulate the developmental timeline of human neurons differentiated from induced pluripotent stem cells. Stem Cell Research, E-pub May 16. Read This…News press: http://medicalxpress.com/news/2013-06-alzheimer-schizophrenia-autism-mature-brain.html
  • Chicheng Sun, Lei Zhang, and Gong Chen. (2013)  An unexpected role of neuroligin-2 in regulating KCC2 and GABA functional switch. Mol Brain, 6:23. Read This…
  • Xia Wu, Lanting Huang, Zheng Wu, Ce Zhang, Dongyun Jiang, Yuting Bai, Yun Wang, and Gong Chen. (2013) Homeostatic competition between phasic and tonic inhibition. J. Biol. Chem. First Published on July 9, 2013. Read This…
  • Yajie Sun, Zheng Wu, Shuzhen Kong, Dongyun Jiang, Anar Pitre, Yun Wang, and Gong Chen. (2013)  Regulation of epileptiform activity by two distinct subtypes of extrasynaptic GABAA receptors. Mol Brain, 6:21. Read This…
  • Wang R, McGrath BC, Kopp RF, Roe MW, Tang X, Chen G, Cavener DR. (2013) Insulin secretion and Ca2+ dynamics in β-cells are regulated by PERK eIF2α kinase in concert with calcineurin. J Biol Chem, 2013 Nov 22; 288(47):33824-36. Read This…
  • A. Alachkar, D. Jiang, M. Harrison, Y. Zhou, G. Chen, and Y. Mao.  (2013)   An EJC Factor RBM8a Regulates Anxiety Behaviors.  Current Molecular Medicine 2013, 13, 1-13. Read This…
  • Wu X, Wu Z, Ning G, Guo Y, Ali R, Macdonald RL, De Blas AL, Luscher B, Chen G. (2012) gamma-Aminobutyric Acid Type A (GABAA)  Receptor Alpha Subunits Play a Direct Role in Synaptic versus Extrasynaptic Targeting. J Biol Chem.  287(33): p. 27417-27430. Read This… News press:  http://www.sciencedaily.com/releases/2012/08/120808093854.htm
  • Joseph Cichon, Chi-Cheng Sun, Ben Chen, Min Jiang, Xiangyun Amy Chen, Yajie Sun, Yun Wang, and Gong Chen. (2012) Cofilin Aggregation Blocks Intracellular Trafficking and Induces Synaptic Loss. J Biol Chem.  287(6): 3919–3929. Read This… 
  • Brennand, K., A. Simone, J. Jou, C. Gelboin-Burkhart, N. Tran, S. Sangar, Y. Li, Y. Mu, G. Chen, D. Yu, S. McCarthy, J. Sebat, and F. Gage. (2011)  Modeling schizophrenia using human induced pluripotent stem cells. Nature 473: 221-225.  Read This…
  • Sun, C., M.-C. Cheng, R. Qin, D.L. Liao, T.-T. Chen, F.-J. Koong, G. Chen, and C.-H. Chen. (2011)  Identification and functional characterization of rare mutations of the neuroligin-2 gene (NLGN2) associated with schizophrenia. Human Molecular Genetics, 20(15): 3042–3051. Read This…
  • Fan, Y., X. Tang, E. Vitriol, G. Chen, and J. Q. Zheng. (2011)  Actin capping protein is required for dendritic spine development and synapse formation. Journal of Neuroscience 31(28): 10228-10233.
  • Yazhou Sun, Yaqiong Wang, Yi Hu, Gong Chen, Hong Ma.  (2011).   Comparative analysis of neural transcriptomes and functional implication of unannotated intronic expression.  BMC Genomics, 2011 Oct 10;12:494.
  • Marchetto, M. C. N., C. Carromeu, A. Acab, D. Yu, G. Yeo, Y. Mu, G. Chen, F. H. Gage, and A. R. Muotri.  (2010)  A model for neural development and treatment of Rett Syndrome using human induced pluripotent stem cells. Cell 143: 527-539. Read This…
  • Gu, J., C. W. Lee, Y. Fan, D. Komlos, X. Tang, C. Sun, K. Yu, H. C. Hartzell, G. Chen, J. R. Bamburg, and J. Q. Zheng.  (2010)  ADF/cofilin-mediated actin dynamics regulate AMPA receptor trafficking during synaptic plasticity. Nature Neuroscience 13: 1208-1215.  Read This…
  • Kong S, Qian B, Liu J, Fan M, Chen G, Wang Y. (2010) Cyclothiazide induces seizure behavior in freely moving rats. Brain Res. 1355:207-213.
  • Han, X. W., X. Wu, W. Y. Chung, T. Li, A. Nekrutenko, N. S. Altman, G. Chen*, and H. Ma*.  (2009)  Transcriptome of embryonic and neonatal mouse cortex by high-throughput RNA sequencing. Proc.Nat. Acad. Sci. USA 106: 12741-12746. Read This…
  • Jiang, M. and G. Chen.   (2009)   Ca2+ regulation of dynamin-independent endocytosis in cortical astrocytes. Journal of Neuroscience 29: 8063-8074. Read This…
  • Wang, Y., J. S. Qi, S. Kong, Y. Sun, J. Fan, M. Jiang, and G. Chen.   (2009)   BDNF-TrkB signaling pathway mediates the induction of epileptiform activity induced by a convulsant drug cyclothiazide. Neuropharmacology 57: 49-59.
  • Yuan, X., J. Yao, D. Norris, D. D. Tran, R. J. Bram, G. Chen, and B. Luscher.   (2008)   Calcium-modulating cyclophilin ligand regulates membrane trafficking of postsynaptic GABA(A) receptors. Mol. Cell Neurosci. 38(2): 277-289.
  • Deng, L., J. Yao, C. Fang, N. Dong, B. Luscher, and G. Chen.   (2007)  Sequential postsynaptic maturation governs the temporal order of GABAergic and glutamatergic synaptogenesis in rat embryonic cultures. Journal of Neuroscience 27(40): 10860-10869.  Read This…
  • Dong, N., Qi, J., Chen, G. (2007). Molecular reconstitution of functional GABAergic synapses with expression of neuroligin-2 and GABAA receptors. Mol. Cell. Neurosci. 35: 14 – 23. Read This…
  • Wendou Yu, Min Jiang, Celia P. Miralles, Gong Chen and Angel L. de Blas.  (2007). Gephyrin clustering is required for the stability of GABAergic synapses. Mol. Cell. Neurosci. 36(4):484-500.
  • Fang, C., Deng, L., Keller, C., Fukata, M., Fukata, Y., Chen, G., and Lüscher, B.   (2006). GODZ-mediated palmitoylation of GABAA receptors is required for normal assembly and function of GABAergic inhibitory synapses. Journal of Neuroscience, 26(49): 12758-12768 .
  • Qi, J. S., Yao, J., Fang, C., Lüscher, B., and Chen, G.  (2006).  Downregulation of tonic GABA currents following epileptogenic stimulation of rat hippocampal cultures. Journal of Physiology 577(2): 579-590. Read This…
  • Yao, J., Qi, J. S., and Chen, G.  (2006).  Actin-dependent activation of presynaptic silent synapses contributes to long-term synaptic plasticity in developing hippocampal neurons. Journal of Neuroscience, 26 (31): 8137 – 8147. Read This…   
  • Jiang, M. and Chen, G.   (2006).   High Ca2+-phosphate transfection efficiency in low-density neuronal cultures.  Nature Protocols. Vol. 1. (No. 2) 695 – 700. Read This…
  • Qi, J.S., Wang, Y., Jiang M., Warren, W., and Chen, G.  (2006). Cyclothiazide induces robust epileptiform activity in rat hippocampal neurons both in vitro and in vivo. Journal of Physiology  571(3): 605-618.
  • Zhou, J., Pfaff, D. W., and Chen, G. (2005). Sex differences in estrogenic regulation of neuronal activity in neonatal cultures of ventromedial nucleus of the hypothalamus. PNAS 102: 14907-14912.
  • Alldred, M.J., Mulder-Rosi, J., Lingenfelter, S. E., Chen, G., and Lüscher, B.  (2005) Distinct g2 Subunit Domains Mediate Clustering and Synaptic Function of Postsynaptic GABAA Receptors and Gephyrin. Journal of Neuroscience 25(3): 594-603.
  • Jiang, M., Deng, L.B., and Chen, G.   (2004).  High Ca2+-phosphate transfection efficiency enables single neuron gene analysis.  Gene Therapy  11:1303-1311.
  • Cao, Y-Q., Piedras-Renteria, E., Smith, G. B., Chen, G., Harata, N. C., Tsien, R. W.   (2004). Presynaptic Ca2+channels compete for channel type-preferring slots in altered neurotransmission arising from Ca2+channelopathy. Neuron 43: 387-400. Read This… 
  • Chen, G., Harata, N. and Tsien, R. W.  (2004). Paired-pulse depression of unitary quantal amplitude at single hippocampal synapses. PNAS 101: 1063-1068. Read This…
  • Deng, L. B., and Chen, G. (2003). Cyclothiazide potently inhibits g-aminobutyric acid type A receptors in addition to enhancing glutamate responses. PNAS 100 (22): 13025-13029. Read This…
  • Chen, Y., Deng, L. B., Maeno-Hikichi, Y., Lai, M. Z., Chang, S. H., Chen, G., and Zhang, J. F. (2003). Formation of an endophilin-Ca2+ channel complex is critical for clathrin-mediated synaptic vesicle endocytosis. Cell 115: 37-48.  Read This…