Solid-state nanopores have been extensively studied in the past decade due to their mechanical robustness, tunable size, thermal robustness, and integration potential. The solid-state nanopore family includes membrane materials such as SiNx, graphene, glass nanopores (nanopipette), and polymer nanopores. We study solid-state nanopores with the aim to understand the device physics, to explore viable fabrication and integration methods, and to develop single molecule sensing applications.
Fabrication
- M. Dong, Z. Tang, X. He, and W. Guan. Direct Observation of Redox-Induced Bubble Generation and Nanopore Formation Dynamics in Controlled Dielectric Breakdown. ACS Applied Electronic Materials, 2, 2954 (2020).
- X. He, Z. Tang, S. Liang, M. Liu, and W. Guan. Confocal Scanning Photoluminescence for Mapping Electron and Photon Beam Induced Microscopic Changes in SiNx during Nanopore Fabrication. Nanotechnology, 31, 395202 (2020).
- K. Roshan, Z. Tang, and W. Guan. High fidelity moving Z-Score based controlled breakdown fabrication of solid-state nanopore. Nanotechnology, 30, 095502 (2019).
Physics
- S. Liang, F. Xiang, Z. Tang, R. Nouri, X. He, M. Dong, and W. Guan, Noise in Nanopore Sensors: Sources, Models, Reduction And Benchmarking. Nanotechnology and Precision Engineering, 3, 9 (2020).
- R. Nouri, Z. Tang, and W. Guan. Calibration-Free Nanopore Digital Counting of Single Molecules. Analytical Chemistry, 91, 11178 (2019).
- R. Nouri, Z. Tang, and W. Guan. Quantitative Analysis of Factors Affecting the Event Rate in Glass Nanopore Sensors, ACS Sensors, 4, 3007 (2019).
Applications
- R. Nouri, Y. Jiang, X.X. Lian, and W. Guan. Sequence-Specific Recognition of HIV-1 DNA with Solid-State CRISPR-Cas12a-Assisted Nanopores (SCAN). ACS Sensors, 5, 1273 (2020).
- Z. Tang, G. Choi, R. Nouri, and W. Guan. Loop-Mediated Isothermal Amplification-Coupled Glass Nanopore Counting Towards Sensitive and Specific Nucleic Acid Testing. Nano Letters, 19, 7927 (2019).