We develop technologies to precisely control, manipulate fluids that are geometrically constrained to a small scale (from μL to fL). It involves multidisciplinary fields across engineering, physics, chemistry, and nanotechnology. It has practical applications in the design of systems that process low volumes of fluids to achieve multiplexing, automation, and high-throughput screening.

• G. Choi, R. Nouri, L. Zarzar, and W. Guan. Microfluidic Deformability-Activated Sorting of Single Particles. Microsystems and Nanoengineering, 6, 11 (2020).
• G. Choi, E. Murphy, and W. Guan. Microfluidic Time-Division Multiplexing Accessing Resistive Pulse Sensor for Particle Analysis. ACS Sensors, 4, 1957 (2019).
• X. Yang, Z.Chen, J. Miao, L. Cui, and W. Guan. High-throughput and label-free parasitemia quantification and stage differentiation for malaria-infected red blood cells. Biosensors and Bioelectronics, 98, 408 (2017).
• W. Guan, L. Chen, T. D. Rane, T.-H. Wang. Droplet Digital Enzyme-Linked Oligonucleotide Hybridization Assay for Absolute RNA Quantification. Scientific Reports, 5, 13795 (2015)