Publications

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Research Articles

* Corresponding author(s)

1. Yang, Y., Shin, Y. K., Ooe, H., Hasegawa, U., Yamane, S., Yamada, H., van Duin, A., Murase, Y., Mauro, J.* (2024) Adsorption of CO2 by Amine-functionalized Metal-Organic Frameworks Using GCMC and ReaxFF-based Metadynamics Simulations. The Journal of Physical Chemistry C: Energy, Materials, and Catalysis, 128, 12, 5257–5270. https://pubs.acs.org/doi/10.1021/acs.jpcc.3c07183.
2. Chang, R., Han, B., Ben Mabrouk, A. & Hasegawa, U.* (2024) Controlled Dissociation of Polymeric Micelles in Response to Oxidative Stress. Biomacromolecules, 25(2), 1162–1170. https://pubs.acs.org/doi/full/10.1021/acs.biomac.3c01156.
3. Young, K., Yamane S., GharehTapeh, E.A., Kasamatsu, S., Ihara, H. & Hasegawa, U.* (2024) Manganese porphyrin-containing polymeric micelles: A novel approach for intracellular catalytic formation of per/polysulfide species from a hydrogen sulfide donor. Advanced Healthcare Materials, 13(4), 2302429. https://doi.org/10.1002/adhm.202302429. Selected as a cover image.
4. van der Vlies, A.J., Yamane, S. & Hasegawa, U.* (2024) Recent Advance in Self-Assembled Polymeric Nanomedicines for Gaseous Signaling Transmitter Delivery. WIREs Nanomedicine & Nanobiotechnology, 16(1), e1934. https://doi.org/10.1002/wnan.1934.
5. Madbouly, S.*, Yamane, S., van der Vlies, A.J. & Hasegawa, U. (2023) Bio-based semi-interpenetrating polymer networks of poly(ε-caprolactone) (PCL) and epoxidized soybean oil (ESO) with nanoscale morphology, shape-memory effect, and biocompatibility. ACS Applied Polymer Materials, 5(11), 8907-8918. https://doi.org/10.1021/acsapm.3c01270.
6. van der Vlies, A.J. & Hasegawa, U.* (2023) Functionalization of Framboidal Phenylboronic Acid-Containing Nanoparticles via Aqueous Suzuki-Miyaura Coupling Reactions. Molecules, 28(8), 3602. https://doi.org/10.3390/molecules28083602. Selected as a Feature Paper.
7. van der Vlies, A.J., Ghasemi, M., Adair, B.M., Adair, J.H., Gomez, E.D., Hasegawa, U.* (2023) Reactive Oxygen Species-Triggered Hydrogen Sulfide Release and Cancer-Selective Antiproliferative Effect of Anethole Dithiolethione-Containing Polymeric Micelles. Advanced Healthcare Materials, 12 (6), 2201836. https://doi.org/10.1002/adhm.202201836. Selected as a cover image.
8. Hasegawa, U.* (2023) Polymeric Biomaterials for Delivery of the Gasotransmitter Hydrogen Sulfide. Journal of Japanese Society for Biomaterials,  41(2), 118-120 https://kokuhoken.net/jsbm/public/journal.html.
9. Yuge, S.*, Nishiyama, K., Arima ,Y., Hanada, Y., Oguri-Nakamura, E., Hanada, S., Ishii, T., Wakayama, Y., Hasegawa, U., Tsujita, K., Yokokawa, R., Miura, T., Itoh, T., Tsujita, K., Mochizuki, N., Fukuhara, S.* (2022) Mechanical loading of intraluminal pressure mediates wound angiogenesis by regulating the TOCA family of F-BAR proteins. Nature Communications, 13(1), 2594. https://doi.org/10.1038/s41467-022-30197-8
10. van der Vlies, A.J., Xu, J., Ghasemi, M., Bator, C., Bell, A., Rosoff-Verbit, B., Liu, B., Gomez, E.D., & Hasegawa, U.* (2022) Thioether-Based Polymeric Micelles with Fine-Tuned Oxidation Sensitivities for Chemotherapeutic Drug Delivery. Biomacromolecules, 23 (1), 77-88. https://doi.org/10.1021/acs.biomac.1c01010. Selected as a cover image.
11. Chen, J. J. Y., Van der Vlies, A. J., & Hasegawa, U.* (2020). Hydrogen sulfide-releasing micelles for promoting angiogenesis. Polymer Chemistry, 11(27), 4454-4463. https://doi.org/10.1039/D0PY00495B. Featured by Polymer Chemistry Blog “Polymer Chemistry Author of the Month.” 
12. van der Vlies, A. J.†, Morisaki, M.†, Neng, H. I., Hansen, E. M., & Hasegawa, U.* (2019). Framboidal nanoparticles containing a curcumin-phenylboronic acid complex with antiangiogenic and anticancer activities. Bioconjugate Chemistry, 30(3), 861-870. https://doi.org/10.1021/acs.bioconjchem.9b00006. Selected as a cover image. † Both authors contributed equally.
13. Taba, F., Onoda, A.*, Hasegawa, U., Enoki, T., Ooyama, Y., Ohshita, J., & Hayashi, T.* (2018). Mitochondrial-targeting polyamine−protoporphyrin conjugates for photodynamic therapy. ChemMedChem, 13(1), 15-19. https://doi.org/10.1002/cmdc.201700467. Selected as a cover image.
14. Takatani-Nakase, T.*,  Katayama, M., Matsui, C.,  Hanaoka, K., van der Vlies, A. J., Takahashi, K., Nakase, I.*, & Hasegawa, U.* (2017). Hydrogen sulfide donor micelles protect cardiomyocytes from ischemic cell death. Molecular BioSystems, 13(9), 1705-1708. https://doi.org/10.1039/C7MB00191F. Selected as a cover image.
15. van der Vlies, A. J., Inubushi, R., Uyama, H., & Hasegawa, U.* (2016). Polymeric framboidal nanoparticles loaded with a carbon monoxide donor via phenylboronic acid-catechol complexation. Bioconjugate Chemistry, 27(6), 1500-1508. https://doi.org/10.1021/acs.bioconjchem.6b00135. Selected as a cover image.
16. Hasegawa, U.*, Wang, T., Chen, J. J. Y., Uyama, H., & van der Vlies, A. J. (2016). Furoxan-bearing micelles for nitric oxide delivery. Macromolecular Bioscience, 16(7), 1009-1018. https://doi.org/10.1002/mabi.201500401. Selected as a cover image.
17. Hasegawa, U.*, Wang, T., Uyama, H., & van der Vlies, A. J. (2016).  Copper removal from polymers by diethyldithiocarbamate complexation. Chemistry Letters, 45(4), 400-402. https://doi.org/10.1246/cl.151120.
18. Xin, Y., Sakamoto, J., Van der Vlies, A. J., Hasegawa, U., & Uyama, H.* (2016). Data in support of preparation and functionalization of a clickable polycarbonate monolith. Data in Brief, 7, 183-187. https://doi.org/10.1016/j.dib.2016.02.020
19. Hasegawa, U.*, Inubushi, R., Uyama, H., Uematsu, T., Kuwabata, S., & van der Vlies, A. J. (2015). Mannose-displaying fluorescent framboidal nanoparticles containing phenylboronic acid groups as a potential drug carrier for macrophage targeting. Colloids and Surfaces B: Biointerfaces, 136, 1174-1181. https://doi.org/10.1016/j.colsurfb.2015.11.011
20. Wang, T., Van der Vlies, A. J., Uyama, H., & Hasegawa, U.* (2015). Nitric oxide-releasing polymeric furoxan conjugates. Polymer Chemistry, 6(44), 7737 – 7748. https://doi.org/10.1039/C5PY01335F
21. Hasegawa, U.*, Nishida, T., & van der Vlies, A. J. (2015). Dual stimuli-responsive phenylboronic acid-containing framboidal nanoparticles by one-step aqueous dispersion polymerization. Macromolecules, 48(13), 4388-4393. https://doi.org/10.1021/acs.macromol.5b00574
22. Hasegawa, U.*, Tateishi, N., Uyama, H., & van der Vlies, A. J. (2015). Hydrolysis-sensitive dithiolethione prodrug micelles. Macromolecular Bioscience, 15(11), 1512-1522. https://doi.org/10.1002/mabi.201500156. Featured by Materials Views, “An Old Drug in a New Form: Dithiolethione Prodrug Micelles”. Selected as a cover image.
23. Hasegawa, U.*, Moriyama, M., Metzger, S., van der Vlies, A. J., Uyama, H., & Ehrbar, M. (2015). Catechol-bearing polymeric nanoparticles for antioxidant therapy. MRS Proceedings, 1797, mrss15-2132870.https://doi.org/10.1557/opl.2015.506.
24. Hasegawa, U.*, Moriyama, M., Uyama, H., & van der Vlies, A. J. (2015). Catechol-bearing block copolymer micelles: Structural characterization and antioxidant activity. Polymer, 66, 1-7. https://doi.org/10.1016/j.polymer.2015.03.080
25. Hasegawa, U.*, Moriyama, M., Uyama, H., & van der Vlies, A. J. (2015). NMR spectra and electrochemical behavior of catechol-bearing block copolymer micelles. Data in Brief, 4, 1-6. https://doi.org/10.1016/j.dib.2015.04.004
26. Xin, Y., Sakamoto, J., van der Vlies, A. J., Hasegawa, U., & Uyama, H.* (2015). Phase separation approach to a reactive polycarbonate monolith for “click” modifications. Polymer, 66, 52-57. https://doi.org/10.1016/j.polymer.2015.04.008
27. Hasegawa, U.*, Moriyama, M., Uyama, H., & van der Vlies, A. J. (2015). Antioxidant micelles for bortezomib delivery. Colloid and Polymer Science, 293(7), 1887-1892. https://doi.org/10.1007/s00396-015-3582-z
28. Moriyama, M., Uyama, H., van der Vlies, A. J., & Hasegawa, U.* (2015). Cross-linked catechol-bearing poly(γ-glutamic acid) self-aggregates with antioxidant activity. Colloid and Polymer Science, 293(4), 1245-1251. https://doi.org/10.1007/s00396-015-3516-9
29. Hasegawa, U.*, & van der Vlies, A. J. (2015). Polymeric micelles for hydrogen sulfide delivery. Medicinal Chemistry Communications, 6(2), 273-276. https://doi.org/10.1039/C4MD00373J. Selected as one of the most-read articles published in 2015.
30. Moriyama, M., Metzger, S., van der Vlies, A. J., Uyama, H., Ehrbar, M., &  Hasegawa, U.* (2015). Inhibition of angiogenesis by antioxidant micelles. Advanced Healthcare Materials, 4(4), 569-575. https://doi.org/10.1002/adhm.201400249. Selected as a cover image.
31. Han, W., Yamauchi, M., Hasegawa, U., Noda, M., Fukui, K., van der Vlies, A. J., Uchiyama, S., & Uyama, H.* (2015). Pepsin immobilization on an aldehyde-modified polymethacrylate monolith and its application for protein analysis. Journal of Bioscience and Bioengineering, 119(5), 505-510. https://doi.org/10.1016/j.jbiosc.2014.10.018
32. Park, S. B., Hasegawa, U., van der Vlies, A. J., Sung, M. H., & Uyama, H.* (2014). Preparation of poly(γ-glutamic acid)/hydroxyapatite monolith via biomineralization for bone tissue engineering. Journal of Biomaterials Science: Polymer Edition, 25(17), 1875-90. https://doi.org/10.1080/09205063.2014.953404
33. Hasegawa, U.*, & van der Vlies, A. J. (2014). Design and synthesis of polymeric hydrogen sulfide donors. Bioconjugate Chemistry, 25(7), 1290-1300. https://doi.org/10.1021/bc500150s. Featured by Global Medical Discovery as one of the Key Scientific Articles.
34. Han, W., Xin, Y., Hasegawa, U., & Uyama, H.* (2014). Enzyme immobilization on polymethacrylate-based monolith fabricated via thermally induced phase separation. Polymer Degradation and Stability, 109, 362-366. https://doi.org/10.1016/j.polymdegradstab.2014.05.032
35. Yoneda, S., Han, W., Hasegawa, U., & Uyama, H.* (2014). Facile fabrication of poly(methyl methacrylate) monolith via thermally induced phase separation by utilizing unique cosolvency. Polymer, 55(15), 3212-3216. https://doi.org/10.1016/j.polymer.2014.05.031
36. van der Vlies, A. J., Han, W., Uyama, H., & Hasegawa, U.* (2014). Dextran acetate-based sponge as cell scaffold for tissue engineering. Journal of Biomaterials and Tissue Engineering, 4(1), 28-36. https://doi.org/10.1166/jbt.2014.1135
37. Hasegawa, U., van der Vlies, A. J., Wandrey, C., & Hubbell, J. A.* (2013). Preparation of well-defined ibuprofen prodrug micelles by RAFT polymerization. Biomacromolecules, 14(9), 3314-3320. https://doi.org/10.1021/bm4009149
38. van der Vlies, A. J., & Hasegawa, U.* (2013). P51 Polymeric micelles for controlled delivery of hydrogen sulfide. Nitric Oxide, 31(2), S58. https://doi.org/10.1016/j.niox.2013.06.113
39. van der Vlies, A. J., Hasegawa, U., Hubbell, J. A.* (2012). Reduction-sensitive tioguanine prodrug micelles. Molecular Pharmaceutics, 9(10), 2812-2818. https://doi.org/10.1021/mp3001183
40. Wandrey, C., Hasegawa, U., van der Vlies, A. J., O’Neil, C., Angelova, N., & Hubbell, J. A.* (2011). Analytical ultracentrifugation to support the development of biomaterials and biomedical devices. Methods, 54(1), 92-100. https://doi.org/10.1016/j.ymeth.2010.12.003
41. Hasegawa, U., van der Vlies, A. J., Simeoni, E., Wandrey, C., & Hubbell, J. A.* (2010). Carbon monoxide-releasing micelles for immunotherapy. Journal of the American Chemical Society, 132(51), 18273–18280. https://doi.org/10.1021/ja1075025
42. van der Vlies, A. J., O’Neil, C.P., Hasegawa, U., Hammond, N., & Hubbell, J. A.* (2010). Synthesis of pyridyl disulfide-functionalized nanoparticles for conjugating thiol-containing small molecules, peptides, and proteins. Bioconjugate Chemistry, 21(4), 653-662. https://doi.org/10.1021/bc9004443
43. Inomoto, N., Osaka, N., Suzuki, T., Hasegawa, U., Ozawa, Y., Endo, H., Akiyoshi, K., & Shibayama, M.* (2009). Interaction of nanogel with cyclodextrin or protein: Study by dynamic light scattering and small-angle neutron scattering. Polymer, 50(2), 541-546. https://doi.org/10.1016/j.polymer.2008.11.001
44. Miyai, K., Yoneda, M., Hasegawa, U., Toita, S., Izu, Y., Hemmi, H., Hayata, T., Ezura, Y., Mizutani, S., Miyazono, K., Akiyoshi, K., Yamamoto, T., & Noda*, M. (2009). ANA deficiency enhances bone morphogenetic protein-induced ectopic bone formation via transcriptional events. The Journal of Biological Chemistry, 284(16), 10593-10600. https://doi.org/10.1074/jbc.M807677200
45. Hayashi, C., Hasegawa, U., Saita, Y., Hemmi, H., Hayata, T., Nakashima, K., Ezura, Y., Amagasa, T., Akiyoshi, K., & Noda, M.* (2009). Osteoblastic Bone Formation Is Induced by Using Nanogel-Crosslinking Hydrogel as Novel Scaffold for Bone Growth Factor. Journal of Cellular Physiology, 220(1), 1-7. https://doi.org/10.1002/jcp.21760
46. Hasegawa, U., Sawada, S., Shimizu, T., Kishida, T., Otsuji, E., Mazda, O., & Akiyoshi, K.* (2009). Raspberry-like assembly of cross-linked nanogels for protein delivery. Journal of Controlled Release, 140(3), 312-317. https://doi.org/10.1016/j.jconrel.2009.06.025
47. Shimizu, T., Kishida, T., Hasegawa, U., Ueda, Y., Imanishi, J., Yamagishi, H., Akiyoshi, K., Otsuji, E. & Mazda*, O. (2008). Nanogel DDS enables sustained release of IL-12 for tumor immunotherapy. Biochemical and Biophysical Research Communications, 367(2), 330-335. https://doi.org/10.1016/j.bbrc.2007.12.112
48. Toita, S., Hasegawa, U., Koga, H., Sekiya, I., Muneta, T., & Akiyoshi*, K. (2008). Protein-conjugated quantum dots effectively delivered into living cells by a cationic nanogel. Journal of Nanoscience and Nanotechnology, 8(5), 2279-2285. https://doi.org/10.1166/jnn.2008.240
49. Alles, N., Soysa, N.S., Mian, A., Tomamatsu, N., Morimoto, N., Hasegawa, U., Sawada, S., Tada, Y., Akiyoshi, K., Ohya, K., & Aoki, K.* (2008). Nanogel Cross-linking Hydrogel as a Drug Delivery System for Tumor Necrosis Factor-alpha Antagonist. Journal of Bone and Mineral Research, 23, S403-S403.
50. Kato, N.†, Hasegawa, U.†, Morimoto, N., Saita, Y., Nakashima, K., Ezura, Y., Kurosawa, H., Akiyosh, K.*, & Noda, M.* (2007). Nanogel-based delivery system enhances PGE(2) effects on bone formation. Journal of Cellular Biochemistry, 101(5), 1063-1070. https://doi.org/10.1002/jcb.21160. † Both authors contributed equally.
51. Fukui, T., Kobayashi, H., Hasegawa, U., Nagasawa, T., Akiyoshi, K., & Ishikawa, I.* (2007). Intracellular delivery of nanogel-quantum dot hybrid nanoparticles into human periodontal ligament cells. Drug Metabolism Letters, 1(2), 131-135. https://doi.org/10.2174/187231207780363570
52. Alles, C. N. R., Morimoto, N., Hasegawa, U., Mian, A., Soysa, N. S., Saito, H., Aoki, K., Baron, R., Akiyoshi, K., & Ohya, K.* (2006). Subcutaneous injection of W9 peptide and CHP nanogel complex inhibits the decrease of BMD induced by a low Ca feeding in mice. Journal of Bone and Mineral Research, 21, S396-S396.
53. Nagase, K., Hasegawa, U., Kohori, F., Sakai, K.*, & Nishide, H. The photoresponse of a molybdenum porphyrin makes an artificial gill feasible. (2005). Journal of Membrane Science, 249(1-2), 235-243. https://doi.org/10.1016/j.memsci.2004.10.040
54. Hasegawa, U., Nomura, S. I. M., Kaul, S.C., Hirano, T., & Akiyoshi, K.* (2005). Nanogel-quantum dot hybrid nanoparticles for live cell imaging. Biochemical and Biophysical Research Communications, 331(4), 917-921. https://doi.org/10.1016/j.bbrc.2005.03.228
55. Aoyagi, S., Hayama, M., Hasegawa, U., Sakai, K., Tozu, M., Hoshi, T., & Kudo, M.* (2004). Estimation of protein adsorption on dialysis membrane by means of TOF-SIMS imaging. Journal of Membrane Science, 236(1-2), 91-99. https://doi.org/10.1016/j.memsci.2004.02.010
56. Aoyagi, S., Hayama, M., Hasegawa, U., Sakai, K., Hoshi, T., & Kudo, M.* (2004). TOF-SIMS imaging of protein adsorption on dialysis membrane. Applied Surface Science, 231-2, 411-415. https://doi.org/10.1016/j.apsusc.2004.03.149
57. Aoyagi, S., Hayama, M., Hasegawa, U., Sakai, K., Hoshi, T., & Kudo, M.* (2003). TOF-SIMS imaging of protein adsorption on dialysis membrane by means of information entropy. e-Journal of Surface Science and Nanotechnology, 1, 67-71. https://doi.org/10.1380/ejssnt.2003.67

Books

1. Hasegawa, U., & Akiyoshi, K. (2007). Drug delivery systems by nanogel engineering. Saibo Kogaku, 26(6), 679-685.
2. Hasegawa, U., & Akiyoshi, K. (2005). Nanogel carriers, soft-Nanotechnology: The biomaterial revolution (pp. 236-244). CMC Publishing.
3. Morimoto, N., Hasegawa, U., Sugawara, A., Yamane, S., & Akiyoshi, K. (2006). In H. Yuasa (Ed.), Nanotechnology in Carbohydrate Chemistry (pp. 67-85). Transworld Research Network.

Patent

1. Akiyoshi, K., Hirano, T., & Hasegawa, U. (2006). Quantum dot-nanogel composites with improved colloidal stability, their preparation, control of quantum dot dissociation from them, and control of uptake rate of them into animal cells. Kokai Tokkyo Koho, JP 2006143808 A 20060608.