01/30/2019: Article on human DNA damage tolerance from the Hedglin Lab published in JBC

DNA damage tolerance permits bypass of DNA lesions encountered during S-phase and may be carried out by translesion DNA synthesis (TLS). Human TLS requires selective monoubiquitination of proliferating cell nuclear antigen (PCNA) sliding clamps encircling damaged DNA.  This posttranslational modification (PTM) is catalyzed by Rad6/Rad18. Recent studies revealed that replication protein A (RPA), the major ssDNA-binding… Read More 01/30/2019: Article on human DNA damage tolerance from the Hedglin Lab published in JBC

December 17, 2018: Weide Xiao joins the Hedglin Lab

Weide Xiao, a 1st year graduate student pursuing a PhD in chemistry, joined the Hedglin Lab.  Weide received his B.S. in Biology from Peking University in China where he also performed research in the lab of Dr. Chengqi Yi.  Weide’s undergraduate research focused on the repair of oxidative DNA damage in humans.  In the Hedglin lab, Weide’s graduate… Read More December 17, 2018: Weide Xiao joins the Hedglin Lab