PARP2 is a DNA-dependent ADP-ribosyl transferase (ARTs) enzyme with Poly(ADP-ribosyl)ation activity that is triggered by DNA breaks. It plays a role in the Base Excision Repair pathway, where it has overlapping functions with PARP1. However, additional roles for PARP2 have emerged in the response of cells to replication stress. In this study, we demonstrate that… Read More 04/02/2024: Fouquerel lab, in collaboration with the Hedglin Lab, Publish a Manuscript on Break Induced Replication-mediated Telomere Fragility

Fragile sites are unstable genomic regions that are prone to breakage during stressed DNA replication. Several common fragile sites (CFS) contain A+T-rich regions including perfect [AT/TA] microsatellite repeats that may collapse into hairpins when in single-stranded DNA (ssDNA) form and coincide with chromosomal hotspots for breakage and rearrangements. While many factors contribute to CFS instability,… Read More 03/27/2024: The Hedglin Lab, in Collaboration with the Eckert Lab, Publish a Manuscript on the Replication of Human Microsatellite Repeat Sequences

Grace Young (2nd Year, Chemistry PhD student) was named a recipient of a 2023 Chemistry Graduate Student Teaching Award, in recognition of her superior dedication and ability in fulfilling her instructional responsibilities.

Kara Pytko, a 5th year Chemistry PhD student in the Hedglin, was awarded a Harry and Catharine Dalalian Graduate Fellowship in Organic Chemistry from the Eberly College of Science at The Pennsylvania State University. This fellowship award is given to graduate students in recognition of their research accomplishments, publications, and seminar presentations.

Dr. Hedglin and Rachel Dannenberg (4th year Chemistry PhD student) attended the 2024 GRS/GRC: DNA Damage, Mutation, and Cancer in Ventura, California to present research projects from the Hedglin Lab. During the GRS and GRC portions of the conference, Rachel presented recent findings on one of her thesis projects (Translesion DNA Synthesis by Human DNA… Read More 03/10/2024: Hedglin Lab Members Present Their Research at the 2024 GRS/GRC: DNA Damage, Mutation, and Cancer

Dr. Hedglin visited Cornell University to present a seminar in the department of Molecular Biology & Genetics. He was invited & hosted by Dr. J. Brooks Crickard.

Dr. Hedglin visited the department of Chemistry at the University of California-Riverside to present a seminar on the research going on in the Hedglin Lab. He was invited & hosted by Dr. Linlin Zhou.

Two new members joined the Hedglin Lab in the Spring 2024 semester. Tyler Wenzel is a first year graduate student in the Molecular, Cellular, and Integrative Biosciences (MCIBS) Graduate Program. Tyler received a B.S. in Biology from Marist College. Jonathan Weinstein is a first year undergraduate student with an intent to major in Chemistry. Jonathan… Read More 01/08/2024: Two New Members Join the Hedglin Lab

Dr. Hedglin visited the University of Michigan Medical School to present a seminar in the Department of Biological Chemistry. He was hosted by Dr. Patrick J. O’Brien, PhD (Professor, Biological Chemistry, Associate Chair, Biological Chemistry).

Dr. Hedglin visits the University of Iowa Carver College of Medicine to present a seminar in the department of Biochemistry & Molecular Biology. He was hosted by Dr. M. Todd Washington (Professor, Biochemistry and Molecular Biology).   View from the “old” capital building             Children’s Hospital (right) overlooking Kinnick Football… Read More 11/16/2023: Dr. Hedglin Visits the University of Iowa Carver College of Medicine to Present a Seminar in the Department of Biochemistry & Molecular Biology