Publications

At PSU

  1. Shin, Y., Hedglin M., and Murakami, K.S. Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase. Nucleic Acids Research, 2020, gkz1221, https://doi.org/10.1093/nar/gkz1221

 

  1. Li M., Larsen L., and Hedglin, M. Rad6/Rad18 competes with DNA polymerases η and δ for PCNA encircling DNA. Biochemistry, 2019, Dec 30. doi: 10.1021/acs.biochem.9b00938. [Epub ahead of print]. https://pubs.acs.org/doi/10.1021/acs.biochem.9b00938

  1. *Hedglin, M., Aitha M., and Benkovic, S.J. Replication protein A dynamically regulates monoubiquitination of proliferating cell nuclear antigen. J Biol Chem, 2019, 294, 5157-5168. http://www.jbc.org/content/294/13/5157.long

         * = Corresponding Author

Before PSU:

  1. Hedglin, M., Aitha M., and Benkovic, S.J. Monitoring the Retention of Human PCNA at Primer/Template junctions by Proteins that Bind Single-stranded DNA. Biochemistry, 2017, 56, 3415 – 3421. https://pubs.acs.org/doi/10.1021/acs.biochem.7b00386

         

  1. Hedglin, M. and Benkovic, S.J. Eukaryotic Translesion DNA Synthesis on the Leading and Lagging Strands: Unique Detours Around the Same Obstacle. 2017, ACS Chemical Reviews, 117, 7857 – 7877. https://pubs.acs.org/doi/10.1021/acs.chemrev.7b00046

  1. Hedglin, M. and Benkovic, S.J. Replication protein A prohibits diffusion of the PCNA sliding clamp along single-stranded DNA. Biochemistry, 2017, 56, 1824 – 1835. https://pubs.acs.org/doi/10.1021/acs.biochem.6b01213

  1. Hedglin, M., Pandey, B., and Benkovic, S.J. Characterization of human translesion DNA synthesis across a UV-induced DNA lesion. 2016, eLife 5, e19788. https://elifesciences.org/articles/19788
  1. Hedglin, M., Pandey, P., and Benkovic, S.J. Stability of the human polymerase δ holoenzyme and its implications in lagging strand DNA synthesis. 2016, Proc Natl Acad Sci U S A, 113, E1777 – E1786. https://www.pnas.org/content/113/13/E1777.long

 

  1. Hedglin, M., Zhang, Y., and O’Brien, P.J. Probing the DNA structural requirements for facilitated diffusion. Biochemistry, 2015, 54, 557-566. https://pubs.acs.org/doi/10.1021/bi5013707

 

  1. Hedglin, M., and Benkovic, S.J. Regulation of Rad6/Rad18 Activity During DNA Damage Tolerance. Annu Rev Biophys, 2015, 44, 207-228. https://www.annualreviews.org/doi/full/10.1146/annurev-biophys-060414-033841?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed

 

  1. Hedglin, M., Zhang, Y., and O’Brien, P.J. Isolating contributions from intersegmental transfer to DNA searching by alkyladenine DNA glycosylase. J Biol Chem, 2013, 288, 24550-24559. http://www.jbc.org/content/288/34/24550.long
  1. Hedglin, M., Perumal, S.K., Hu, Z., and Benkovic, S. Stepwise assembly of the human replicative polymerase holoenzyme. eLife, 2013, 2, e00278. https://elifesciences.org/articles/00278

 

  1. Hedglin, M., Kumar, R., and Benkovic, S.J. Replication clamps and clamp loaders. Cold Spring Harb Perspect Biol, 2013, 5, a010165. https://cshperspectives.cshlp.org/content/5/4/a010165.long

 

  1. Hedglin, M., and O’Brien, P.J. Hopping enables a DNA repair glycosylase to search both strands and bypass a bound protein. ACS Chem Biol, 2010, 5, 427-436. https://pubs.acs.org/doi/abs/10.1021/cb1000185

  1. Hedglin, M., and O’Brien, P.J. Human alkyladenine DNA glycosylase employs a processive search for DNA damage. Biochemistry, 2008, 47, 11434-11445. https://pubs.acs.org/doi/10.1021/bi801046y

  1. Krennhrubec, K., Marshall, B.L., Hedglin, M., Verdin, E., and Ulrich, S.M. Design and evaluation of ‘Linkerless’ hydroxamic acids as selective HDAC8 inhibitors. Bioorg Med Chem Lett, 2007, 17, 2874-2878. https://www.sciencedirect.com/science/article/pii/S0960894X07002612?via%3Dihub