Publications

At PSU

  1. *Hedglin, M., Aitha M., and Benkovic, S.J. Replication protein A dynamically regulates monoubiquitination of proliferating cell nuclear antigen. The Journal of Biological Chemistry, 2019, Papers in Press, 01/30/2019. http://www.jbc.org/content/early/2019/01/30/jbc.RA118.005297.long

         * = Corresponding Author

Before PSU:

  1. Hedglin, M., Aitha M., and Benkovic, S.J. Monitoring the Retention of Human PCNA at Primer/Template junctions by Proteins that Bind Single-stranded DNA. Biochemistry, 2017, 56, 3415 – 3421. https://pubs.acs.org/doi/10.1021/acs.biochem.7b00386

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  1. Hedglin, M. and Benkovic, S.J. Eukaryotic Translesion DNA Synthesis on the Leading and Lagging Strands: Unique Detours Around the Same Obstacle. 2017, ACS Chemical Reviews, 117, 7857 – 7877. https://pubs.acs.org/doi/10.1021/acs.chemrev.7b00046

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  1. Hedglin, M. and Benkovic, S.J. Replication protein A prohibits diffusion of the PCNA sliding clamp along single-stranded DNA. Biochemistry, 2017, 56, 1824 – 1835. https://pubs.acs.org/doi/10.1021/acs.biochem.6b01213

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  1. Hedglin, M., Pandey, B., and Benkovic, S.J. Characterization of human translesion DNA synthesis across a UV-induced DNA lesion. 2016, eLife 5, e19788. https://elifesciences.org/articles/19788
  1. Hedglin, M., Pandey, P., and Benkovic, S.J. Stability of the human polymerase δ holoenzyme and its implications in lagging strand DNA synthesis. 2016, Proc Natl Acad Sci U S A, 113, E1777 – E1786. https://www.pnas.org/content/113/13/E1777.long

 

  1. Hedglin, M., Zhang, Y., and O’Brien, P.J. Probing the DNA structural requirements for facilitated diffusion. Biochemistry, 2015, 54, 557-566. https://pubs.acs.org/doi/10.1021/bi5013707

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  1. Hedglin, M., and Benkovic, S.J. Regulation of Rad6/Rad18 Activity During DNA Damage Tolerance. Annu Rev Biophys, 2015, 44, 207-228. https://www.annualreviews.org/doi/full/10.1146/annurev-biophys-060414-033841?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed

 

  1. Hedglin, M., Zhang, Y., and O’Brien, P.J. Isolating contributions from intersegmental transfer to DNA searching by alkyladenine DNA glycosylase. J Biol Chem, 2013, 288, 24550-24559. http://www.jbc.org/content/288/34/24550.long
  1. Hedglin, M., Perumal, S.K., Hu, Z., and Benkovic, S. Stepwise assembly of the human replicative polymerase holoenzyme. eLife, 2013, 2, e00278. https://elifesciences.org/articles/00278

 

  1. Hedglin, M., Kumar, R., and Benkovic, S.J. Replication clamps and clamp loaders. Cold Spring Harb Perspect Biol, 2013, 5, a010165. https://cshperspectives.cshlp.org/content/5/4/a010165.long

 

  1. Hedglin, M., and O’Brien, P.J. Hopping enables a DNA repair glycosylase to search both strands and bypass a bound protein. ACS Chem Biol, 2010, 5, 427-436. https://pubs.acs.org/doi/abs/10.1021/cb1000185

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  1. Hedglin, M., and O’Brien, P.J. Human alkyladenine DNA glycosylase employs a processive search for DNA damage. Biochemistry, 2008, 47, 11434-11445. https://pubs.acs.org/doi/abs/10.1021/bi801046y

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  1. Krennhrubec, K., Marshall, B.L., Hedglin, M., Verdin, E., and Ulrich, S.M. Design and evaluation of ‘Linkerless’ hydroxamic acids as selective HDAC8 inhibitors. Bioorg Med Chem Lett, 2007, 17, 2874-2878. https://www.sciencedirect.com/science/article/pii/S0960894X07002612?via%3Dihub