Publications

Family Matters. Mark L. Mayer, Timothy Jegla. (2018)  ElifeDec 28;7. pii: e43815. doi: 10.7554/eLife.43815. http://www.plantcell.org/content/early/2018/11/01/tpc.18.00523.long

The S6 gate in regulatory Kv6 subunits restricts heteromeric K+ channel stoichiometry. Aditya Pisupati, Keith J. Mickolajczyk, William Horton, Damian B. van Rossum, Andriy Anishkin, Sree V. Chintapalli, Xiaofan Li, Jose Chu-Luo, Gregory Busey, William O. Hancock, and Timothy Jegla. (2018) J Gen Physiol, Dec 3;150(12):1702-1721. doi: 10.1085/jgp.201812121.  http://www.plantcell.org/content/early/2018/11/01/tpc.18.00523.long

Evolution and structural Chracteristics of Plant Voltage-Gated K+ Channels. Timothy Jegla, Gregory Busey, and Sally M. Assmann. (2018) Plant Cell, Nov 1pii: tpc.00523.2018. http://www.plantcell.org/content/early/2018/11/01/tpc.18.00523.long

Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment.. Timothy Jegla, Michelle M. Nguyen, Chengye Feng, Daniel J. Goetschius, Esteban Luna, Damian B. van Possum, Bishoy Kamel, Aditya Pusuati, Elliot S. Milner, and Melissa M. Rolls. (2016) PLoS Genetics, Dec 2;12(12):e1006457.
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006457#abstract0

Nicotinamide (vitamin B3) activates invertebrate TRPV sensory channels. Awani Upadhyay,   Aditya Pisupati, Timothy Jegla, Matt Crook, Keith J. Mickolajczyk, Matthew Shorey, Laura E. Rohan, Katherine A. Billings, Mellisa M. Rolls, William O. Hancock, and Wendy Hanna-Rose. (2016) Nature Communications, Oct 12; 7, 13135. http://www.nature.com/articles/ncomms13135

Guard cell sensory systems: recent insights on stomatal responses to light, abscisic acid, and CO2. Sarah M. Assmann and Timothy Jegla. (2016) Current Opinion in Plant Biology, October 2016, Pages 157–167. http://www.sciencedirect.com/science/article/pii/S1369526616301066

Functional Charaterization of Cnidarian HCN Chaneels Points to an Early Evolution of Ih. Emma C. Baker, Michael J. Layden, Damian B. van Rossum, Bishoy Kamel, Monica Medina, Eboni Simpson, and Timothy Jegla. (2015) PLoS One, Nov 10;10(11):e0142730. PMCID:PMC4640657.

Bimodal regulation of an Elk subfamily K+ channel by phosphatidylinositol 4,5-bisphosphate. Xiaofan Li, Andriy Anishkin, Hansi Liu, Damian B. van Rossum, Sree V. Chintapalli, Jessica K. Sassic, David Gallegos, Kendra Pivaroff-Ward, and Timothy Jegla. (2015) Journal of General Physiology, 146(5):357-374. PMCID:PMC4621751.

A major diversification of voltage-gated K+ channels occurred in ancestral parahoxozoans. Xiaofan Li, Hansi Liu, Jose Chu Luo, Sarah A. Rhodes, Liana M. Trigg, Damian B. van Rossum, Andriy Anishkin, Fortunay H. Diatta, Jessica K. Sassic, David K. Simmons, Bishoy Kamel, Monica Medina, Mark Q. Martindale, and Timothy Jegla (2015) Proc Natl Acad Sci USA, Mar 3;112(9):E1010-9.PMCID:PMC4352839.

Ether-a-go-go family Voltage-Gated K+ Channels evolved in an ancestral metazoan and functionally diversified in a Cnidarian/Bilaterian Ancestor. Li X., Martinson A.S., Layden M.J., Diatta F.H., Sberna A.P., Simmons D.K., Martindale M.Q., Jegla T. (2015) J Exp Biol, Feb 15;218(Pt 4):526-36 .PMCID:PMC4334144.

Neuronal polarity: an evolutionary perspective. Melissa M. Rolls and Timothy J. Jegla (2015) J Exp Biol., Feb 15;218(Pt 4):572-80. PMCID:PMC4334146.

Functional evolution of Erg potassium channel gating reveals an ancient origin for IKr. Martinson A.S., van Rossum D.B., Diatta F.H., Layden M.J., Rhodes S.A., Martindale M.Q., Jegla T. (2014) Proc Natl Acad Sci USA. 15;111(15):5712-7. PMCID:PMC3992637.

External pH modulates EAG superfamily K+ channels through EAG-specific acidic residues in the voltage sensor. Kazmierczak M, Zhang X, Chen B, Mulkey DK, Shi Y, Wagner PG, Pivaroff-Ward K, Sassic JK, Bayliss DA, Jegla T (2013) 2013. J Gen Physiol. Jun; 141(6):721-35. PMCID: PMC3664700.

Expanded functional diversity of Shaker K+ channels in cnidarians is driven by gene expansion. Jegla T, Marlow HQ, Chen B, Simmons DK, Jacobo SM, Martindale MQ. (2012) PLoS One. 2012;7(12):e51366. PMCID: PMC3519636.

Asymmetric divergence in structure and function of HCN channel duplicates in Ciona intestinalis. Jackson HA, Hegle A, Nazzari H, Jegla T, Accili EA. (2012) PLoS One. 2012;7(11):e47590. doi: 10.1371/journal.pone.0047590. PMCID:PMC3487815.

Spiroindolones, a potent compound class for the treatment of malaria. Rottmann M, McNamara C, Yeung BK, Lee MC, Zou B, Russell B, Seitz P, Plouffe DM, Dharia NV, Tan J, Cohen SB, Spencer KR, González-Páez GE, Lakshminarayana SB, Goh A, Suwanarusk R, Jegla T, Schmitt EK, Beck HP, Brun R, Nosten F, Renia L, Dartois V, Keller TH, Fidock DA, Winzeler EA, Diagana TT. (2010) Science. 2010 Sep 3;329(5996):1175-80. PMCID:PMC3050001.

Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy. Zhang X., Bertaso F., Yoo J., Baumgartel K., Clancy S.M., Lee V., Cienfuegos C., Wilmot C., Avis J., Huynh T., Daguia C., Schmedt C., Noebels J., Jegla T. (2010) Nat Neurosci. 2010 Sep;13(9):1056-8. PMCID:PMC2928878.

Divalent cations slow activation of EAG family K+ channels through direct binding to S4. Zhang, X., Bursulaya, B., Lee, C., Chen, B, Pivaroff, K., Jegla, T. (2009) Biophys J. Jul 8;97(1):110-20. PMCID:PMC2711382.

KCNE1 and KCNE3 b-subunits Regulate Membrane Surface Expression of Kv12.2 K+ Channels and form a Tripartite Complex in vivo. Clancy, S.M., Chen, B., Bertaso, F., Mamet, J., Jegla, T. (2009) PLoS One. Jul 22;4(7):e6330. PMCID:PMC2710002.

Evolution of the Human Ion Channel Set. Jegla, T., Zmasek, C., Batalov, S., Nayak, S.K. (2009) Combinatorial Chemistry & High Throughput Screening. Jan;12(1):2-23. PMID:19149488.

An internal thermal sensor controlling temperature preference in Drosophila. Hamada F.N., Rosenzweig M., Kang K., Pulver S.R., Ghezzi A., Jegla T.J. Garrity P.A. (2008) Nature. 10;454(7201):217-20.PMCID:PMC2730888.

Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels. Xiao B., Dubin A.E., Bursulaya B., Viswanath V., Jegla T.J., Patapoutian A. (2008) J Neurosci. 24;28(39):9640-51. PMCID:PMC2678945.

Inducible ablation of melanopsin-expressing retinal ganglion cells reveals their central role in non-image forming visual responses. Hatori M., Le H., Vollmers C., Keding S.R., Tanaka N., Schmedt C., Jegla T., Panda S. (2008) PLoS ONE. 11;3(6):e2451. PMCID:PMC2396502.

A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Petrus M., Peier A.M., Bandell M., Hwang S.W., Huynh T., Olney N., Jegla T., Patapoutian A. (2007) Mol Pain. 17;3:40.PMCID:PMC2222610.

Role of a novel photopigment, melanopsin, in behavioral adaptation to light. Nayak, S., Jegla, T., Panda, S. (2007). Cell Mol Life Sci. 64(2):144-54. PMID: 17160354.

Illumination of the melanopsin signaling pathway. Panda S., Nayak S., Campo B., Hogenesch J., Jegla, T. (2005) Science 307(5709):600-604. PMID:15681390.

ANKTM1, A TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Story G.M., Peier A.M., Reeve A.J., Eid S.R., Mosbacher J., Hricik T.R., Earley T.J., Hergarden A.C., Andersson D.A., Hwang S.W., McIntyre P., Jegla T., Bevan S., Patapoutian A. (2003) ANKTM1, Cell 112(6):819-29. PMID:12654248.

Opposite thermosensor in fruitfly and mouse. Viswanath V, Story GM, Peier AM, Petrus MJ, Lee VM, Hwang SW, Patapoutian A, Jegla T. (2003) Nature. 2003 Jun 19;423(6942):822-3. PMID:12815418.

Analysis of the mouse transcriptome for genes involved in the function of the nervous system. Gustincich S, Batalov S, Beisel KW, Bono H, Carninci P, Fletcher CF, Grimmond S, Hirokawa N, Jarvis ED, Jegla T, Kawasawa Y, LeMieux J, Miki H, Raviola E, Teasdale RD, Tominaga N, Yagi K, Zimmer A, Hayashizaki Y, Okazaki Y; RIKEN GER Group; GSL Members. (2003) Genome Res. Jun;13(6B):1395-401. PMCID:PMC403671.

Distribution and functional properties of human KCNH8 (Elk1) potassium channels. Zou A, Lin Z, Humble M, Creech CD, Wagoner PK, Krafte D, Jegla TJ, Wickenden AD. (2003) Am J Physiol Cell Physiol. 285(6):C1356-66. PMID:12890647.

Characterization of KCNQ5/Q3 potassium  channels expressed in mammalian cells. Wickenden A.D., Zou A., Wagoner P.K., Jegla T. (2001) British Journal of Pharmacology 132(2):381-4. PMCID:PMC1572592.

Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4. Brenner R., Jegla T.J., Wickenden A., Liu Y., Aldrich R.W. (2000) Journal of Biological Chemistry 275(9):6453-61. PMID:10692449.

Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels. Wickenden A.D., Yu W., Zou A., Jegla T., Wagoner P.K. (2000) Molecular Pharmacology 58(3):591-600. PMID: 10953053.

Regional contributions of Kv1.4, Kv4.2, and Kv4.3 to transient outward K+ current in rat ventricle. Wickenden A.D., Jegla T.J., Kaprielian R., Backx P.H. (1999) American Journal of Physiology 276(5 Pt 2):H1599-607. PMID:10330244.

A novel subunit for shal K+ channels radically alters activation and inactivation. Jegla T., Salkoff L. (1997) Journal of Neuroscience 1 17(1):32-44. PMID:8987734.

Eight potassium channel families revealed by the C. elegans genome project. Wei A., Jegla T., Salkoff L. (1996) Neuropharmacology 35(7):805-29. PMID:8938713.

Surfing the DNA databases for K+ channels nets yet more diversity. Salkoff L., Jegla T. (1995) Neuron 15(3):489-92. PMID:7546728.

Multiple Shaker potassium channels in a primitive metazoan. Jegla T., Grigoriev N., Gallin W.J., Salkoff L., Spencer A.N. (1995) Journal of Neuroscience 15(12):7989-99. PMID:8613736.

A multigene family of novel K+ channels from Paramecium tetraurelia. Jegla T., Salkoff L. (1995) Receptors Channels 3(1):51-60. PMID:8589993.

Molecular evolution of K+ channels in primitive eukaryotes. Jegla T., Salkoff L. (1994) Society of General Physiology Serial (Molecular Evolution of Physiological Processes) 49:213-22. PMID:7939896.