Jose Laboratory

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Funding

Current funding
1R01AI176505-01A1 Mechanisms of tunneling nanotube formation by ZIKV NS1 in viral host interactions at the maternal-fetal interface. MPI Joyce Jose (contact), MPI Indira Mysorekar.
1R01AI168169-01A1 Defining the molecular interactions required for flavivirus genome packaging and virus assembly. (PI: Joyce Jose)
1R21AI178533-01 Intracellular functions and mechanisms of alphavirus ion channel 6K (PI: Joyce Jose)
Identifying flavivirus determinants of entry and replication as potential vaccine candidates. (PI: Joyce Jose)
Collaborations
1R01AI177352-01 Exploring the coevolutionary potential of chikungunya virus and its Aedes mosquito vectors (PI: Elizabeth McGraw, Co-I Jason Rasgon, Co-I Joyce Jose)
Completed support
COVID-19 Seed Grant. Targeted therapeutic intervention strategies against SARS-CoV-2.
Lab bench to commercialization Seed grant. Develop cell-based inducible fluorescent localization assay systems for antiviral screening of protease inhibitors against zoonotic, positive-strand RNA viruses with outbreak potential.
Discovering how RNA epigenomic modifications impact flavivirus replication speed and fidelity. (PI: Joyce Jose)
Understanding viral factors responsible for vector adaptation and spillover for surveillance and mitigation of zoonotic flaviviruses with pandemic potential. (PI: Joyce Jose)
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