Publications and Patents


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Google Scholar Citation Index: Lee J. Silverberg

Research Gate: https://www.researchgate.net/profile/Lee_Silverberg/projects

Researchers at Penn State: https://pennstate.pure.elsevier.com/en/persons/lee-jonathan-silverberg/publications/

I am guest editing a special issue of Molecules: “Synthetic Studies Aimed at Heterocyclic Organic Compounds, 2nd Edition.” Submissions are open. https://www.mdpi.com/journal/molecules/special_issues/B149EBQUI6

REFEREED PUBLICATIONS:

59. H. P. Yennawar, T. Mal, M. A. Olsen, A. F. Lagalante, E. M. Louca,* A. D. Gavalis,* L. J. Silverberg, “Synthesis and Crystal Structures of Two Racemic Heteroaryl-substituted-2,3-dihydro-4H-pyrido[3,2-e][1,3]thiazin-4-ones,” Acta Cryst. Sect. E: Crystallographic Commun. 2024, 80, 699-703. (open access)  https://journals.iucr.org/e/issues/2024/07/00/tx2086/index.html

58. H. P. Yennawar, M. W. Russell, L. J. Silverberg, “6,7-Diphenyl-5-thia-7-azaspiro[2.6]nonan-8-one 5,5-dioxide,” IUCrData., 2023, 8, Article x230937 (open access). https://iucrdata.iucr.org/x/issues/2023/10/00/hb4455/index.html

57. L. J. Silverberg, T. Mal, C. N. Pacheco, H. P. Yennawar, A. F. Lagalante, M. A. Olsen, M. W. Russell, E. N. Yeagley, E. L. Ziegler, “Novel Conversion of 2,3-Diaryl-2,3-dihydro-4H-1,3-thiaza-4-ones to Dimeric Ring-opened Thioacetals,” Results in Chemistry. 2023, 6, Article 101062. (open access) https://www.sciencedirect.com/science/article/pii/S2211715623003016   Featured in The ISHC Bulletin Aug. 2023, 80, 1. https://ishc.wp.st-andrews.ac.uk/files/2023/09/Aug-2023.pdf

56. H. P. Yennawar, T. K. Mal, C. N. Pacheco, A. F. Lagalante, M. A. Olsen, M. W. Russell, G. C. Muench, Q. J. Moyer, L. J. Silverberg,   “Crystal Structures of the Sulfones of 2,3-Diphenyl-2,3-dihydro-4H-1,3-benzothiazin-4-one and 2,3-Diphenyl-2,3-dihydro-4H-pyrido[3,2-e][1,3]thiazin-4-one,” Acta Cryst., Sect. E: Crystallographic Commun. 2023, 79, 221-225.  https://journals.iucr.org/e/issues/2023/03/00/hb8054/index.html

55. H. P. Yennawar, S. L. Lowe, M. M. Mammen, C. R. Verhagen, L. J. Silverberg, “Crystal structures of rac-2,3-diphenyl-2,3,5,6-tetrahydro-4H-1,3-thiazine-1,1,4-trione and N-[(2S,5R)-1,1,4-trioxo-2,3-diphenyl-1,3-thiazinan-5-yl]-acetamide,” Acta Cryst. Sect. E: Crystallographic Commun. 2023, 79, 120-123. (open access)  https://journals.iucr.org/e/issues/2023/02/00/hb8050/index.html

54. L. J. Silverberg, “Three-Part Approach to Remote/Residential Organic Chemistry Lab During the COVID-19 Pandemic,” J. Chem. Educ. 2021, 98, 3898-3903. https://pubs.acs.org/doi/full/10.1021/acs.jchemed.1c00900  Another awesome graphical abstract by my daughter Carrie!

53. H. P. Yennawar, J. J. Medica, L. J. Silverberg, “Synthesis and crystal structure of racemic (R*,R*)-2,2’-(1,4-phenylene)bis(3-phenyl-2,3,5,6-tetrahydro-4H-1,3-thiazin-4-one),” Acta Cryst. Sect. E: Crystallogr. Commun. 2021, 77, 1263-1266. (open access) https://scripts.iucr.org/cgi-bin/paper?S2056989021011592

52. L. J. Silverberg, T. K. Mal, C. N. Pacheco, M. L. Povelones, M. F. Malfara, A. F. Lagalante, M. A. Olsen, H. P. Yennawar, H. F. Sobhi, K. R. Baney, R. L. Bozeman, C. S. Eroh, M. J. Fleming, T. L. Garcia, C. L. Gregory, J. E. Hahn, A. M. Hatter, L. Johns, T. L. Klinger, J. Li, A. J. Menig, G. C. Muench, M. E. Ramirez, J. Reilly, N. Sacco, A. Sheidy, M. M. Stoner, E. N. Thompson, S. Yazdani, “T3P-Promoted Synthesis of a Series of 2-Aryl-3-phenyl-2,3-dihydro-4H-pyrido[3,2-e][1,3]thiazin-4-ones and Their Activity against the Kinetoplastid Parasite Trypanosoma brucei,” Molecules, 2021, 26, 6099. Part of special issue on “Organic Synthesis in Drug Discovery.” (open access) https://doi.org/10.3390/molecules26206099 Featured in The ISHC Bulletin Nov. 2021, 44, 5. https://ishc.wp.st-andrews.ac.uk/files/2021/11/2021-61-November.pdf

51. M. F. Malfara, L. J. Silverberg, J. DiMaio, A. F. Lagalante, M. A. Olsen, E. Madison, M. L. Povelones, “2,3-Diphenyl-2,3-dihydro-4H-1,3-thiaza-4-one heterocycles inhibit growth and block completion of cytokinesis in kinetoplastid parasites,” Molecular & Biochemical Parasitology, 2021, 245,111396. (open access) https://doi.org/10.1016/j.molbiopara.2021.111396

50. L. J. Silverberg, “What is an organic substance?” Foundations of Chemistry, 2021, 23, 329-336. https://doi.org/10.1007/s10698-021-09400-z  Full text here: https://rdcu.be/cizBs  Awesome graphical abstract by my daughter Carrie!

49. L. J. Silverberg, “The Pandemic Defeated My CURE: Replacement with a Student Project of a Literature Review of the Syntheses of Small Molecule Drugs,” J. Chem. Educ. 2020, 97, 3450-3454. https://pubs.acs.org/doi/full/10.1021/acs.jchemed.0c00555

48. L. J. Silverberg, C. Pacheco, D. Sahu, T. Mal, P. Scholl, H. F. Sobhi, H. G. Bradley, O. A. Cardenas, K. M. Gonzalez, J. M. Islam, E. G. Kimmel, W. Li, K. C. Perhonitch, J. T. Pothering, M. E. Potts, M. E. Ramirez, H. E. Reppert, K. N. Shaffer, “T3P-Promoted Synthesis of a Series of Novel 2-Aryl-3-phenyl-2,3,5,6-tetrahydro-4H-1,3-thiazin-4-ones,” Tetrahedron Lett. 2020, 61(18), Article 151836.  https://www.sciencedirect.com/science/article/pii/S0040403920302768?via%3Dihub Featured in The ISHC Bulletin June/July 2020 Part 1, 44, 2. http://ishc.wp.st-andrews.ac.uk/files/2020/07/2020-44-JuneJuly-Part-1.pdf

47. L. J. Silverberg, C. Pacheco, D. Sahu, P. Scholl, H. F. Sobhi, J. T. Bachert, K. Bandholz, R. V. Bendinsky, H. G. Bradley, B. K. Colburn, D. J. Coyle, J. R. Dahl, M. Felty, R. F. Fox, K. M. Gonzalez, J. M. Islam, S. E. Koperna, Q. J. Moyer, D. J. Noble, M. E. Ramirez, Z. Yang, “T3P-promoted synthesis of a series of novel 3-aryl-2-phenyl-2,3-dihydro-4H-1,3-benzothiazin-4-ones,” J. Heterocycl. Chem. 2020, 57, 797-1805.  https://onlinelibrary.wiley.com/doi/10.1002/jhet.3904   Featured in The ISHC Bulletin June/July 2020 Part 1, 44, 3.  http://ishc.wp.st-andrews.ac.uk/files/2020/07/2020-44-JuneJuly-Part-1.pdf46. H. P. Yennawar, J. Li, E. N. Thompson, L. J. Silverberg, “Crystal structures of two solvated 2-aryl-3-phenyl-2,3-di­hydro-4H-pyrido[3,2-e][1,3]thia­zin-4-ones,” Acta Cryst. Sect. E: Crystallographic Commun. 2019, E75, 1689-1693. (open access) https://journals.iucr.org/e/issues/2019/11/00/hb7856/index.html

45. H. P. Yennawar, S. D. Petersen, L. J. Silverberg, “Crystal structures of two isomeric 2-aryl-3-phenyl-1,3-thiazepan-4-ones,” Acta Cryst. Sect. E: Crystallographic Commun. 2019, E75, 1270-1273. (open access) http://scripts.iucr.org/cgi-bin/paper?S2056989019010429

44. L. J. Silverberg and Q. J. Moyer, “Chemistry of 1,3-thiazin-4-ones and their derivatives, 1995 – Mid 2018,” Arkivoc 2019, (i), 139-227. (open access)  https://www.arkat-usa.org/arkivoc-journal/browse-arkivoc/ark.5550190.p010.788  Featured in The ISHC Bulletin, August 2019, #34, 4. http://ishc.wp.st-andrews.ac.uk/files/2019/08/2019-34-August.pdf

43. L. J. Silverberg, “(R,R)- and (S,S)-Diphenylethylenediamine,” 1st Update, in Encyclopedia of Reagents for Organic Synthesis, John Wiley & Sons Ltd., 2019. https://onlinelibrary.wiley.com/doi/10.1002/047084289X.rn00098.pub2

42. H. P. Yennawar, L. J. Silverberg, K. C. Cannon, D. Gandla, S. K. Kondaveeti, M. J. Zdilla, and A. Nuriye, “Crystal structures of two 1,3-thiazolidin-4-one derivatives featuring sulfide and sulfone functional groups,” Acta Cryst. Sect. E: Crystallographic Commun. 2018, E74, 1695-1699. (open access) https://journals.iucr.org/e/issues/2018/12/00/hb7781/index.html

41.  H. P. Yennawar, Q. J. Moyer, and L. J. Silverberg, “Crystal structure of meso-3,3′-(1,4-phenylene)bis(2-phenyl-2,3,5,6-tetrahydro-4H-1,3-thiazin-4-one),” Acta Cryst. Sect. E: Crystallogr. Commun. 2018, E74, 1497-1499. (open access)   http://journals.iucr.org/e/issues/2018/10/00/hb7772/index.html

40. L. J. Silverberg, J. Tierney, and K. C. Cannon, “Embedded Research in a Lower-Division Organic Chemistry Lab Course,” in Best Practices for Supporting and Expanding Undergraduate Research in Chemistry, R. Jones, B. Gourley, Eds.; American Chemical Society Symposium Series eBooks, Washington, D. C., 2018, pp. 65-79. https://pubs.acs.org/isbn/9780841232846

39. H. P. Yennawar, H. G. Bradley, K. C. Perhonitch, H. E. Reppert, and L. J. Silverberg, “Spontaneous resolution and crystal structure of (2S)-2-(3-Nitrophenyl)-3-phenyl-2,3,5,6-tetrahydro-4H-1,3-thiazin-4-one; crystal structure of rac-2-(4-Nitrophenyl)-3-phenyl-2,3,5,6-tetrahydro-4H-1,3-thiazin-4-one,” Acta Cryst. Sect. E: Crystallographic Commun. 2018, E74, 454-457. (open access) http://journals.iucr.org/e/issues/2018/04/00/hb7733/index.html Chosen by the journal as a “highlighted article.” Also a “Selected Recent Crystallographic Paper” in Crystallography Times, 2018, 10(4). https://rigaku.com/resources/newsletters/crystallography-times


38. H. P. Yennawar, M. J. Buchwalter, B. K. Colburn, and L. J. Silverberg “Crystal structures of two 2,3-diaryl-2,3-dihydro-4H-1,3-benzothiazin-4-ones,” Acta Cryst. Sect. E: Crystallogr. Commun. 2018, E74, 363-366. (open access) http://journals.iucr.org/e/issues/2018/03/00/hb7726/index.html

37. H. P. Yennawar, J. Tierney, and L. J. Silverberg, “rac-cis-5-Methyl-2,3-diphenyl-1,3-thiazolidin-4-one,” IUCrData 2017, 2, x171662. (open access)  http://scripts.iucr.org/cgi-bin/paper?S2414314617016625   Chosen by the journal as a “highlighted article.”

36. H. P. Yennawar, D. J. Noble, and L. J. Silverberg, “Crystal Structure of (1S,2S,5R)-5-(acetylamino)-4-oxo-2,3-diphenyl-1,3-thiazinan-1-ium-1-olate,” Acta Cryst. Sect. E: Crystallogr. Commun. 2017, E73, 1417-1420. (open access) http://journals.iucr.org/e/issues/2017/10/00/zs2387/index.html

35. H. P. Yennawar, D. J. Noble. Z. Yang, and L. J. Silverberg, “rac-2,3-Diphenyl-2,3-dihydro-4H-pyrido[3,2-e][1,3]thiazin-4-one 1-oxide,” IUCrData 2017, 2, x171112.  (open access) http://iucrdata.iucr.org/x/issues/2017/08/00/su5380/index.html

34. H. P. Yennawar, R. F. Fox, Q. J. Moyer, Z. Yang, and L. J. Silverberg “Crystal structure of 2,3-Diphenyl-2,3-dihydro-4H-1,3-benzothiazin-4-one 1-oxide,” Acta Cryst. Sect. E: Crystallogr. Commun. 2017, E73, 1189-1191. (open access) https://doi.org/10.1107/S2056989017010313

33. L. J. Silverberg, J. Tierney, C. Pacheco, A. Lagalante, J. T. Bachert, J. A. Bayliff, R. V. Bendinsky, A. S. Cali, L. Chen, A. D. Cooper, M. J. Minehan, C. R. Mroz, D. J. Noble, A. K. Weisbeck, Y. Xie, and Z. Yang “Synthesis and spectroscopic properties of a series of novel 2-aryl-3-phenyl-2,3-dihydro-4H-1,3-benzothiazin-4-ones,” Arkivoc 2016, (vi), pp. 122-143. (open access) https://www.arkat-usa.org/arkivoc-journal/browse-arkivoc/ark.5550190.p009.875 Featured in The ISHC Bulletin April 2017, 11, 3. https://ishc.wp.st-andrews.ac.uk/files/2016/10/2017-11-April.pdf. Also featured in “Undergraduate Research Highlights” in SPUR: Scholarship and Practice of Undergraduate Research Fall 2017, 1 (1), 74-75. http://www.cur.org/publications/SPUR/

32. L. J. Silverberg, J. Tierney, and K. C. Cannon, “Research at Predominantly Two-Year Campuses of Penn State,” in The Power and Promise of Early Research, D. H. Murray, S. O. Obare, J. H. Hageman, Eds.; American Chemical Society Symposium Series eBooks, Washington, D. C., 2016, pp. 83-118.  http://pubs.acs.org/doi/abs/10.1021/bk-2016-1231.ch006 Ch. 12 has essays by two former students, Aaron Cali and Javon Rabb-Lynch. http://pubs.acs.org/doi/abs/10.1021/bk-2016-1231.ch012  Penn State News article about it: http://news.psu.edu/story/443566/2017/01/05/commonwealth-campus-professors-make-independent-chemical-research-part-class?utm_source=newswire&utm_medium=email&utm_term=444181_HTML&utm_content=01-10-2017-07-56&utm_campaign=schuylkill%20newswire

31. H. P. Yennawar, Z. Yang, and L. J. Silverberg, “Crystal structure of rac-2,3-diphenyl-2,3,5,6-tetrahydro-4H-1,3-thiazin-4-one 1-Oxide,” Acta Cryst. Sect. E: Crystallogr. Commun. 2016, E72, 1541-1543. (open access) http://scripts.iucr.org/cgi-bin/paper?S2056989016015395

oxide

30. H. P. Yennawar, D. J. Coyle., D. J. Noble, Z. Yang, and L. J. Silverberg, “Crystal structures of three 3-aryl-2-phenyl-2,3-dihydro-4H-1,3-benzothiazin-4-ones,” Acta Cryst., Sect. E: Crystallogr. Commun. 2016, E72, 1108-1112. (open access) http://scripts.iucr.org/cgi-bin/paper?S2056989016011002

29. L. J. Silverberg, D. J. Coyle, K. C. Cannon, R. T. Mathers, J. A. Richards, and J. Tierney, “Azeotropic Preparation of a C-Phenyl N-Aryl Imine: An Introductory Undergraduate Organic Chemistry Laboratory Experiment,” J. Chem. Educ. 2016, 93, 941-944. https://pubs.acs.org/doi/10.1021/acs.jchemed.6b00056

Abstract drawing

28. H. P. Yennawar, R. Fox, and L. J. Silverberg. “Crystal structure of the 1:1 adduct of 2,3-diphenyl-2,3,5,6-tetrahydro-4H-1,3-thiazin-4-one with triphenyltin chloride,” Acta Cryst. Sect. E: Crystallogr. Commun. 2016, E72, 276-279. (open access) http://journals.iucr.org/e/issues/2016/03/00/bg2579/index.html

27.  L. J. Silverberg, K. A. Kistler, K. A. Brobst, H. Yennawar, A. Lagalante, G. He, K. Ali, A. Blatt, S. B. Foster, D. B. Grossman, S. Hegel, M. J. Minehan, D. M. Valinsky, and J. G. Yeasted, “Reactions of the halonium ions of carenes and pinenes: An experimental and theoretical study,” Eur. J. Chem. 2015, 6, 430-443. (open access)  http://www.eurjchem.com/index.php/eurjchem/article/view/1307

abstract_graphic

26. L. J. Silverberg, C. N. Pacheco, A. Lagalante, K. C. Cannon, J. T. Bachert, Y. Xie, L. Baker, and J. A. Bayliff, “Synthesis and Spectroscopic Properties of 2,3-Diphenyl-1,3-thiaza-4-one Heterocycles,” Int. J. Chem. (Toronto, ON, Can.) 2015, 7(2), 150-162. (open access) http://www.ccsenet.org/journal/index.php/ijc/article/view/52881

bigger

25. K. Cannon, D. Gandla, S. Lauro, L. Silverberg, J. Tierney, and A. Lagalante, “Selective Synthesis of Ortho-substituted 3-Cyclohexyl-2-phenyl-1,3-thiazolidin-4-one Sulfoxides and Sulfones by S-Oxidation with Oxone,” Int. J. Chem. (Toronto, ON, Can.) 2015, 7(2), 73-84. (open access) http://www.ccsenet.org/journal/index.php/ijc/article/view/51529

cannon oxone paper

24. H. P. Yennawar, A. S. Cali, Y. Xie, and L. J. Silverberg, “Crystal sructures of 2-(4-nitrophenyl)-3-phenyl-2,3-dihydro-4H-1,3-benzothiazin-4-one and 2-(2-nitrophenyl)-3-phenyl-2,3-dihydro-4H-1,3-benzothiazin-4-one,” Acta Cryst. Sect. E: Crystallogr. Commun. 2015, E71, 414-417. (open access) http://dx.doi.org/10.1107/S2056989015004545

both structures

23.  H. P. Yennawar, P. D. Hullihen, J. Tierney, and L. J. Silverberg, “Crystal structures of 2,3-bis(p-chlorophenyl)-1,3-thiazolidin-4-one and trans-2,3-bis(p-chlorophenyl)-1,3-thiazolidin-4-one-1-oxide,” Acta Cryst. Sect. E: Crystallogr. Commun. 2015, E71, 264-267. (open access) doi:10.1107/S2056989015001954

p-chloros

22. L. J. Silverberg and L. M. Raff, “Are the Concepts of Dynamic Equilibrium and the Thermodynamic Criteria for Spontaneity, Nonspontaneity, and Equilibrium Compatible?” J. Chem. Educ. 2015, 92, 655-659. http://pubs.acs.org/doi/abs/10.1021/ed500660j eq and spon

21.  H. P. Yennawar, H. Singh, and L.  J. Silverberg, “Crystal structure of N-[(2S,5R)-4-oxo-2,3-diphenyl-1,3-thiazinan-5-yl]acetamide 0.375 hydrate,” Acta Cryst. Sect. E: Crystallogr. Commun. 2015, E71, 62-64. (open access)  doi:10.1107/S2056989014026425

cysteine thiazinone with water

20.  L. J. Silverberg, J. Tierney, and M. J. Bodek, “Use of Doceri Software for iPad in Online Delivery of Chemistry Content,” J. Chem. Educ. 2014, 91, 1999-2001. http://pubs.acs.org/doi/abs/10.1021/ed4009057

abstractgraphic3

19.  L. J. Silverberg, J. M. Rabb, J. M. Reno, and G. He, “Cyclopropyl aziridines: solvolytic reactions of the N-tosylaziridines of (+)-2-carene and (+)-3-carene,” Heterocycl. Commun. 2014, 20, 193-199. (open access) http://www.degruyter.com/view/j/hc.2014.20.issue-4/hc-2014-0093/hc-2014-0093.xml?format=INT

carene aziridine

18.  H. P. Yennawar, J. Tierney, and L. J. Silverberg, “2,3-Diphenyl-1,3-thiazolidin-4-one,” Acta Cryst. Sect. E: Struct. Rep. Online 2014, E70, o847. (open access) doi:10.1107/S1600536814015128

diphenylthiazolidinone

17.  H. P. Yennawar, H. Singh, and L. J. Silverberg, “2,3-Diphenyl-2,3-dihydro-4H-pyrido[3,2-e][1,3]thiazin-4-one,” Acta Cryst. Sect. E: Struct. Rep. Online 2014, E70, o638. (open access)  doi:10.1107/S1600536814009714

pyridothiazinone

16.  H. P. Yennawar, R. V. Bendinsky, D. J. Coyle, A. S. Cali, and L. J. Silverberg, “2,3-Diphenyl-2,3-dihydro-4H-1,3-benzothiazin-4-one,” Acta Cryst. Sect. E: Struct. Rep. Online 2014, E70, o465. (open access) doi:10.1107/S1600536814005881

benzo

15.  H. P. Yennawar and L. J. Silverberg, “2,3-Diphenyl-2,3,5,6-tetrahydro-4H-1,3-thiazin-4-one,” Acta Cryst. Sect. E: Struct. Rep. Online 2014 E70, o133. (open access) doi:10.1107/S1600536814000324  Corrigendum: 2015, E71, e5. http://journals.iucr.org/e/issues/2015/12/00/fy9019/index.html

thiazin

14.  H. P. Yennawar, L. J. Silverberg, M. J. Minehan, and J. Tierney, “2-(3-Nitrophenyl)-3-phenyl-2,3-dihydro-4H-1,3-benzothiazin-4-one” Acta Cryst. Sect. E: Struct. Rep. Online 2013, E69, o1679.  (open access) doi:10.1107/S1600536813028389

m-nitro

13.  L. J. Silverberg, E. R. Bear, K. N. Foose, K. A. Kirkland, R. R. McElvaney, K. Cannon, J. Tierney, S. Lascio, K. Mesfin, D. Mitchell, S. Sharkey, L. So, J. Treichel, M. Waxman, and A. Lagalante, “Verifying the predictability of 13C Chemical Shifts For A Series Of Substituted-2-(4-Chlorophenyl)-3-phenyl-1,3-thiazolidin-4-ones,” Int. J. Chem. (Toronto, ON, Can.) 2013, 5(4), 120-127.  (open access) http://www.ccsenet.org/journal/index.php/ijc/article/view/29911

C-chlorothiazolidinones

12.  H. P. Yennawar and L. J. Silverberg, “6,7-Diphenyl-5-thia-7-azaspiro[2.6]nonan-8-one,” Acta Cryst. Sect. E: Struct. Rep. Online 2013, E69, o1659.  (open access) doi:10.1107/S1600536813027979

11.  L. J. Silverberg, “Use of Doceri Software for iPad in Polycom and Resident Instruction Chemistry Classes,” J. Chem. Educ. 2013, 90, 1087-9. http://pubs.acs.org/doi/abs/10.1021/ed400093r

graph e

10.  L. J. Silverberg, S. Kelly, P. Vemishetti, D. H. Vipond, F. S. Gibson, B. Harrison, R. Spector, and J. L. Dillon, “A Crystallization-Induced Stereoselective Glycosyidation Reaction in the Synthesis of the Anticancer Drug Etoposide,” Org. Lett. 2000, 2, 3281-3.  http://pubs.acs.org/doi/abs/10.1021/ol006262n Correction: Org. Lett. 2000, 2, 3953.  http://pubs.acs.org/doi/abs/10.1021/ol006709s Featured in Chem. Eng. News 2000, 78, 41 (Oct. 9), p. 12. http://pubs.acs.org/doi/abs/10.1021/cen-v078n041.p012

etop

9.  L. J. Silverberg, J. L. Dillon, P. Vemishetti, P. D. Sleezer, R. P. Discordia, K. B. Hartung, and Q. Gao, “Efficient Synthesis of the Anticancer Drug Etoposide-4′-Phosphate; The Use of Benzylic Ether-Protecting Groups on the Carbohydrate Segment,” Org. Process Res. Dev. 2000, 4, 34-42. http://pubs.acs.org/doi/abs/10.1021/op990193e

etopophos

8.  S. Swaminathan, A. K. Singh, W. Li, J. J. Venit, K. J. Natalie Jr., J. H. Simpson, R. E. Weaver, and L. J. Silverberg, “A Chemoselective, Acid Mediated Conversion of Amide Acetal to Oxazole: The Key Step in the Synthesis of Cardiovascular Drug, Ifetroban Sodium,” Tetrahedron Lett. 1998, 39, 4769-72. http://www.sciencedirect.com/science/article/pii/S0040403998009046

ifet

7.  L. J. Silverberg, J. L. Dillon, and P. Vemishetti, “A Simple, Rapid and Efficient Protocol for the Selective Phosphorylation of Phenols with Dibenzyl Phosphite,” Tetrahedron Lett. 1996, 37, 771-4. http://www.sciencedirect.com/science/article/pii/0040403995022945

phosphorylation

6.  D. F. Taber, P. B. Deker, and L. J. Silverberg, “Enantioselective Ru-Mediated Synthesis of (-)-Indolizidine 223AB,” J. Org. Chem. 1992, 57, 5990-4.  http://pubs.acs.org/doi/abs/10.1021/jo00048a037

indolizidine

5.  D. F. Taber, L. J. Silverberg, and E. D. Robinson, “Cyclopentane Construction with Control of Side Chain Configuration: Enantioselective Synthesis of (+)-Brefeldin A,” J. Am. Chem. Soc. 1991, 113, 6639-45. http://pubs.acs.org/doi/abs/10.1021/ja00017a041

bfa

4.  D. F. Taber and L. J. Silverberg, “Enantioselective Reduction of beta-keto Esters,” Tetrahedron Lett. 1991, 32, 4227-30. http://www.sciencedirect.com/science/article/pii/S0040403900921348

3.  L. J. Silverberg, G. Wu, A. L. Rheingold, and R. F. Heck, “Palladium-Catalyzed Reactions of Vinyl Bromides and Disubstituted Alkynes: A New Synthesis of Fulvenes,” J. Organomet. Chem. 1991, 409, 411-20. http://www.sciencedirect.com/science/article/pii/0022328X9180026G

2.  A. L. Rheingold, D. L. Staley, R. F. Heck, and L. J. Silverberg, “(1Z,3E,5E,7Z)-1,2,3,4,5,6,7,8-Octaphenylocta-1,3,5.7-tetraene and 3,4-Diphenyl-isocoumarin,” Acta Cryst., Sect. C: Cryst. Struct. Commun.  1990, C46, 144-6. http://journals.iucr.org/c/issues/1990/01/00/issconts.html

1.  W. Tao, L. J. Silverberg, A. L. Rheingold, and R. F. Heck, “Alkyne Reactions with Arylpalladium Compounds,” Organometallics 1989, 8, 2550-9. http://pubs.acs.org/doi/abs/10.1021/om00113a006

alkynes

PATENTS:

13. L. J. Silverberg, “2,3-Diaryl-2,3-dihydro-4H-1,3-thiazin-4-one Compounds and Methods for Making,” US Patent Application 62/852,093, submitted May 23, 2019. https://patents.google.com/patent/WO2020237063A1/en?inventor=lee+silverberg&oq=lee+silverberg  (WO2020237063A1)

12. L. J. Silverberg, “S-Oxides of 2,3-Diaryl-2,3-dihydro-4H-1,3-thiazin-4-ones and 2,3-Diaryl-1,3-thiazepan-4-ones and Methods for Making” US Patent Application 62/846218, submitted May 10, 2019. https://patents.google.com/patent/WO2020231873A1/en?inventor=lee+silverberg&oq=lee+silverberg (WO2020231873A1)

11. L. J. Silverberg, “2,3-Diaryl-1,3-thiazepan-4-one Compounds and Methods for Making,” US Patent Application 62/846046, submitted May 10, 2019. https://patents.google.com/patent/WO2020231870A1/en?inventor=lee+silverberg&oq=lee+silverberg (WO2020231873A1)

10. R. Rossi, L. J. Silverberg. R Hogan, and R. M. Shah, “Method for Making and Storing Stable Cannabinoid Compositions and Method for Treatment Using Such Compositions,” U.S. Patent 9,814,775, 11/14/2017. https://patents.google.com/patent/US9814775B2/en

9. R. Rossi, L. J. Silverberg. R Hogan, and R. M. Shah, “Stable Cannabinoid Compositions and Methods for Making and Storing Them,” U.S. Patent 8,980,940, 3/17/2015. https://www.google.com/patents/US8980940?dq=8,980,940&hl=en&sa=X&ved=0CBwQ6AEwAGoVChMI3YSr483TyAIVRB8eCh0v5AIU

8.  R. Rossi, L .J. Silverberg. R Hogan, and R. M. Shah, “Composition Comprising (-)-Δ9-Trans-Tetrahydrocannabinol,” U.S. Patent 8,906,956, 12/09/2014. http://www.google.com.tr/patents/US8906956?utm_source=gb-gplus-sharePatent

7.  R. Rossi, L. J. Silverberg. R. Hogan, and R. M. Shah, “Composition Comprising (-)-Δ9-Trans-Tetrahydrocannabinol,” U.S. Patent 8,476,312, 07/02/2013. https://www.google.com/patents/US8476312?dq=8,476,312&hl=en&sa=X&ved=0CB0Q6AEwAGoVChMI0rP3-s3TyAIVBnceCh3stwOc

6.  R. Rossi, L. J. Silverberg. R. Hogan, and R. M. Shah, “Composition Comprising (-)-Δ9-Trans-Tetrahydrocannabinol,” U.S. Patent 8,039,509, 10/18/2011. https://www.google.com/patents/US8980940?dq=8,039,509&hl=en&sa=X&ved=0CCQQ6AEwAWoVChMIiInmic7TyAIVR10eCh2IDg1U

5.  L. J. Silverberg, “Synthesis of Cannabinoids,” U.S. Patent 7,186,850, 3/6/2007. http://www.google.com/patents/US7186850

thc

4.  L. J. Silverberg, T. M. Resnick, and M. L. Casner, “Uncatalysed Addition Reactions,” U.S. Patent 6,867,335, 3/15/2005. http://www.google.com/patents/US6867335

epoxide and diol

3.  L. J. Silverberg and P. Vemishetti, “Process for Preparing Etoposide,” European Patent 986569, 9/24/2003.

2.  L. J. Silverberg, P. Vemishetti, J. L. Dillon, and J. J. Usher, “Process of Preparing Etoposide Phosphate and Etoposide,” U.S. Patent 5,688,926, 11/18/1997. https://www.google.us/patents/US5688926

1.  L. J. Silverberg, P. Vemishetti, J. L. Dillon, and J. J. Usher, “Process of Preparing Etoposide Phosphate and Etoposide,” U.S. Patent 5,459,248, 10/17/1995. http://www.google.com/patents/US5459248

OTHER PUBLICATIONS:

4. L. Liporagi-Lopes, H. F. Sobhi, L. J. Silverberg, R. J. B. Cordero, A. Casadevall “Antifungal activity of 2,3-diphenyl-2,3-dihydro-1,3-thiaza-4-ones against two human pathogenic fungi,” posted on preprint server BioRxiv, June 27, 2020. https://www.biorxiv.org/content/10.1101/2020.06.27.175711v1

3. L . J. Silverberg, “What is an Organic Substance?” posted on preprint server ChemRxix, Nov. 27, 2018. https://chemrxiv.org/articles/What_is_an_Organic_Substance_/7382453

2. L. J. Silverberg, “Lab Safety Guidance” letter to the editor, Chem. Eng. News 2016, 94, 12 (Mar. 21), p. 3. http://cen.acs.org/articles/94/i12/Lab-safety-guidance.html

1.  L. J. Silverberg, “Asymmetric Catalysis,” Chem. Eng., June 1997, 39.