Project Team


Students

Kaleah Tuttle
Biomedical Engineering
University Park






Faculty Mentors

Dr. Laurel Seemiller
University Park
Department of Biology


Dr. Nicole Crowley
University Park
Department of Biology, Department of Biomedical Engineering








Project




https://sites.psu.edu/mcreu/files/formidable/2/2024-07-24/Tuttle-REU-Poster-1-2.pdf



Project Video




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Project Abstract


Alcohol abuse during adolescence is a significant problem in the United States. One characteristic of Alcohol Use Disorder is the compulsive nature of drinking alcohol, continuing to consume alcohol despite negative consequences. The relationship between adolescent binge drinking and adult alcohol consumption regarding this characteristic is not understood. For this experiment, male and female C57BL/6J mice consumed alcohol using the following protocol to examine compulsive drinking further: adolescent Drinking in the Dark (DID) and adult two-bottle choice (2BC) where 10% EtOH is adulterated with quinine hydrochloride. DID allows adolescent mice to drink large amounts of alcohol within a short period, replicating binge drinking in humans, and 2BC enables adult mice to drink alcohol voluntarily as the bitter tastant quinine is increasingly added, acting as a negative consequence for drinking alcohol to the mice. After all results are collected, conclusions can be drawn to determine if there is a significant relationship between adolescent binge drinking and adult alcohol consumption centered on its compulsive nature, establishing a new protocol for future research.




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