Kathleen M. Mulder, Ph.D.
We have identified the TGFβ receptor-interacting protein km23-1/dynlrb1, which plays an important role in TGFβ signal transduction, as well as in dynein-mediated intracellular transport of signaling cargoes to specialized locales. km23-1 also functions as a critical platform for the assembly of small GTPases, underlying its critical roles in cell signaling, motility, polarity, and in coupling TGFß receptor activation to activation of Ras effector pathways downstream. We are also investigating mechanisms of TGF-beta signaling in cancer and non-cancer cells, involving cell signaling, cell migration/invasion, actin cytoskeleton, motor proteins, intracellular trafficking, Ras, MAPKs, Smads, and dynein. Additional studies address how these events are altered in human cancers, as well as how km23-1 can be targeted therapeutically. The overall focus of the Mulder Lab is the identification of novel signal transduction-based therapeutics for human colon and pancreatic