Publications:
Liu, Q., Zhang, L., Allman, E., Hubbard, T.D., Murray, I.A., Zhang, J., Tian, Y., Gui, W., Smith, P.B., Anitha, M., Gonzalez, F.J., Perdew, G.H., and Patterson, A.D. (2021) The Aryl hydrocarbon receptor activates ceramide biosynthesis in mice contributing to hepatic lipogenesis. Toxicology doi: 10.1016/j.tox.2021.152831
Van den Bogaard, E.H., Esser, C., and Perdew, G.H. (2021) The enigma of aryl hydrocarbon activation through ligands and ligand metabolism: receptor signaling in skin inflammation. J. of Invest. Dermatology. 141, 1385-1388. doi:10.1016/j.jid.2020.12.013.
Murray, I.A., and Perdew G.H. (2020) How Ah Receptor Ligand Specificity Became Important in Understanding Its Physiological Function. Int. J. Mol. Sci. 21(24):9614. doi: 10.3390/ijms21249614.
Zhou, X., Li, D., Xu, W., Zhang, H., Wang, H., and Perdew, G.H. (2020) β-Naphthoflavone Activation of the Ah Receptor Alleviates Irradiation-Induced Intestinal Injury in Mice. Antioxidants (Basel) 9(12):1264. doi: 10.3390/antiox9121264.
Dong, F., and Perdew, G.H. (2020) The aryl hydrocarbon receptor as a mediator of host-microbiota interplay. Gut Microbes. 12(1):1859812. doi: 10.1080/19490976.2020.1859812.
Dong, F., Hao, F., Murray, I.A., Smith, P.B., Koo, I., Tindall, A.M., Kris-Etherton, P.M., Gowda, K., Amin, S.G., Patterson, A.D., and Perdew, G.H. (2020) Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity. Gut Microbes 12(1):1-24. doi: 10.1080/19490976.2020.1788899.
Dvorak, Z., Kopp, F., Costello, C.M., Kemp, J.S., Li, H., Vrzalova, A., Stepankova, M., Bartonkova, I., Jiskrova, E., Poulikova, K., Vyhlidalova, B., Nordstroem, L.U., Karunaratne, C., Ranhotra, H., Mun, K.S., Naren, A.P., Murray, I., Perdew, G.H., Brtko, J., Toporova, L., Schon, A., Wallace, B., Walton, W.G., Redinbo, M.R., Sun, K., Beck, A., Kortagere, S., Neary, M.C., Chandran, A., Vishveshwara, S., Cavalluzzi, M.M., Lentini, G., Cui, J.Y., Gu, H., March, J.C., Chaterjee, S., Matson, A., Wright, D., Flannigan, K.L., Hirota, S.A., and Mani, S. (2020) Targeting the Pregnane X Receptor Using Microbial Metabolite Mimicry. EMBO Mol. Med. 12(4):e11621. doi: 10.15252/emmm.201911621.
Muku, G.E., Blazanin, N., Dong, F., Smith P.B., Thiboutot, D., Gowda, K., Amin, S., Murray, I.A., and Perdew, G.H. (2019) Selective Ah receptor ligands mediate enhanced SREBP1 proteolysis to restrict lipogenesis in sebocytes. Toxicol. Sci. Epub.
Muku, G.E., Kusnadi, A., Kuzu, G., Tanos, R., Murray, I.A., Gowda, K., Amin, S., and Perdew, G.H. (2019) Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity. Laboratory Investigations. In Press.
Gourronc, F.A., Perdew, G.H., Robertson, L.W., and Klingelhutz, A.J. (2020) PCB126 blocks the thermogenic beiging response of adipocytes. Environmental Science and Pollution Res. 27(9):8897-8904. doi: 10.1007/s11356-019-06663-0.
Nichols, R.G., Zhang, J., Cai, J., Murray, I., Koo, I., Smith, P.B., Perdew, G.H., and Patterson, A.D. (2019) Metatranscriptomic Analysis of the Mouse Gut Microbiome Response to the Persistent Organic Pollutant TCDF. Metabolites. 10(1), pii: E1. doi: 10.3390/metabo10010001.
Muku, G.E., Murray, I.A., and Perdew, G.H. (2019) Activation of the Ah receptor modulates gastrointestinal homeostasis and the intestinal microbiome. Current Pharmacology Reports. 5, 319-331.
Tian, Y., Smith, P.B., Koo, I., Murray, I.A., Cantorna, M.T., Perdew, G.H., and Patterson, A.D. (2019) Isolation and Identification of aryl hydrocarbon receptor modulators in white button mushrooms (Agaricus bisporus) (2019) Metabolites. EPub.
Hubbard, T.D., Liu, Q., Murray, I.A., Dong, F., Miller, C., Smith, P.B., Gowda, K., Lin, J.M., Amin, S., Patterson, A.D. and Perdew, G.H. (2019) Microbiota metabolism promotes synthesis of the human Ah receptor agonist 2,8-dihydroquinoline. J Proteome Res. 18, 1715-1724.
Muku, G.E., Murray, I.A., Espín, J.C. and Perdew, G.H. (2018) Urolithin A is a dietary microbiota-derived human aryl hydrocarbon receptor antagonist. Metabolites. 29, pii: E86. doi: 10.3390/metabo8040086.
Esser, C., Lawerence, B.P., Sherr, D., Perdew, G.H., Puga, A., Barouki, R., and Coumoul, X. (2018) Old receptor, new tricks – the ever-expanding universe of aryl hydrocarbon receptor functions. International J. Mol. Sci. 15, pii: E3603. doi: 10.3390/ijms19113603.
Nichols, R.G., Cai, J., Murray, I.A., Koo, I., Smith, P.B., Perdew, G.H., and Patterson, A.D. (2018) Structural and Functional Analysis of the Gut Microbiome for Toxicologists. Current Protoc. Toxicol. 78(1): e54. doi: 10.1002/cptx.54.
Patterson, A.D., Gonzalez, F.J., and Peters, J.M. (2018) Molecular regulation of carcinogenesis: Friend or Foe. Toxicol Sci. 165, 277-283.
Belton, K.R., Tian, Y., Zhang, L., Anitha, M., Smith, P.B., Perdew, G.H.,and Patterson, A.D. (2018) Metabolomics reveals aryl hydrocarbon receptor activation induces liver and mammary gland metabolic dysfunction in lactating mice. J. Proteome Res. 17, 1375-1382.
Smith, K.J., Murray, I.A., Boyer, J.A., and Perdew, G.H. (2018) Allelic variants of the aryl hydrocarbon receptor differentially influence UVB-mediated skin inflammatory responses in SKH1 mice. Toxicology 394, 27-34.
Hubbard, T.D., Murray, I.A., Nichols, R.G., Cassel, K., Podolsky, M., Kuzu, G., Tian, Y., Smith, P., Kennett, M.J., Patterson, A.D., and Perdew, G.H. (2017) Dietary broccoli impacts microbial community structure and attenuates chemically induced colitis in mice in an Ah receptor dependent manner. J. Functional Foods. 37, 685-698.
Smith, K.J., Murray, I.A., Boyer, J.A., and Perdew, G.H. (2017) Allelic variants of the aryl hydrocarbon receptor differentially influence UVB-mediated skin inflammatory responses in SKH1 mice. Epub.
Smith, K.J., Boyer, J.A., Muku, G.E., Murray, I.A., Gowda, K., Desai, D., Amin, S.G., and Perdew, G.H. (2017) Editor’s Highlight: Ah receptor activation potentiates neutrophil chemoattractant (C-X-C motif) ligand 5 expression in keratinocytes and skin. Toxicol. Sci. 160, 83-94.
Muku, G.E., Lahoti, T.S., Murray, I.A., Podolsky, M.A., Smith, K.J., Hubbard, T.D., Kuzu, G., Gowda, K., Amin, S.G., and Perdew, G.H. (2017) Ligand-mediated cytoplasmic retention of the Ah receptor inhibits macrophage-mediated acute inflammatory responses. Lab. Invest. 97, 1471-1487.
Organtini, K.L., Hubbard, T.D., Perdew, G.H., and Dorman, F.L. (2017) Assessment of Ah receptor transcriptional activity mediated by halogenated dibenzo-p-dioxins and dibenzofurans (PXDD/Fs) in human and mouse cell systems. Journal of Environmental Science and Health, Part A. 52, 1295-1302.
Moyer, B.J., Rojas, I.Y., Murray, I.A., Lee, S., Hazlett, H.F., Perdew, G.H. and Tomlinson, C.R. (2017) Indoleamine 2,3-dioxygenase (IDO1) inhibitors activate the aryl hydrocarbon receptor. Toxicol. Appl. Pharamacol. 323, 74-80.
Murray, I.A., and Perdew, G.H. (2017) Ligand activation of the Ah receptor contributes to gastrointestinal homeostasis. Current Opinion in Tox. http://dx.doi.org/10.1016/j.cotox.2017.01.003
Koga, T., Yao, P-L., Goudarzi, M., Murray, I.A., Balandarum, G., Gonzalez, F.J., Perdew, G.H., Fornace, A.J., and Peters, J.M. (2016) Regulation of cytochrome P450 2B10 (CYP2B10) expression in liver by peroxisome proliferator-activated receptor-b/g modulation of SP1 promoter occupancy. J. Biol. Chem. 291, 25255-25263.
Murray, I.A., Nichols, R.G., Zhang, L., Albert, I., Patterson, A.D., and Perdew, G.H. (2016) Expression of the aryl hydrocarbon receptor is necessary to maintain intestinal host-microbe homeostasis. Sci Rep 6, 33969.
Hubbard, T.D., Murray, I.A., Bisson, W.H., Sullivan, A.P., Sebastian, A., Perry, G.H., Jablonski, N.G., and Perdew, G.H. (2016) Divergent Ah receptor ligand selectivity during hominin evolution. Mol. Biol. Evol. 33, 2648-58.
Balandaram, G., Kramer, L.R., Kang, B.H., Murray, I.A., Perdew, G.H., and Peters, J.M. (2016) Ligand activation of peroxisome proliferator-activated receptor-beta/gamma suppresses liver tumorigenesis in hepatitis B transgenic mice. J. Biol. Chem. 363-364, 109.
Gutierrez, M.A., Davis, S.S., Rosko, A., Nguyen, S.M., Mitchell, K.P., Mateen, S., Neves, J., Garcia, T.Y., Mooney, S., Perdew, G.H., Hubbard, T.D., Lamba, D.A., and Ramanathan, A. (2016) A novel AhR ligand 2AI, protects the retina from environmental stress. Sci. Rep. 6, 29025.
Girer, N.G., Murray, I.A., Zhang, L., Patterson, A., and Perdew, G.H. (2016) Hepatic aryl hydrocarbon receptor activity attenuates fibroblast growth factor 21 expression and modulates energy homeostasis. J. Biol. Chem. 291, 15378-87.
Yang, J., Hu, S., Perdew, G.H., and Xiong, N. (2016) Selective programming of regulatory CCR10+ innate lymphoid cells in skin-draining lymph nodes for cutaneous homeostatic regulation. Nature Immunol. 17, 48-56.