Congrats to Bo and Yiyun!
Link here:
A common genetic architecture enables the lossy compression of large CRISPR libraries | bioRxiv
Congrats to Bo and Yiyun!
Link here:
A common genetic architecture enables the lossy compression of large CRISPR libraries | bioRxiv
See the paper online here:
https://www.pnas.org/content/early/2020/02/07/1921649117
Congrats! This paper was an intense amount of work. We identified an exciting new design principle for targeted therapy and rational drug design. Preprint is here.
Final manuscript is forthcoming!
Our manuscript showing that CX-5461 acts through Topoisomerase II and creates collateral resistance to canonical Topoisomerase II poisons was just accepted at PNAS. This was a Terrific collaboration with Peter Bruno (Elledge Lab @ Harvard Med) and Michael Hemann (Koch Institute @ MIT). Manuscript is currently under embargo!
Great work by Haider! See the pre-print here.
This October, Bo and I published an exciting manuscript on the evolution of the Nonsense Mediated Decay (NMD) pathway in human tumors.
Nice work Kady. Kady is currently a sophmore at PSU but is really doing great in the lab!
Well done Haider and Scott!
This June Dr. Pritchard was awarded an NIBIB Trailblazer award for his grant on Dual-Switch Selection drives. The grant was reviewed by MABS study section and is funded through the Synthetic Biology and Applications focus area at the NIBIB.
Penn State’s Pritchard Lab merges the study of biomedical engineering and biological evolution. Led by Dr. Justin Pritchard, the lab’s research team uses engineering design to build cell systems, then they test their ability to control and understand the way populations of cells evolve. The team of scientists combine cell engineered models and quantitative experiments to better understand the design principles of successful small molecule therapy. Learn more.
Led by Dr. Daniel Hayes, Penn State’s Department of Biomedical Engineering is one of the fastest growing departments within in the university’s College of Engineering. Our curriculum is built upon the apex of engineering, medicine, healthcare policy and biological discovery. We prepare our students to become future leaders in the areas of medical device design, instrumentation, medical imaging, healthcare management, biomedical research and academia.
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The Huck Institutes at Penn State’s University Park campus catalyze and facilitate excellence in interdisciplinary research and education in the life sciences at Penn State, preparing students for successful careers and encouraging new perspectives across disciplinary boundaries.
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