We combine experiment and computation to characterize the pathology of complex diseases from molecular mechanism to physiological state, and everywhere in between. We use experimental techniques from molecular biophysics along with multi-plexing systems biology methods and -omics technologies to perform exploratory studies using human biosamples and mouse models, then use multivariate mathematical modeling and machine learning to uncover interactions associated with disease state. We then perturb those interactions in cell/tissue culture or in mouse models to engineer systems-level treatments and diagnostic solutions.
Some of our current projects include:
Sleep, Vascular Function, and Circadian Clearance of Molecular Species in Apolipoprotein E4-Associated Alzheimer’s Disease Risk
Associated lab members: Rachel Kang, Chaemin Kim
Molecular Mechanisms Underlying Neural Circuit Dysfunction in Alzheimer’s Disease
(Collaboration with Dr. Nanyin Zhang, Biomedical Engineering)
Associated lab members: Dennis Chan
In Vitro Modeling of Alzheimer’s Disease Using Cerebral Organoids Containing Native Microglia
Associated lab members: Chaemin Kim, Rachel Kang
For more information, contact Dr. Elizabeth Proctor at eproctor@psu.edu