(“*” denotes equal authorship)
Proctor Lab members
2024
- G. C. Smith, K. R. Griffith, A. R. Sicher, D. F. Brockway, E. A. Proctor, N. A. Crowley. “Moderate Alcohol Consumption Induces Lasting Impacts on Prefrontal Cortical Signaling in Mice,” bioRxiv doi:10.1101/2024.04.03.587955 (2024).
- D. C. Chan, C. Kim, R. Y. Kang, M. K. Kuhn, L. M. Beidler, N. Zhang, E. A. Proctor. “Cytokine expression patterns predict suppression of vulnerable neural circuits in a mouse model of Alzheimer’s disease,” bioRxiv doi:10.1101/2024.03.17.585383 (2024).
2023
- B. K. Ball, M. K. Kuhn, R. M. Fleeman, E. A. Proctor, D. K. Brubaker. “Differential responses of primary neuron-secreted MCP-1 and IL-9 to type 2 diabetes and Alzheimer’s disease-associated metabolites,” bioRxiv doi:10.1101/2023.11.17.567595 (2023).
- M. K. Kuhn, R. Y. Kang, C. Kim, Y. Tagay, N. Morris, E. D. Tabdanov, I. A. Elcheva, E. A. Proctor. “Dynamic neuroinflammatory profiles predict Alzheimer’s disease pathology in microglia-containing cerebral organoids,” bioRxiv doi:10.1101/2023.11.16.567220 (2023).
- M. K. Kuhn, R. M. Fleeman, L. M. Beidler, A. M. Snyder, D. C. Chan, E. A. Proctor. “Amyloid-β pathology-specific cytokine secretion suppresses neuronal mitochondrial metabolism,” Cellular and Molecular Bioengineering 16:405-421 (2023).
- E. Zukowski, M. Sannella, J. Donato Rockhold, G. Pugh, J. Yu, M. K. Kuhn, N. Hah, L. Ouyang, T.-W. Wang, M. Drummond, E. A. Proctor, H. Hasturk, B. S. Nikolajczyk, L. P. Bharath. “STAT3 Modulates CD4+ Mitochondrial Dynamics and Function in Aging,” Aging Cell 22:e13996 (2023).
- R. M. Fleeman, M. K. Kuhn, D. C. Chan, E. A. Proctor. “Apolipoprotein E4 modulates astrocyte neuronal support functions in the presence of amyloid-β,” Journal of Neurochemistry 165:536-549 (2023).
- R. M. Fleeman, A. M. Snyder, M. K. Kuhn, D. C. Chan, G. C. Smith, N. A. Crowley, A. C. Arnold, E. A. Proctor. “Predictive link between systemic metabolism and cytokine signatures in the brain of apolipoprotein E ε4 mice,” Neurobiology of Aging 123:154-169 (2023).
2022
- D. Y. Zhang, J. Wang, R. M. Fleeman, M. K. Kuhn, M. T. Swulius, E. A. Proctor, N. V. Dokholyan. “Monosialotetrahexosylganglioside Promotes Early Aβ42 Oligomer Formation and Maintenance,” ACS Chemical Neuroscience 13:1979-1991 (2022).
2021
- R. M. Fleeman and E. A. Proctor. “Astrocytic propagation of tau in the context of Alzheimer’s disease,” Frontiers in Cellular Neuroscience 15:645233 (2021).
- A. W. Simonson, A. S. Mongia, M. R. Aronson, J. N. Alumasa, D. C. Chan, A. Lawanprasert, M. D. Howe, A. Bolotsky, T. Mal, C. George, A. Ebrahimi, A. D. Baughn, E. A. Proctor, K. C. Keiler, S. H. Medina. “Pathogen-specific antimicrobials engineered de novo through membrane-protein biomimicry,” Nature Biomedical Engineering 5:467-480 (2021).
2020
- K. L. Turner, K. W. Gheres, E. A. Proctor, P. J. Drew. “Neurovascular coupling and bilateral connectivity during NREM and REM sleep,” eLife 9:e62071 (2020).
- R. M. Fleeman, G. Deiter, K. Lambert, E. A. Proctor, R. Phaëton. “Novel microRNA multivariate biomarkers of response to immunotherapy against HPV E6 oncogene,” bioRxiv doi:10.1101/2020.06.26.174441 (2020).
- E. A. Proctor, S. M. Dineen, S. C. Van Nostrand, M. K. Kuhn, C. D. Barrett, D. K. Brubaker, M. B. Yaffe, D. A. Lauffenburger, L. R. Leon. “Coagulopathy signature precedes and predicts severity of end-organ heat stroke pathology in a mouse model,” Journal of Thrombosis and Haemostasis 18:1900-1910 (2020).
- L. P. Bharath, M. Agrawal, G. McCambridge, D. A. Nicholas-Alvarado, H. Hasturk, J. Liu, K. Jiang, Z. Guo, J. Deeney, J. Snyder-Cappione, G. Hawk, R. M. Fleeman, R. M. F. Pihl, K. Thompson, A. C. Belkina, L. Cui, E. A. Proctor, P. A. Kern, B. S. Nikolajczyk. “Metformin enhances autophagy and normalizes mitochondrial function to alleviate aging-associated inflammation,” Cell Metabolism 32:44-55 (2020).
- C. S. Drapaca, S. Ozdemir, E. A. Proctor. “A Non-local Model of the Propagation of Action Potentials in Myelinated Neurons,” Emerging Science Journal 4:148-164 (2020).
- D. S. Nesterova, V. Midya, B. E. Zacharia, E. A. Proctor, S. Lee, L. Stetson, J. Lathia, J. Rubin, K. Waite, M. Berens, J. Barnholtz-Sloan, J. R. Connor. “Sexually dimorphic impact of the iron regulating gene, HFE, on survival in glioblastoma,” Neuro-Oncology Advances 2:vddaa001 (2020)
2019
- E. A. Proctor, D. D. Mowrey, N. V. Dokholyan. “β-Methylamino-L-alanine substitution of serine 107 in SOD1 suggests a direct role in ALS etiology,” PLOS Computational Biology 15:e1007225 (2019).
- D. Nicholas*, E. A. Proctor*, M. Agrawal, A. C. Belkina, S. C. Van Nostrand, L. Panneerseelan-Barath, A. R. Jones IV, F. Raval, B. C. Ip, M. Zhu, J. Cacecido, C. Habib, N. Sainz-Rueda, B. Corkey, C. Apovian, P. Kern, D. A. Lauffenburger, B. S. Nikolajczyk. “Fatty Acid Metabolites Combine with Reduced βOxidation to Activate Th17 Inflammation in Human Type 2 Diabetes,” Cell Metabolism 30:447-461 (2019) (“*” denotes equal authorship, alphabetical order)
- D. K. Brubaker, E. A. Proctor, K. M. Haigis, D. A. Lauffenburger. “Computational translation of genomic responses from experimental model systems to humans,” PLOS Computational Biology 15:e1006286 (2019).
2018
- A. C. Belkina, A. Starchenko, K. Drake, E. A. Proctor, D. A. Lauffenburger, J. Browning, A. Olsen, Y. Robles, L. Huang, N. Lin, J. E. Snyder-Cappione. “Multivariate computational analysis of gamma delta T cell inhibitory receptor signatures reveals the divergence of healthy and ART-suppressed HIV+ aging,” Frontiers in Immunology 9:2783 (2018).
- C. Wang, A. A. Aleksandrov, Z. Yang, F. Forouhar, E. A. Proctor, P. Kota, J. An, A. Kaplan, N. Khazanov, G. Boël, B. R. Stockwell, H. Senderowitz, N. V. Dokholyan, J. R. Riordan, C. G. Brouillette, J. F. Hunt. “Ligand binding to a remote site thermodynamically corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator,” Journal of Biological Chemistry 293:17685-17704 (2018).
- M. Fleury, A. Belkina, E. A. Proctor, C. Zammitti, R. Simms, D. A. Lauffenburger, J. Snyder-Cappione, R. Lafyatis, H. Dooms. “Increased Expression and Modulated Regulatory Activity of Co-Inhibitory Receptors PD-1, TIGIT, TIM-3 in Lymphocytes of Systemic Sclerosis Patients,” Arthritis & Rheumatology 70: 566-577 (2018).
2017
- D. Nicholas*, E. A. Proctor*, F. M. Raval*, B. C. Ip, C. Habib, E. Ritou, T. N. Grammatopoulos, D. Steenkamp, H. Dooms, C. M. Apovian, D. A. Lauffenburger, B. Nikolajczyk. “Advances in the Quantification of Mitochondrial Function in Primary Human Immune Cells through Extracellular Flux Analysis,” Public Library of Science ONE 12: e0170975 (2017). (“*” denotes equal authorship, alphabetical order)
- L. Liebenberg*, L. Masson*, K. Arnold*, L. McKinnon*, Werner L., E. A. Proctor, D. Archary, L. Werner, L. Mansoor, D. A. Lauffenburger, Q. Abdool Karim, S. Abdool Karim, J. Passmore. “Genital-systemic chemokine gradients and the risk of HIV acquisition in women,” Journal of Acquired Immune Deficiency Syndromes 74: 318-325 (2017). (“*” denotes equal authorship)
2016
- J. M. Fay*, C. Zhu*, E. A. Proctor, Y. Tao, W. Cui, H. Ke, N. V. Dokholyan. “A phosphomimetic mutation stabilizes SOD1 and rescues cell viability in the context of an ALS-associated mutation,” Structure 24: 1898-1906 (2016). (“*” denotes equal authorship)
- H. Hadi-Alijanvand, E. A. Proctor, F. Ding, N. V. Dokholyan, A. A. Moosavi-Movahedi. “A hidden aggregation-prone structure in the heart of hypoxia inducible factor prolyl hydroxylase,” Proteins: Structure, Function, and Bioinformatics 84: 611-623 (2016).
- E. A. Proctor and N. V. Dokholyan. “Applications of Discrete Molecular Dynamics in Biology and Medicine,” Current Opinion in Structural Biology 37: 9-13 (2016).
- E. A. Proctor, L. Fee, Y. Tao, R. L. Redler, J. M. Fay, Y. Zhang, L. Lv, I. P. Mercer, M. Deshmukh, Y. L. Lyubchenko, N. V. Dokholyan. “Non-native SOD1 trimer is toxic to motor neurons in a model of amyotrophic lateral sclerosis,” Proceedings of the National Academy of Sciences USA 113: 614-619 (2016). [Featured in F1000]
2015
- L. B. Wood, A. R. Winslow, E. A. Proctor, D. McGuone, D. A. Mordes, M. P. Frosch, B. T. Hyman, D. A. Lauffenburger, K. M. Haigis. “Identification of neurotoxic cytokines by profiling Alzheimer’s disease tissues and neuron culture viability screening,” Scientific Reports 5: 16622 (2015).
- E. A. Proctor, P. Kota, A. A. Aleksandrov, L. He, J. R. Riordan, N. V. Dokholyan. “Rational Allosteric Network Manipulation Rescues Disease-Relevant Mutant Cystic Fibrosis Transmembrane Conductance Regulator,” Chemical Science 6: 1237-1246 (2015).
2014
- S. Nedd, R. L. Redler, E. A. Proctor, N. V. Dokholyan, A. A. Alexandrova. “Cu,Zn-Superoxide Dismutase without Zn is Folded but Catalytically Inactive,” Journal of Molecular Biology 426: 4112-4124 (2014).
- S. S. Hasan, D. Baniulis, E. Yamashita, E. A. Proctor, N. V. Dokholyan, W. A. Cramer. “Traffic within the Cytochrome b6f Lipoprotein Complex: Gating of the Quinone Portal,” Biophysical Journal 107: 1620-1628 (2014).
- R. L. Redler, D. Shirvanyants, O. Dagliyan*, D. N. Kim*, P. Kota*, E. A. Proctor*, S. Ramachandran*, A. Tandon*, F. Ding, N. V. Dokholyan. “Computational approaches to understanding protein aggregation in neurodegeneration,” Journal of Molecular Cell Biology 6: 104-115 (2014). (“*” denotes equal authorship, alphabetical order)
2013
- N. Barison, L. Cendron, V. Loconte, E. A. Proctor, N. V. Dokholyan, G. Zanotti. “Protein HP1028 from the human pathogen Helicobacter pylori belongs to the lipocalin family,” Acta Crystallographica Section D 69: 1387-1394 (2013).
- E. A. Proctor, P. Kota, S. J. Demarest, J. A. Caravella, N. V. Dokholyan. “Highly covarying residues have a functional role in antibody constant domains,” Proteins: Structure, Function, and Bioinformatics 81: 884-895 (2013).
- E. A. Proctor, P. Kota, S. J. Demarest, J. A. Caravella, N. V. Dokholyan. “Metric to distinguish closely related domain families using sequence information,” Journal of Molecular Biology 425: 475-478 (2013).
2012
- H. Hadi-Alijanvand, E. A. Proctor, B. Goliaei, N. V. Dokholyan, A. A. Moosavi-Mohavedi. “Thermal unfolding pathway of PHD2 catalytic domain in three different PHD2 species: Computational approaches,” Public Library of Science ONE 7: e47061 (2012).
- E. A. Proctor, S. Yin, A. Tropsha, and N. V. Dokholyan. “Discrete molecular dynamics simulations distinguish the native and native-like binding poses from decoys in difficult drug targets,” Biophysical Journal 102: 144-151 (2012).
2011
- O. Dagliyan, E. A. Proctor, K. M. D’Auria, F. Ding, and N. V. Dokholyan. “Structural and dynamic determinants of protein-peptide recognition,” Structure 19: 1837-1845 (2011). [Cover article]
- R. L. Redler, K. C. Wilcox, E. A. Proctor, L. Fee, M. Caplow, and N. V. Dokholyan. “Glutathionylation at Cys 111 triggers dissociation of wild type and FALS mutant SOD1 dimers,” Biochemistry 50: 7057-7066 (2011). [Featured in F1000]
- E. A. Proctor, F. Ding, and N. V. Dokholyan. “Structural and thermodynamic effects of post-translational modifications in mutant and wild-type Cu, Zn superoxide dismutase,” Journal of Molecular Biology 408: 555-567 (2011). [Featured in F1000]
- H. Hadi-Alijanvand, M. Rouhani, E. A. Proctor, N. V. Dokholyan, and A. A. Moosavi-Mohavedi. “A folding pathway-dependent score to recognize membrane proteins,” Public Library of Science ONE 6: e16778 (2011).
- E. A. Proctor, F. Ding, and N. V. Dokholyan.“Discrete Molecular Dynamics,” Wiley Interdisciplinary Reviews: Computational Molecular Science 1: 80-92 (2011).
2009
- S. Yin, E. A. Proctor, A. A. Lugovskoy, and N. V. Dokholyan. “Fast screening of protein surfaces using geometric invariant fingerprints,” Proceedings of the National Academy of Sciences USA 106: 16622-16626 (2009). [Featured in F1000]
2007
- K. J. Seu, A. P. Pandey, F. Haque, E. A. Proctor, A. E. Ribbe, and J. S. Hovis. “Effect of surface treatment on diffusion and domain formation in supported lipid bilayers,” Biophysical Journal 92: 2445-2450 (2007).