Epithelial cells form barriers that divide different compartments in the body. Epithelial cells include the cells lining the intestine, lungs, kidney tubules, and milk ducts. These cells are normally stationary but become migratory during processes such as the repair of tissue damage or the metastasis of epithelial tumors. The Santy lab is interested in understanding the signals and processes that initiate migration in epithelial cells. The development of motility involves large changes in the architecture and behavior of these cells. We are focused on mapping out signals that remodel the cell and kick off epithelial migration.
Watch this American Cancer Society video featuring the Santy Lab