Biophysical chemistry is a discipline that merges an interest in the systems and processes from biochemistry with the principles and quantitative laws from physical chemistry. In the Showalter Laboratory, we make broad use of solution nuclear magnetic resonance (NMR) spectroscopy, in combination with thermodynamic analysis, chemical biology, and cellular assays to advance understanding of protein function. We place special emphasis on biophysical studies of macromolecular interactions involving partially disordered proteins. All of the systems investigated by our group are chosen for their importance in eukaryotic gene regulation. While we specialize in fundamental research, we are always mindful of our potential to advance molecular understanding of transcription and gene regulation, which we envision having sustained societal and biomedical impact.
For details, please click the Research link above.
Fall 2019 Recruiting:
The Showalter Laboratory is accepting rotation students from both Chemistry and BMMB for the fall semester. If you are interested in joining our group, please email Dr. Showalter.
The Showalter Laboratory is also actively recruiting two postdoctoral scholars to work on our recently awarded NIH and NSF projects. Formal job descriptions will be posted soon, but in the meantime interested applicants can email Dr. Showalter with inquiries. We are especially interested in applicants with either (1) NMR experience who are looking to develop their skills in NMR pulse programming or (2) cellular biology experience, broadly defined, looking to develop their skills in a biochemical and structural biology setting.
Check out our ABB review on NMR of Intrinsically Disordered Proteins.
Nature Communications: Sequence-Specific Conformational Changes in RNA Pol II CTD.
Nature Communications: Conformational Heterogeneity in RNA Pol II CTD.
The Showalter Laboratory is proud to be a part of the Center for Eukaryotic Gene Regulation (CEGR). The research interests of all CEGR members are focused on understanding the mechanisms of gene regulation, although each member brings unique perspectives and expertise. What this means for trainees in the Showalter Laboratory and for our science is a world-class, immersive, and multi-disciplinary environment in which we apply the tools and theories we love toward biological and biomedical advances in gene regulation.The CEGR is the recipient of an NIH predoctoral training grant in eukaryotic gene regulation.