Research published prior to tenure-track appointment:
16. Tang, Y., Crane-Moscowitz, K., Sinha, N.J., Guo, R., Kloxing, C. J., Saven, J.G., Pochan, D. J. (2023). Pathway dependent self-assembly of positively charged computationally designed coiled coil peptide ‘bundlemer’ chains. In preparation.
15. Sheth, T.,* Sinha, N. J.*, Okayama, Y., Hawker, C. J. & Helgeson, M. E. Spontaneous De-Mixing of Cosurfactants Stabilize Water-In-Oil Core-Shell Nano-Emulsions. In preparation. (*equal contribution)
14. Sinha, N. J., Cunha, K., Murphy, R., Shea, J. E., Hawker, C. J., Helgeson, M. E. (2023). Competition Between Beta-Sheet and Coacervate Domains Yield Diverse Morphologies in Mixtures of Oppositely Charged Homochiral Peptides. Biomacromolecules, XXXX. https://doi.org/10.1021/acs.biomac.3c00361
-Manuscript selected for ACS Editor’s Choice
-Manuscript selected for Rising Stars in Soft and Biological Matter symposium 2022
13. Garcia, R. V., Murphy, E., Sinha, N. J., Okayama, Y., Urueña, J. M., Helgeson M. E., Bates, C., Murphy, R. D., Hawker, C. J., & Read de Alaniz, J. (2023). Tailoring Writability and Performance of Star Block Copolypeptides Hydrogels through Side‐Chain Design. Small, 2302794. https://doi.org/10.1002/smll.202302794
12. Shannon, D. P., Moon, J. D., Barney, C. W., Sinha, N. J., Yang, K. C., Jones, S. D., Garcia, R. V., Helgeson, M. E., Segalman, R. A., Valentine, M. T., & Hawker, C. J. (2023). Modular Synthesis and Patterning of High-Stiffness Networks by Postpolymerization Functionalization with Iron–Catechol Complexes. Macromolecules, 56(6), 2268-2276. https://doi.org/10.1021/acs.macromol.2c02561
11. Bailey, S. J., Barney, C. W., Sinha, N. J., Pangali, S. V., Hawker, C. J., Helgeson, M. E., Valentine, M. T., & de Alaniz, J. R. (2022). Rational mechanochemical design of Diels–Alder crosslinked biocompatible hydrogels with enhanced properties. Materials Horizons. https://doi.org/10.1039/D2MH00338D
10. Guo, R., Sinha, N. J., Misra, R., Tang, Y., Langenstein, M., Kim, K., Fagan, J. A., Kloxin, C. J., Jensen, G. V., Pochan, D. J., & Saven, J. G. (2022). Computational Design of Homotetrameric Peptide Bundle Variants Spanning a Wide Range of Charge States. Biomacromolecules, 23(4), 1652-1661. https://doi.org/10.1021/acs.biomac.1c01539
9. Villegas, J. A.*, Sinha, N. J.*, Teramoto, N., Von Bargen, C. D., Pochan, D. J., & Saven, J. G. (2022). Computational Design of Single-Peptide Nanocages with Nanoparticle Templating. Molecules, 27(4), 1237. https://doi.org/10.3390/molecules27041237 (* equal contribution)
8. Sinha, N. J., Guo, R., Misra, R., Fagan, J., Faraone, A., Kloxin, C. J., Saven, J., Jensen, G., & Pochan, D. J. (2022). Colloid-like solution behavior of computationally designed coiled coil bundlemers. Journal of Colloid and Interface Science, 606, 1974-1982. https://doi.org/10.1016/j.jcis.2021.09.184
-Manuscript highlighted in NCNR Accomplishments and Opportunities report 2022 https://nvlpubs.nist.gov/nistpubs/SpecialPublications/NIST.SP.1284.pdf
Bundlemer (grey cylinders) solution structure at various concentrations (C) and length scales (Q-1) is dictated by short-range attraction (green) and long-range repulsion (yellow) interactions.
7. Sinha, N. J., Langenstein, M. G., Pochan, D. J., Kloxin, C. J., & Saven, J. G. (2021). Peptide Design and Self-assembly into Targeted Nanostructure and Functional Materials. Chemical Reviews, 121(22), 13915-13935. https://doi.org/10.1021/acs.chemrev.1c00712
6. Sinha, N. J., Shi, Y., Tang, Y., Kloxin, C. J., Saven, J. G., Faraone, A., Jensen, G., & Pochan, D. J. (2021). Intramolecular structure and dynamics in computationally designed peptide-based polymers displaying tunable chain stiffness. Physical Review Materials, 5(9), 095601.https://doi.org/10.1103/PhysRevMaterials.5.095601
-Manuscript highlighted in NCNR Accomplishments and Opportunities report 2022 https://nvlpubs.nist.gov/nistpubs/SpecialPublications/NIST.SP.1284.pdf
Schematic of hybrid physical-covalent assembly of polymers formed via (a) direct linkage and (b) flexible small molecular linker. (c) Small-angle neutron scattering (SANS) data for a concentration series of the semirigid polymers (“Chain”, red circles) and rigid rodlike polymers (“Rod”, blue squares) and corresponding fits to semiflexible cylinder and straight cylinder models.
5. Sinha, N. J., Kloxin, C., Saven, J., Jensen, G., Kelman, Z., Pochan, D. (2021) Recombinant expression of computationally designed peptide-bundlemers in Escherichia coli, Journal of Biotechnology 330, 57-60. https://doi.org/10.1016/j.jbiotec.2021.03.004
4. Sinha, N. J., Wu, D., Saven, J., Kloxin, C., Jensen, G., Pochan D. (2019) Polyelectrolyte character of rigid rod peptide bundlemer chains constructed via hierarchical self-assembly, Soft Matter 15 (48), 9858-9870. https://doi.org/10.1039/C9SM01894H
-Manuscript highlighted in NCNR Accomplishments and Opportunities report 2020 https://nvlpubs.nist.gov/nistpubs/SpecialPublications/NIST.SP.1257.pdf
3. Wu, D., Sinha, N. J., Lee, J-Y., Zhang, H., Saven, J., Kloxin, C., Pochan D. (2019) Polymers with Controlled Assembly and Rigidity Made with Click-functional Peptide Bundles, Nature 574 (7780), 658-662. https://doi.org/10.1038/s41586-019-1683-4
-Manuscript highlighted in NCNR Accomplishments and Opportunities report 2020 https://nvlpubs.nist.gov/nistpubs/SpecialPublications/NIST.SP.1257.pdf
-Manuscript highlighted in UDaily news https://www.udel.edu/udaily/2019/october/bundlemers-darrin-pochan-chris-kloxin-new-polymer-term-coined/
-Manuscript highlighted in ScienceDaily news https://www.sciencedaily.com/releases/2019/10/191030155834.htm
2.Haider, M., Zhang, H., Sinha, N. J., Saven, J., Kiick, K., Pochan, D. (2018) Self-assembly and soluble aggregate behavior of computationally designed coiled coil peptide bundles, Soft Matter 14 (26), 5488-5496. https://doi.org/10.1039/C8SM00435H
1.Nisal, A., Venugopalan, P., Sinha, N. (2014) Silk based porous scaffold and a process for the preparation thereof. Patent WO Appl. 2014125505A1. https://patents.google.com/patent/WO2014125505A1/en
-Culminated in commercial product: https://serigenmed.com/serioss/
