Squire J. Booker is an Evan Pugh Professor of Chemistry and of Biochemistry and Molecular Biology, and the Eberly Family Distinguished Chair in Science at the Pennsylvania State University. He is also an investigator of the Howard Hughes Medical Institute. He received a B.A. degree with a concentration in chemistry from Austin College in 1987 and a Ph.D. in biochemistry from the Massachusetts Institute of Technology in 1994, where he was supervised by Prof. JoAnne Stubbe. He received an NSF–NATO postdoctoral fellowship to study at the Université René Descartes in Paris, France under the supervision of Dr. Daniel Mansuy, and then an NIH postdoctoral fellowship to study at the Institute for Enzyme Research at the University of Wisconsin under the supervision of Prof. Perry Frey. He joined the faculty at Penn State in 1999, and was promoted to Associate Professor in 2005, Professor in 2013, Eberly Family Distinguished Chair in Science in 2017, and Evan Pugh Professor in 2018. Booker’s research focuses on the enzymology of natural product biosynthesis, with a particular interest in the methylation or sulfidation of unactivated carbon centers, and the use of S-adenosylmethionine and iron-sulfur clusters in enzyme catalysis. In addition to his scientific endeavors, he is heavily involved in the mentoring of young scientists, and particularly those that come from groups that are historically underrepresented in the sciences. Currently, he is the PI on an NSF award entitled “Interactive Mentoring And Grantsmanship Enhancement,” which seeks to demystify the grant-writing process for early stage investigators. Among other awards, Booker received a CAREER award from the National Science Foundation, a Presidential Early Career Award in Science and Engineering (PECASE), and an ACS Cope Scholar award. He was elected a fellow of the American Association for the Advancement of Science in 2013, a member of the American Academy of Arts and Sciences in 2017, and a member of the National Academy of Sciences in 2019.