Associate Professor
Pediatric Hematology/Oncology
Department: Pediatrics
Email: sxd30@psu.edu
Phone: 717-531-0003 x280286
Research Interests:
Leukemia, transcription factor IKZF1/Ikaros, cancer epigenetics
Systems/Organs:
Hematopoietic, Blood
Cell/Cellular compartments:
Lymphoid, myeloid blood cells
Signaling pathways:
NOTCH, Wnt, STAT, PI3K
Diseases/Conditions:
Leukemia
Focus Groups: Cancer Stem Cells; Hematopoiesis;
Research description: Basic/Translational
Investigate the role of lymphoid master regulator, IKZF1/Ikaros, in the development of acute lymphoblastic leukemia (ALL); other transcriptional factors in leukemia; CK2 activity; chromatin remodeling; super-enhancers.
Technical expertise: molecular biology: molecular cloning, ChIP-Seq, qChIP, Luciferase Assay; GO analysis;
Selected Publications:
- Ge Z, Zhou X, Gu Y, Han Q, Li J, Chen B, Ge Q, Dovat E, Payne JL, Sun T, Song C, Dovat S.Ikaros regulation of the BCL6/BACH2 axis and its clinical relevance in acute lymphoblastic leukemia. Oncotarget. 2016 Dec 20. doi: 10.18632/oncotarget.14038.
- Gowda C, Sachdev M, Muthisami S, Kapadia M, Petrovic-Dovat L, Hartman M, Ding Y, Song C, Payne JL, Tan BH, Dovat S. Casein kinase II (CK2) as a therapeutic target for hematological malignancies. Curr Pharm Des. 2016 Oct 06. PMID: 27719640.
- Dovat S. Ikaros: The enhancer makes the difference. Blood. 2013 Oct 31; 122(18):3091-2. PMID: 24178958; PMCID: PMC3814726.
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