Disease modeling, cell fate/transdifferentiation, pathophysiological and molecular aspects of schizophrenia.
cellular responses to dopamine, ketamine etc.,
Focus Group: Neuroscience;
Research description: Translational/Basic
Using the transdifferentiation model for the generation of neuronal-like cells from blood circulating monocytes, Bellon’s laboratory studies how cellular responses to neurotransmitters and other compounds in neuronal-like cells from patients with schizophrenia differ from those in normal individuals.
Technical expertise: directed differentiation of primary monocytes to neuron-like cells.
- Merelo V, Durand D, Lescallette AR, Vrana KE, Hong LE, Faghihi MA, Bellon A. Associating schizophrenia, long non-coding RNAs and neurostructural dynamics. Front Mol Neurosci. 2015; 8:57. PMID: 26483630;
- Bellon A, Krebs MO, Jay TM. Factoring neurotrophins into a neurite-based pathophysiological model of schizophrenia. Prog Neurobiol. 2011 Jun; 94(1):77-90.