Assistant Professor of Dermatology
The Jake Gittlen Laboratories for Cancer Research
Department: Dermatology
Email: anelson@pennstatehealth.psu.edu
Phone: x28451
Research Interests:
Skin stem cells skin homeostasis, inflammatory skin diseases, innate immunity
Systems/Organs:
Skin
Cell/Cellular compartments:
Keratinocytes, fibroblasts, epidermis, dermis, sebaceous glands and hair follicles
Signaling pathways:
TLRs, epithelial to mesenchymal transition (EMT), inflammatory pathways
Diseases/Conditions:
Acne vulgaris, hidradenitis suppurativa, non-melanoma skin cancer, skin microbiome
Focus Groups: Integumentary; Immunomodulatory;
Research description: Translational
Our lab has translational research projects focused on understanding the pathogenesis of inflammatory skin diseases. In addition, we study the role of skin stem cells and EMT during wound healing/chronic inflammation.
Technical expertise: in vitro cell culture, some in vivo models, human
Selected Publications:
- Nelson AM, Reddy SK, Ratliff TS, Hossain MZ, Katseff AS, Zhu AS, Chang E, Resnik SR, Page C, Kim D, Whittam AJ, Miller LS, Garza LA. dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration. Cell Stem Cell. 2015 Aug 6; 17(2):139-51.
- Nelson AM, Dispenza MC, Cong Z, Moll M, Gilliland KL, Thiboutot DM. Selective Rho Kinase Inhibitor Allows for Expansion of Human Primary Sebocytes In Vitro. J Invest Dermatol. 2016 Jun; 136(6):1278-80.
- Nelson AM, Zhao W, Gilliland KL, Zaenglein AL, Liu W, Thiboutot DM. Neutrophil gelatinase-associated lipocalin mediates 13-cis retinoic acid-induced apoptosis of human sebaceous gland cells. J Clin Invest. 2008 Apr; 118(4):1468-78.
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