Cell Therapies

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  Exploring therapeutic applications of adult stem and progenitor cells for tissue and organ repair.

Studying chemical and pathogens intervention to healing and aging.

Ectoderm

Brain Regeneration

The revolutionary approach to restore the endogenous pull of neurons through the direct conversion striatal astrocytes into GABAergic neurons was developed by the former Penn State professor Dr. Gong Chen and his team. Read the news and the paper recently published in Nature Communication.

Neural Stem Cells

Dr. Inan Olmez’s research program consists of neuroscience and tumor biology. From the neuroscience perspective, his laboratory is interested in the biology of neural stem cells and the mechanisms of cellular reprogramming. The goal is to enable brain tissue healing or regeneration through promoting cellular reprogramming towards neural stem cells. From the tumor biology standpoint, Dr. Olmez’s research focuses on the biology of glioma stem, or tumor-initiating, cells and aims to determine how differentiated glioblastoma (GBM) cells reprogram their phenotype to become glioma stem cell-like cells. These studies will help to develop more effective therapies against GBM.

Modeling of Schizophrenia

Using the transdifferentiation model for the generation of neuronal-like cells from blood circulating monocytes, Dr. Bellon’s laboratory studies how cellular responses to neurotransmitters and other compounds in neuronal-like cells from patients with schizophrenia differ from those in normal individuals. To visist Alfredo Bellon profile, click here

Vision Loss in Retinal Disease

Dr. Sundstrom’s research program focuses on the development of biomarkers and novel therapeutic targets for age-related macular degeneration (AMD), the leading cause of legal blindness in the United States. Dr. Sundstrom has developed a deep proteomics assay capable of identifying retinal derived proteins from clinical vitreous samples. To read about Dr. Sundstrom’s research, click here.

Mesoderm

Angiogenesis

Dr. Dino Ravnic laboratory’s primary research effort is toward the creation of autologous vascularized engineered tissue that is suitable for microsurgical implantation and immediate reperfusion. To learn more about Dr. Ravnic research, click here.

Adipose-derived Mesenchymal Stem Cells

Dr. Koduru’s research has focused on developing functional pancreatic beta cells from human adipose stem cells and making their molecular signature comparable with native human pancreatic beta cells using various advanced molecular techniques. These projects are done in an effort to find a solution to diabetes.

Bone Marrow Mesenchymal Stem Cells

Dr. Christopher Niyibizi’s lab studies the biology of adult bone marrow-derived MSCs and their potential for skeletal repair and regeneration. The focus of the investigation is to understand engraftment characteristics of the cells and their fate when transplanted in vivo. The research uses animal models of skeletal diseases to explore the potential of stem cell therapy for the skeleton. To learn more, click here.

Endoderm

Lung Regeneration

Dr. Zissis Chroneos’ overall research focuses on understanding how surfactant proteins modulate host defense and inflammation in the lung, with a major current focus on influenza pathogenesis, and host pathogen interactions,innate and adaptive immune responses to bacterial and viral infections. To learn more,  visit Dr. Chroneos’e research profile.

Gut Disease and Regeneration

Drs Gregory S. Yochum and Wei Ding use human organoid models to assess the role of stem cells in homeostasis of the intestinal epithelium, inflammatory bowel disease, and colorectal cancer. To learn more about their research or contanct investigators, visit Dr. Yochum and Dr. Ding research profiles.