Assistant Professor
Pediatric Hematology/Oncology
Department: Pediatrics
Email: csong@pennstatehealth.psu.edu
Phone:717-531-1841
Research Interests:
Leukemia, Epigenetics of cancer, Hematopoietic Stem Cells
Systems/Organs:
Hematopoietic, Blood
Cell/Cellular compartments:
Lymphoid, myeloid blood cells, DNA, promoters, enhancers, histone modifications
Signaling pathways:
JAK-STAT, NF-κB, Wnt, PI3K
Diseases/Conditions:
Leukemia, Neuroblastoma, others
Focus Groups: Cancer Stem Cells; Hematopoiesis;
Research description: Basic/Translational
Investigate the role of lymphoid master regulator, IKZF1/Ikaros, in the development of acute lymphoblastic leukemia (ALL); other transcriptional factors in leukemia; CK2 activity; chromatin remodeling; super-enhancers.
Technical expertise: molecular biology: molecular cloning, ChIP-Seq, qChIP, Luciferase Assay; GO analysis;
Selected Publications:
- Song C, Pan X, Ge Z, Gowda C, Ding Y, Li H, Li Z, Yochum G, Muschen M, Li Q, Payne KJ, Dovat S. Epigenetic regulation of gene expression by Ikaros, HDAC1 and Casein Kinase II in leukemia. Leukemia. 2016 Jun; 30(6):1436-40.
- Song C, Gowda C, Pan X, Ding Y, Tong Y, Tan BH, Wang H, Muthusami S, Ge Z, Sachdev M, Amin SG, Desai D, Gowda K, Gowda R, Robertson GP, Schjerven H, Muschen M, Payne KJ, Dovat S. Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia. Blood. 2015 Oct 8; 126(15):1813-22.
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