Vasculature, autologous vascularized engineered tissue, tissue engineering, reconstructive surgery
breast, bone, others
adipose-derived stem cells (ADSCs) and their differentiated progenies, small RNAs
VEGFR, Angiopoietin/TIE receptor, Eph receptor, PDGFR signal transduction,
PI3K, Ras/MAP kinase
Breast cancer, hernia, tissue repair;
Focus Groups: Vasculature; Bioengineering;
Research description: Translational/Regenerative
Microvascular development, integration, and function; creation of autologous vascularized engineered tissue for microsurgical implantation and immediate reperfusion; scaffold fabrication, 3D bioprinting assembly of cells/scaffolds/proteins. The cross-collaborative environment has led to additional projects in tissue repair (e.g. hernia, bone) and the investigation of small RNAs for both clinical implementation and integration into tissue engineering approaches.
Technical expertise: isolation and differentiation of adipose-derived stem cells (ADSCs) into multiple cell lines; three-dimension (3D) culture of ADSCs and recombining them with endothelial cells derived from the same adipose fraction in vitro; isolation of various proteins and molecules from adipose tissue and using them in scaffold fabrication; bioinformatics;
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