Mechanisms of programmed cell death: apoptosis and autophagy; anti-cancer therapies; drug discovery.
Blood cells, others
WNT/β-catenin, Hedgehog, TGFa, EGF, TNF, PI3K, others
Research description: Basic/Translational
The ultimate goal of Dr. Wang’s research is to translate discoveries in the field of programmed cell death such as apoptosis and autophagy, to the development of new approaches for anti-cancer therapies. To achieve this goal, his laboratory focuses on understanding fundamental mechanisms that control apoptosis (a cell’s self-killing mechanism) and autophagy (a cell’s self-eating process) in the context of oncogenesis.
Technical expertise: variety of molecular and cell biology techniques; leukemia induction in mice; engraftment studies; drug development and screening;
- Young MM, Takahashi Y, Fox TE, Yun JK, Kester M, Wang HG. Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking. Cell Rep. 2016 Nov 1; 17(6):1532-1545.
- Doi K, Gowda K, Liu Q, Lin JM, Sung SS, Dower C, Claxton D, Loughran TP, Amin S, Wang HG. Pyoluteorin derivatives induce Mcl-1 degradation and apoptosis in hematological cancer cells. Cancer Biol Ther. 2014; 15(12):1688-99.
- Takahashi Y, Hori T, Cooper TK, Liao J, Desai N, Serfass JM, Young MM, Park S, Izu Y, Wang HG. Bif-1 haploinsufficiency promotes chromosomal instability and accelerates Myc-driven lymphomagenesis via suppression of mitophagy. Blood. 2013 Feb 28; 121(9):1622-32.