PhD Research Assistant
Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802
The Multiscale Biomechanics and Mechanobiology Lab is seeking a qualified and highly motivated PhD student to study the role of mechanics in tendon development. Specifically, this research will investigate how tendon hierarchical mechanics are established during development and determine the role that cellular mechano-transduction plays in this process. The work will involve manipulation of chick embryos, multiscale mechanical testing of embryonic tendons, computational modeling, cell culture, and various biological assays. Applicants must have a BS degree in Biomedical Engineering, Mechanical Engineering, Physics, or a related field. Candidates with expertise in chick embryology, mechanical testing of biological tissues, and mechanobiology are preferred. Successful applicants must demonstrate strong motivation, critical scientific thinking and creativity, capable project leadership, and good communication skills.
The Multiscale Biomechanics and Mechanobiology lab is part of the Departments of Biomedical Engineering and Orthopaedics & Rehabilitation at the Pennsylvania State University. Our research investigates the interplay between tendon multiscale mechanics and mechanobiology in the context of tissue remodeling (e.g., degeneration, repair, and development). The ultimate goals of this work are to identify the causes of tendon pathology, discover novel therapeutic options, and direct the design of biomaterials that can recapitulate the behavior of native tissue. Furthermore, our research will produce fundamental knowledge regarding the feedback loop between local tissue mechanics and cellular mechanobiology, which is an important contributor to numerous diseases outside orthopaedics, including tissue fibrosis and cancer.