A full list of publications is available online via NCBI My Bibliography:
2023
, , , , . Cyclic loading induces anabolic gene expression in ACLs in a load-dependent and sex-specific manner. J Orthop Res. 2023; In Press. doi:10.1002/jor.25677
Mouse Achilles tendons exhibit collagen disorganization but minimal collagen denaturation during cyclic loading to failure. J Biomech. 2023 Apr;151:111545. doi: 10.1016/j.jbiomech.2023.111545.
Tendon cell and tissue culture: Perspectives and recommendations. J Orthop Res. 2023 Feb 16;41: 2093-2104. doi: 10.1002/jor.25532.
Measuring Local Tissue Strains in Tendons via Open-Source Digital Image Correlation. J Vis Exp.2023 Jan 27;(191). doi: 10.3791/64921.
2022
Pedaprolu K, Szczesny SE (2022) A Novel, Open-Source, Low-Cost Bioreactor for Load-Controlled Cyclic Loading of Tendon Explants. J Biomech Eng 144:084505.
Paschall L, Pedaprolu K, Carrozzi S, Dhawan A, Szczesny SE (2022) Mechanical Stimulation as Both the Cause and the Cure of Tendon and Ligament Injuries. In Sarah Greising, Jarrod Call (Eds.), Regenerative Rehabilitation, Physiology in Health and Disease, Springer, pp 359–386.
2021
Peterson BE, Rolfe RA, Kunselman A, Murphy P, Szczesny SE (2021) Mechanical Stimulation via Muscle Activity Is Necessary for the Maturation of Tendon Multiscale Mechanics During Embryonic Development. Front Cell Dev Biol. 9:725563.
2020
Peterson BE, Szczesny SE (2020) Dependence of tendon multiscale mechanics on sample gauge length is consistent with discontinuous collagen fibrils. Acta Biomaterialia 117: 302-309.
Szczesny SE (2020) Ex vivo models of musculoskeletal tissues. Connect Tissue Res 61(3-4):245-247.
2018
Gong Z, Szczesny SE, Caliari SR, Charrier EE, Cao X, Lin Y, Mauck RL, Janmey PA, Burdick JA, Shenoy VB (2018) Matching material and cellular timescales maximizes cell spreading on viscoelastic substrates. PNAS 115: E2686-E2695..
Szczesny SE, Aeppli C, David A, Mauck RL (2018) Fatigue loading of tendon results in collagen kinking and denaturation but does not change local tissue mechanics. J Biomech 71: 251-256.
Heo SJ, Szczesny SE, Kim DH, Saleh KS, Mauck RL (2018) Expansion of mesenchymal stem cells on electrospun scaffolds maintains stemness, mechano-responsivity, and differential potential. J Orthop Res 36: 808-815.
2017
Safa BN, Meadows KD, Szczesny SE, Elliott DM (2017) Exposure to buffer solution alters tendon hydration and mechanics. J Biomech 61: 18-25.
Lee A, Szczesny SE, Santare MH, Elliott DM (2017) Investigating mechanism of tendon damage by measuring multi-scale recovery following tensile loading. Acta Biomaterialia 57: 363-372.
Szczesny SE, Fetchko KL, Dodge GR, Elliott DM (2017) Evidence that interfibrillar load transfer in tendon is supported by small diameter fibrils and not extrafibrillar tissue components. J Orthop Res 35: 2127-2134.
Bansal S, Mandalapu S, Aeppli C, Qu F, Szczesny SE, Mauck RL, Zgonis MH (2017) Mechanical function near defects in an aligned nanofiber composite is preserved by inclusion of disorganized layers: Insight into meniscus structure and function. Acta Biomaterialia 56: 102-109.
Szczesny SE, Mauck RL (2017) The nuclear option: evidence implicating the cell nucleus in mechanotransduction. J Biomech Eng 139(2): 021006.
Loebel C, Szczesny SE, Cosgrove BD, Alini M, Zenobi-Wong M, Mauck RL, Eglin D (2017) Crosslinking chemistry of tyramine-modified hyaluronan hydrogels alters mesenchymal stem cell early attachment and behavior. Biomacromolecules 18(3): 855-864.
2016
Szczesny SE, Driscoll TP, Tseng HY, Liu PC, Heo SJ, Mauck RL, Chao PG (2016) Crimped nanofibrous biomaterials mimic microstructure and mechanics of native tissue and alter strain transfer to cells. ACS Biomat Sci & Eng 3: 2869-2876.
Heo SJ, Han WM, Szczesny SE, Cosgrove BD, Elliott DM, Lee DA, Duncan RL, Mauck RL (2016) Mechanically induced chromatin condensation requires cellular contractility in mesenchymal stem cells. Biophys J 111: 864-874.
2014 – 2015
Szczesny SE, Caplan JL, Pedersen P, Elliott DM (2015) Quantification of interfibrillar shear stress in aligned soft collagenous tissues via notch tension testing. Scientific Reports 5: 14649.
Szczesny SE, Elliott DM (2014) Incorporating plasticity of the interfibrillar matrix in shear lag models is necessary to replicate the multiscale mechanics of tendon fascicles. J Mech Behav Biomed 40: 325-338.
Szczesny SE, Edelstein RS, Elliott DM (2014) DTAF dye concentrations commonly used to measure microscale deformations in biological tissues alter tissue mechanics. PLoS ONE 9(6): e99588.
Szczesny SE, Elliott DM (2014) Interfibrillar shear stress is the loading mechanism of collagen fibrils in tendon. Acta Biomaterialia 10(6): 2582-2590. (Awarded Acta Student Award)
2010 – 2012
Szczesny SE, Peloquin JM, Cortes DH, Kadlowec J, Soslowsky LJ, Elliott DM (2012) Biaxial tensile testing and constitutive modeling of human supraspinatus tendon. J Biomech Eng 134(2): 021004.
Matuszewski PE, Chen YL, Szczesny SE, Lake SP, Elliott DM, Soslowsky LJ, Dodge GR (2012) Regional variation in human supraspinatus tendon proteoglycans: decorin, biglycan, and aggrecan. Conn Tiss Res 53(5): 343-348.
Lee CS, Szczesny SE, Soslowsky LJ (2011) Remodeling and repair of orthopedic tissue: Role of mechanical loading and biologics; Part 2: Cartilage and Bone. Am J Orthop 40(3): 122-128.
Szczesny SE, Lee CS, Soslowsky LJ (2010) Remodeling and repair of orthopedic tissue: Role of mechanical loading and biologics; Part 1: Tendon and ligament; meniscus. Am J Orthop 39(11): 525-530.