Ongoing Research Support
NIH R01GM141792-01 Nanyin Zhang (PI) 08/01/2021 – 05/31/2025
Title: Elucidating dynamic reorganization of whole-brain networks during anesthetic-induced unconsciousness
The objective of this project is to comprehensively elucidate the dynamic reorganization of the whole-brain functional network to support different patterns of information exchange from the awake state into an unconscious state.
NIH R01NS085200 Nanyin Zhang (PI) 9/1/2013-3/31/2025
Title: Resting-state Neural Networks in Awake Rodents
The major goal of this project is to elucidate the causal impact of manipulating hub region activity on brain network organization, function and behavior in awake rats using rsfMRI, DREADDs, optogenetics and electrophysiology.
Completed Research Support (last 3 years)
NIH R01NS101353 Patrick Drew (Contact PI),Nanyin Zhang (MPI) 09/25/2017-06/30/2023
Title: A multimodal approach to understanding the development of neurovascular coupling
The goal of this proposal is to understand how neurovascular coupling changes through development.
NIH R21AG068532 Elizabeth Proctor (Contact PI), Nanyin Zhang (MPI) 05/01/2021 – 04/30/2023
Title: Coupling and Spread of Molecular and Functional Pathology of Alzheimer’s Disease
The objective of this project is to demonstrate the progression of mitochondrial dysfunction and neuroinflammation along pathways of pathologically changing functional connectivity in the Alzheimer’s brain.
NIH RF1MH114224 Nanyin Zhang (Contact PI), Patrick Drew (MPI) 7/21/2017-5/30/2022
Title: Mechanistic dissection of the neural basis of the resting-state fmri signal using multi-modal approaches
The primary goal of this application is to elucidate the neural basis of resting-state functional magnetic resonance imaging (rsfMRI) signal using multi-modal approaches including multi-echo (ME)-rsfMRI, MR-compatible calcium signal recording, optogenetics and multi-laminar electrophysiology in awake rats.