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Artificial Heart & Cardiovascular Fluid Dynamics Lab

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Welcome

Welcome to the Artificial Heart Lab and Cardiovascular Fluid Dynamics Lab. This research facility has been in existence since the early 1970s as Penn State faculty and researchers at the Hershey Medical Center and the University Park campus worked towards the development of a total artificial heart. Over the past 30 years, this work has lead to commercially available devices, which are used today. The research focuses on the use of experimental flow measurement techniques to understand and eliminate areas of blood damage and thrombus deposition associated with cardiovascular devices (artificial hearts, ventricular assist devices, prosthetic heart valves, etc.). We also use in vitro blood studies to assess the potential damage these devices may induce.

Over the years, this lab has been lead by Winfred Philips, Ph.D., David Gesolowitz, Ph.D., Roger Gaumond, Ph.D., John M. Tarbell, Ph.D., and Steven Deutsch, Ph.D. As we have a long history in this area, I intend to continue the fine work that preceded me and I have been part of already and move into more fundamental areas to improve cardiovascular devices and minimize host responses.

Dr. Keefe B. Manning

Dr. Manning is a professor in biomedical engineering at Penn State and heads the Artificial Heart and Cardiovascular Fluid Dynamics Lab. Read More…

Recent Publications

Aycock KI, Campbell RL, Lynch FC, Manning KB, Craven BA. The Importance of Hemorheology and Anatomy on the Hemodynamics in the Inferior Vena Cava. Ann Biomed Eng. 2016 Jun 6.

Taylor JO, Meyer RS, Deutsch S, Manning KB. Development of a computational model for macroscopic predictions of device-induced thrombosis. Biomech Model Mechanobiol. 2016 May 12.

Good BC, Deutsch S, Manning KB. Continuous and Pulsatile Pediatric Ventricular Assist Device Hemodynamics with a Viscoelastic Blood Model. Cardiovasc Eng Technol. 2016 Mar;7(1):23-43. doi: 10.1007/s13239-015-0252-8. Epub 2015 Dec 7.

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