Tag Archives: Awards

Physiological Adaptations to Stress Training Grant, What is it All About?

Clockwise from front row right: Adwitia Dey, Kelly Ness, Billie Alba, Zhi Chai, and James Hester. Not pictured: Paul Hsu (Hershey Campus).
Current Physiology Training Grant Students. Clockwise from front right: Adwitia Dey, Kelly Ness, Billie Alba, Zhi Chai, and James Hester. Not pictured: Paul Hsu (Hershey Campus).

In 2014, the Intercollege Graduate Degree Program in Physiology secured one of the National Institutes of Health’s prestigious pre-doctoral training grants. Titled, “Physiological Adaptations to Stress,” the program provides students in the sciences with interdisciplinary training by exposing them to diverse but relevant fields of study such as law and business. The grant provides funding and access to unique coursework to two to four students per year for three years each.

Various research topics are covered by current trainees on the grant, including the role of mitochondrial dysfunction in aging and vascular stress, chronic and disease-mediated inflammatory effects on the central nervous system, intestinal epithelial response to microbial infection in a vitamin A deficient state, and the effects of sleep restriction on adipocyte function. I am a member of the second cohort to be added to the grant, so I thought I would ask my fellow trainees some questions about being members of an interdisciplinary training grant.

In the fall of 2014, the first cohort of four students took a course on entrepreneurship through the business school. I asked Paul Hsu, a joint MD-PhD student at Hershey Medical Center and a member of the initial cohort of trainees, about the course.

“The entrepreneurship class was a good, broad introduction into the issues encountered by start-up businesses and the major obstacles that are encountered as a company grows. The course provided an environment to learn how to plan and direct the development of a company into a variety of endpoints (rapid growth, lifestyle entrepreneur, etc.),” said Hsu.

I think it is especially important to highlight how unique of an opportunity it is for graduate students in the hard sciences to take business and law school classes. This year’s cohort had the chance to take a business school course called Team Process, which I found to be an incredible experience. It exposed me to an entirely different way of thinking and seeing the world and taught me how to communicate more effectively. My fellow cohort member, Adwitia Dey, agrees: “The curriculum has taught me to evaluate my personal skills candidly and learn to work on my weaknesses actively, particularly [when] working in a team setting. This training will most definitely impact my future as a career scientist whether I follow a path in academia or industry because being an effective team member is important in all capacities.”

This summer, all six current trainees will have the opportunity to partake in a two-week intensive course on science patent law, a topic far beyond most doctoral training programs, but a critical aspect of many scientists’ current and future careers. Other focuses of the training include effective scientific communication to diverse audiences and a capstone course taught by faculty from numerous departments, entitled Physiological Adaptations to Stress. I cannot overstate the importance or honor of being a part of this training grant as the interdisciplinary training it provides will allow us to more effectively navigate future careers in the sciences and in science-related fields. I highly recommend that students from a broad range of science fields and from throughout the Huck Institutes of the Life Sciences apply to be a part of this unique training opportunity.

 

For more information about the training grant see here: https://www.huck.psu.edu/content/graduate-programs/biomedical-stress-physiology

Nobel Prize Recap

Over the past few days, the Nobel Prize committees have announced the 2015 winners for the three science-based Nobel Prizes: Medicine or Physiology, Physics, and Chemistry. So who are these people, and why do they deserve the Nobel Prize?

Here’s everything you need to know:

1. Nobel Prize in Physics

Source: Reuters

Who: Takaaki Kajita and Arthur B. McDonald
What for:  “The discovery of neutrino oscillations, which shows that neutrinos have mass”
Why we care: During the 1960’s, scientists calculated the theoretical number of neutrinos created by the nuclear reactions of the sun (which is what gives us light), and the amount of them that should reach Earth. When compared to measurements on Earth however, about 1/3 to 2/3 of the neutrinos that should reach us could not be found. While there were plenty of theories about why this happened, none of them were proven until Kajita and McDonald came along. Kajita showed that neutrinos in our atmosphere can switch between two identities before they reach the instruments we use to measure them. McDonald then showed that we’ve only been measuring neutrinos of a single identity. As Rachel Feltman of the Washington Post explains, “if we can only detect tortilla chips, then we might not detect the ones that turn into Doritos”. To continue this analogy, McDonald set his machines to detect Doritos and found that those numbers accounted for the missing “chips”, erm, neutrinos from our original measurements on Earth. Most importantly, Kajita and McDonald’s data show that neutrinos, which scientists thought were mass-less particles, do actually have a mass. This revelation not only disproves part of the Standard Model of physics, but may also help us to determine how neutrinos could have influenced the birth of the Universe.

2. Nobel Prize in Medicine or Physiology

Source: Flizz India

Who: William C. Campbell, Satoshi Omura, and Youyou Tu
What for: To Campbell and Omura for “discoveries concerning a novel therapy against infections caused by roundworm parasites” and to Tu for “her discoveries concerning a novel therapy against Malaria”
Why we care: Parasitic disease in humans is a constant threat to public health. One such disease, Lymphatic Filariasis, afflicts more than 100 million people across the world. Unfortunately, scientists have not been able to develop any effective therapies to date. That is, until now. The award committee acknowledges Campbell’s and Omura’s research that led to the discovery of a new class of compounds that has so far been extremely effective in treating parasitic diseases. Meanwhile, Tu is credited for her 1970’s discovery of a separate class of chemicals that is highly effective against malaria. By the 1960’s, early attempts to treat malaria were proving unsuccessful. Meanwhile, the number of malaria cases continued to rise across the globe. Digging deep into the ancient literature on Chinese herbal medicine, Tu was able to extract a chemical called Artemisinin, and demonstrate that it rapidly kills malarial parasites during their early developmental stages. To this day, the drug is still used for treating severe cases of malaria.

3. Nobel Prize in Chemistry

Source: Reuters

Who: Tomas Lindahl, Paul Modrich, and Aziz Sancar
What for: “having mapped, at a molecular level, how cells repair damaged DNA and safeguard the genetic information”
Why we care: Every time a cell divides in our body, our DNA must be copied in its entirety, letter by letter. This happens millions of times each day. However, our body isn’t perfect and so for every 100,000,000 letters read, our cells will on accidentally copy a wrong letter. With all the DNA replications that happen each day in your body, this means your DNA should mutate hundreds of times each week. However, that does not happen. What Lindahl, Modrich, and Sancar discovered is that the body is able to detect these copying errors and fix them. Their research is incredibly important for understanding how the body works at a molecular level, and may even help us understand how cells become cancerous and how we might be able to prevent it.

Student Leader Spotlight Series: Jennifer Legault, Chair of the HGSAC

Jen and labmate, Angela Grant, modeling an MRI scanner

I couldn’t think of a better position to kick off the Student Leader Spotlight Series than with one near and dear to my heart – the Chair of the Huck Graduate Student Advisory Committee (HGSAC). This year, that title belongs to Jennifer Legault, a fourth year student in the Neuroscience program working in Dr. Ping Li’s lab. Jen’s work both inside and outside of the lab focuses on communication: when she isn’t taking care of HGSAC business or discussing important graduate student issues with the Huck administration, she’s completing her thesis work by using multimodal imaging to study how the brain changes when you learn a second language.

The HGSAC, a relatively new organization that was started in January 2015, is made up of graduate student representatives from the six Huck programs as well as from the BMMB program with the mission of representing the graduate student population as a whole by promoting their interests and advocating on important issues. The goals of the HGSAC include, but are not limited to, acting as a voice of the graduate student body by facilitating communication among students, faculty, and administration; providing career and professional development resources; and facilitating the interaction between the individual Huck programs, as well as with Huck programs and other departmental programs, on both a professional and social level. The HGSAC has numerous leadership positions, including the Chair and Associate Chair, a title held by Colleen McSweeney, also a fourth year student in the Neuroscience program.

The Chair of the HGSAC is a position taken on by the student who is awarded the Graduate Adviser to the Huck Institutes fellowship for that calendar year, so chairing the HGSAC is only part of the responsibility that comes with the fellowship. Other responsibilities include attending weekly graduate education meetings with Huck administration, gathering feedback about Huck-related events for the Huck administration, and organizing the Career Exposure Seminar Series & Events page as well as the Career & Professional Development page.

As the Graduate Adviser to the Huck Institutes fellowship/Chair of the HGSAC are fairly new positions, taking on this leadership role is no easy task. In order to successfully lead this group of graduate students, Jennifer commented that she thinks delegation and teamwork are two necessary skills to possess. “Deciding which tasks are best left for me to perform and which tasks are more appropriate for one or several of my fellow committee members to perform takes up a considerable amount of my time in the beginning but saves me a lot of time later on,” said Jennifer. “I am so grateful to be surrounded by so many competent and dedicated committee members.” As the founder and first Chair of the HGSAC, I wholeheartedly agree with Jen that the key to the success of the HGSAC is the teamwork of all members involved.

Graduate students are already busy with the everyday tasks of classes, teaching, and lab work, so how does one balance an additional leadership role? “Every week, I make a list of things I need to prioritize — some weeks, I will dedicate more time to HGSAC, and other times I might need to delegate more so I can accomplish what I need to do for my research,” said Jen.

Jen is no stranger to taking on leadership positions. She was on two HGSAC subcommittees (social and budget) last year, has taught a general research methods lab course for the past two years, and was a resident adviser for three years as an undergraduate student at Tulane University. When asked what is one characteristic she believes every leader should possess, Jen chose open-mindedness: “I think that great things happen when you have a group of people who think very differently and can all work on a problem together”.

Jen_Adirondacks
Jen is no stranger to tough situations – here she is at an extreme adventures course in the Adirondacks!

In my opinion, strong leaders aren’t just born that way – they learn from others and hone their skills as they gain more experience. For Jen, she said that it was her Area Director, Fatou Mbye, in her last year as a resident adviser that had the biggest impact on her as a leader. As an Area Director, Fatou was in a similar position as Jen in that both positions require leading a group of leaders. It was from Fatou that Jen learned the importance of communication, how to address conflict in a group, and how to balance professionalism while still getting personable with those in the group.

For those students who might be thinking about taking on a leadership position themselves, Jen had this advice to offer: learn to delegate properly and don’t be afraid to ask questions or seek advice from other leaders. “If you have a problem that you aren’t sure how to tackle, chances are that someone else has also stumbled upon this problem and might be able to help you. No one is perfect, and most problems don’t have one clear solution. It’s okay to ask for help,” added Jen. For more advice and resources on leadership, check out the HGSAC website, read our blog posts on leadership, and, perhaps most importantly, go out and talk to other leaders as well as your peers to learn about what qualities they look for in a leader.

11 Students Receive 2015 Huck Dissertation Research Grant

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20150715_161527
Huck Dissertation Research Grant 2015 winners. Back row (left to right): Beng San Yeoh, Yafei Lyu, James Hester, William Barnes, Weile Chen. Front row (left to right): Siyang Hao, Yue Rui, Ningxiao Li. Not pictured: Wilfried Guiblet, Di Wu, and Lihua Wu. Credit: Carrie Lewis.

 

The Huck Institutes of the Life Sciences is pleased to announce the recipients of the 2015 Huck Dissertation Research Grants. This award provides students in the six Huck Institutes-supported graduate programs up to $5,000 towards their individual research projects. The intent of this award is for the students to propose a unique research project that represents their original synthesis and extends beyond the research in their adviser’s lab.

This year’s winners are:

  • William Barnes (Plant Biology), working with Dr. Charles Anderson
  • Weile Chen (Ecology), working with Dr. David Eissenstat
  • Wilfried Guiblet (Bioinformatics and Genomics), working with Dr. Kateryna Makova and Dr. Anton Nekrutenko
  • Siyang Hao (Molecular, Cellular, and Integrative Biosciences), working with Dr. Robert Paulson and Dr. Zhi-Chun Lai
  • James Hester (Physiology), working with Dr. Francisco Diaz
  • Ningxiao Li (Plant Biology), working with Dr. Seogchan Kang
  • Yafei Lyu (Bioinformatics and Genomics), working with Dr. Qunhua Li
  • Yue Rui (Plant Biology), working with Dr. Charles Anderson
  • Di Wu (Bioinformatics and Genomics), working with Dr. John Carlson
  • Lihua Wu (Plant Biology), working with Dr. Teh-hui Kao
  • Beng San Yeoh (Immunology and Infectious Disease), working with Dr. Matam Vijay Kumar

As part of the application, students submit a three-page research proposal written in the style of an NIH or NSF proposal with a budget and budget justification, which is then reviewed by three faculty members familiar with the research discipline. “This year, 18 faculty members kindly agreed to serve as evaluators, with each evaluator reading and scoring between 4-8 proposals (≤7 on average),” said Dr. Pam Mitchell, Associate Director of the Huck Institutes of the Life Sciences and organizer of the proposal evaluation process. “We encourage all faculty who belong to Huck graduate programs to participate as Dissertation Award proposal evaluators as they provide an extremely important service that benefits the entire Penn State life science community.” Although thesis advisors of current applicants are ineligible to serve as evaluators, it’s hopeful that these faculty will be especially motivated to serve in subsequent years.

These grants are funded through the Huck Institutes Graduate Enrichment Fund as part of an endowment from J. Lloyd Huck, Penn State alumnus, philanthropist, and former chairman of Merck & Co. The annual award was created in 2013, and with a roughly 30% funding rate, it has allowed students in their second and third years of their Ph.D. program the opportunity and funding to support their own research.

One of the recipients, Weile Chen (Ecology), wanted to emphasize his appreciation that these funds are now available to support unique aspects of his research. “I am working on inter-specific competition of tree roots, and one of the challenges is to identify different species of the co-occurring similar-looking roots,” said Chen. “Using these funds, I’ll have the opportunity to use molecular techniques to solve this problem by sequencing the root DNA at the genomic core facility here at Penn State.” Chen also added that the process of applying for the grant and writing the proposal was a great learning process.

William Barnes (Plant Biology) noted that receiving this award for a proposal on a high-risk, high-reward project encourages the path of research he plans to take and is also motivating for his personal efforts. “Using this support, I have the opportunity to develop a tool critical to our understanding of plant cell wall biology with the experts of the field,” said Barnes. “I look forward to being able to use this generous support to the fullest while advancing my personal training and the field that I work for so passionately.”

James Hester (Physiology) commented on what an honor it is to receive this award and how it will provide funding for travel and publication costs, which will allow him to focus more on his project rather than worry about how he and his lab will support these efforts. Hester also added, “One of the great benefits of this award is that it will allow me to try some new reagents and techniques that might not have been in the budget otherwise.”

Lihua Wu (Plant Biology) said she plans to use her award money for buying new lab supplies as well as costs associated with maintaining the lab’s microscope, sequencing, and traveling to conferences. “I appreciate that the Huck Institutes are so supportive to graduate students!” said Wu. Wilfried Guiblet (Bioinformatics and Genomics) also added, “I just want to thank the Huck Institutes for all of the opportunities they are providing and their support overall. It is a pleasure to be a graduate student in such a place.”

 

This article cross-posted from: http://www.huck.psu.edu/content/about/news-archive/announcing-huck-dissertation-research-grant-2015-winners