Research Highlights
M. A. Miller et al. Adv. Funct. Mater. 2024: 2402514.
I. Kim et al. Small. 2023, 19(46): 2301673.
A. Lawanprasert et al. Small. 2022, 18(46): 2203751.
J. N. Sloand et al. Adv. Funct. Mater. 2021, 31(40): 2104223.
A. W. Simonson et al. Biomaterials. 2021, 273: 120848.
A. W. Simonson et al. Nat. Biomed. Eng. 2021, 5(5): 467-480.
*corresponding author, °co-first author
2024
(42.) M. A. Miller, S. H. Medina*. Life at the interface: Engineering bio-nanomaterials through interfacial molecular self-assembly. WIREs Nanomedicine and Nanobiotechnology. 2024.
(41.) M. A. Miller, S. H. Medina*. Synthetic Colonic Mucus Enables the Development of Modular Microbiome Organoids. Advanced Functional Materials. 2024: 2402514
2023
(40.) I. Kim, J. C. Elliott, A. Lawanprasert, G. M. Wood, J. C. Simon, S. H. Medina*. Real-Time, In Situ Imaging of Macrophages via Phase-Change Peptide Nanoemulsions. Small. 2023. 19(46): 2301673.
Highlighted in NSF News
(39.) A. Lawanprasert°, J. N. Sloand°, M. González Vargas, H. Singh, T. Eldor, M. A. Miller, S. Pimcharoen, J. Wang, S. M. Leighow, J. R. Pritchard, N. V. Dokholyan, S. H. Medina*. Deciphering the mechanistic basis for perfluoroalkyl-protein interactions. ChemBioChem. 2023. 24(13): e202300159.
(38.) A. H. Guadagno, S. H. Medina*. The Manifold Role of Octapeptide Repeats in Prion Protein Assembly. Peptide Science. 2023. 115(2): e24303.
(37.) N. A. Crowley*, S. H. Medina*. Targeted and transient opening of the blood brain barrier in discrete neurocircuits and brain regions. Neuropsychopharmacology. 2023. 48(1): 253
Hot Topics Issue
2022
(36.) S. H. Medina*. Voices in Molecular Pharmaceutics: Meet Dr. Scott Medina, Manipulator of Biomaterial Properties for Precision Therapeutics. Molecular Pharmaceutics. 2022. 19(12): 4392.
(35.) A. Lawanprasert°, S. Pimcharoen°, S. E. Sumner, C. T. Watson, K. B. Manning, G. S. Kirimanjeswara, S. H. Medina*. Heparin-Peptide Nanogranules for Thrombosis-Actuated Anticoagulation. Small. 2022. 18(46): 2203751.
(34.) M. M. Hale, S. H. Medina*. Biomaterials-Enabled Antithrombotics: Recent Advances and Emerging Strategies. Molecular Pharmaceutics. 2022. 19(12): 4453–4465.
(33.) A. Lawanprasert, A. W. Simonson, S. E. Sumner, M. J. Nicol, S. Pimcharoen, G. S. Kirimanjeswara, S. H. Medina*. Inhalable SARS-CoV-2 Mimetic Particles Induce Pleiotropic Antigen Presentation. Biomacromolecules. 2022. 23(3): 1158-1168.
2021
(32.) J. N. Sloand, E. Rokni, C. T. Watson, M. A. Miller, K. B. Manning, J. C. Simon, S. H. Medina*. Ultrasound-Responsive Nanopeptisomes Enable Synchronous Spatial Imaging and Inhibition of Clot Growth in Deep Vein Thrombosis. Advanced Healthcare Materials. 2021: 2100520.
(31.) J. N. Sloand, T. E. Culp, N. M. Wonderling, E. D. Gomez, S. H. Medina*. Mechanomorphogenic Films Formed via Interfacial Assembly of Fluorinated Amino Acids. Advanced Functional Materials. 2021, 31(40): 2104223.
(30.) A. W. Simonson, T. M. Umstead, A. Lawanprasert, B. Klein, S. Almarzooqi, E. S. Halstead, S. H. Medina*. Extracellular Matrix-Inspired Inhalable Aerogels for Rapid Clearance of Pulmonary Tuberculosis. Biomaterials. 2021, 273: 120848.
(29.) A. Lawanprasert, A. Chau, J. N. Sloand, S. Hannifin, S. H. Medina*. Tuning the Interfacial Properties of Fluorous Colloids Towards Ultrasound Programmable Bioactivity. ACS Applied Materials & Interfaces. 2021, 13(5): 5989-5998.
(28.) M. R. Aronson, S. H. Medina, M. J. Mitchell*. Peptide functionalized liposomes for receptor targeted cancer therapy. APL Bioengineering. 2021, 5(1): 011501.
(27.) A. W. Simonson, A. S. Mongia, M. R. Aronson, J. N. Alumasa, D. C. Chan, A. Lawanprasert, M. D. Howe, A. Bolotsky, T. K. Mal, C. George, A. Ebrahimi, A. D. Baughn, E. A. Proctor, K. C. Keiler, S. H. Medina*. Pathogen-specific antimicrobials engineered de novo through membrane-protein biomimicry. Nature Biomedical Engineering. 2021, 5(5): 467-480.
Highlighted in Nature Research Bioengineering Community, Penn State News and Genetic Engineering & Biotechnology News
2020
(26.) J. N. Sloand, M. A. Miller, S. H. Medina*. Fluorinated Peptide Biomaterials. Peptide Science. 2020, doi.org/10.1002/pep2.24184.
(25.) A. W. Simonson, M. R. Aronson, S. H. Medina*. Supramolecular Peptide Assemblies as Antimicrobial Scaffolds. Molecules. 2020, 25(12): 2751.
(24.) M. R. Aronson, E. S. Dahl, J. A. Halle, A. W. Simonson, R. A. Gogal, A. B. Glick, K. M. Aird, S. H. Medina*. Re-engineering Antimicrobial Peptides into Oncolytics Targeting Drug-Resistant Ovarian Cancers. Cellular and Molecular Bioengineering. 2020: 1-15.
(23.) J. N. Sloand, T. T. Nguyen, S. A. Zinck, E. C. Cook, T. J. Zimudzi, S. A. Showalter, A. B. Glick, J. C. Simon, S. H. Medina*. Ultrasound-Guided Cytosolic Antibody Delivery via Transient Fluorous Masks. ACS Nano. 2020, 14(4): 4061-4073.
(22.) A. Lawanprasert, C. A. Guinan, E. S. Langford, C. E. Hawkins, J. N. Sloand, H. W. Fescemyer, M. R. Aronson, J. A. Halle, J. H. Marden*, S. H. Medina*. Discovery of Antitumor Lectins from Rainforest Tree Root Transcriptomes. PLoS One. 2020,15(2): e0229467.
(21.) Y.-M. Tu, W. Song, T. Ren, Y. Shen, R. Chowdhury, P. Rajapaksha, T. E. Culp, L. Samineni, C. Lang, A. Thokkadam, D. Carson, Y. Dai, A. Mukthar, M. Zhang, A. Parshin, J. N. Sloand, S. H. Medina, M. Grzelakowski, D. Bhattacharya, W. A. Phillip, E. D. Gomez, R. J. Hickey, Y. Wei, M. Kumar*. Rapid Fabrication of Precise, High-Throughput Filters from Membrane Protein Nanosheets. Nature Materials. 2020, 19(3): 347-354.
2019
(20.) A. W. Simonson, A. Lawanprasert, T. D. P. Goralski, K. C. Keiler, S. H. Medina*. Bioresponsive Peptide-Polysaccharide Nanogels – A Versatile Delivery System to Augment the Utility of Bioactive Cargo. Nanomedicine. 2019, 17: 391-400.
(19.) S. H. Medina*, B. Bush, M. Cam, E. Sevcik, F. W. DelRio, K. Nandy, J. P. Schneider*. Identification of a Mechanogenetic Link between Substrate Stiffness and Chemotherapeutic Response in Breast Cancer. Biomaterials. 2019, 202: 1-11.
2018
(18.) A. Kapur, S. H. Medina, W. Wang, G. Palui, X. Ji, J. P. Schneider, H. Mattoussi*. Enhanced Uptake of Luminescent Quantum Dots by Live Cells Mediated by a Membrane-Active Peptide. ACS Omega. 2018, 3(12): 17164-17172.
(17.) M. R. Aronson°, A. W. Simonson°, L. M. Orchard, M. Llinás, S. H. Medina*. Lipopeptisomes: Anticancer Peptide-Assembled Particles for Fusolytic Oncotherapy. Acta Biomaterialia. 2018, 80(15): 269-277
(16.) A. Kapur, S. H. Medina, W. Wang, G. Palui, J. P. Schneider, H. Mattoussi*. Intracellular Delivery of Gold Nanocolloids Promoted by a Chemically Conjugated Anticancer Peptide. ACS Omega. 2018, 3(10): 12754-12762.
2017
(15.) S. H. Medina*, M. S. Michie, S. E. Miller, M. J. Schnermann, J. P. Schneider*. Fluorous Phase-Directed Peptide Assembly Affords Nano-Peptisomes Capable of Ultrasound-Triggered Cellular Delivery. Angewandte Chemie Int. Ed. 2017, 56(38): 11404-11408.
(14.) S. H. Medina*, J. P. Schneider*. Chapter 16: Chemical Ligations in the Design of Hydrogel Materials. Chemoselective and Bioorthogonal Ligation Chemistries. Wiley Publishing. 2017.
(13.) Ken Ishikawa°, S. H. Medina°, J. P. Schneider*, Amar J.S. Klar*. Glycan Alteration Imparts Cellular Resistance to a Membrane-Lytic Peptide. Cell Chemical Biology. 2017, 24(2): 149-158. Highlighted in Cell Chemical Biology.
Previous Publications
(12.) S. H. Medina, S. E. Miller, A. P. Gorka, M. J. Schnermann, J. P. Schneider*. An Intrinsically Disordered Peptide Facilitates Non-Endosomal Cell Entry. Angewandte Chemie Int. Ed., 2016, 55(10): 3369-3372. Selected by Faculty of 1000 Prime
(11.) D. J. Smith, G. A. Brat, S. H. Medina, Dedi Tong, Yong Huang, Johanna Grahammer, Georg J Furtmüller, Byoung Chol Oh, Katelyn J Nagy-Smith, Piotr Walczak, Gerald Brandacher*, Joel P Schneider*. A Multi-Phase Transitioning Peptide Hydrogel for Suturing Ultra-Small Vessels. Nature Nanotechnology, 2016, 11(1): 95-102. Highlighted in Science Daily and Phys.Org.
(10.) S. H. Medina, J. P. Schneider*. Cancer Cell Surface Induced Peptide Folding Allows Intracellular Translocation of Drug. Journal of Controlled Release, 2015, 209: 317-326.
(9.) S. H. Medina°, S. Li°, O. M. Z. Howard, M. Dunlap, A. Trivett, J. J. Oppenheim*, J. P. Schneider*. Enhanced Immunostimulatory Effects of DNA-Encapsulated Peptide Hydrogels. Biomaterials, 2015, 53: 545-553.
(8.) C. Micklitsch, S. H. Medina, T. Yucel, K. J. Nagy-Smith, D. J. Pochan, J. P. Schneider*. Influence of hydrophobic face amino acids on the hydrogelation of β-Hairpin Peptide Amphiphiles. Macromolecules, 2015, 48(5): 1281-1288.
(7.) S. Biswas, S. H. Medina, J. J. Barchi*. Synthesis and Cell-Selective Antitumor Properties of Amino Acid Conjugated Tumor-Associated Carbohydrate Antigen-Coated Gold Nanoparticles. Carbohydrate Research, 2014, 405: 93-101.
(6.) M. C. Giano, Z. Ibrahim, S. H. Medina, K. A. Sarhane, J. M. Christensen, Y. Yamada, G. Brandacher, J. P. Schneider*. Injectable bioadhesive hydrogels with innate antibacterial properties. Nature Communications, 2014, 5: 4095.
(5.) C. J. Wallace°, S. H. Medina°, M. E. H. ElSayed*. Effect of Rhamnolipids on Permeability Across Caco-2 Cell Monolayers. Pharmaceutical Research, 2013, 31(4): 887-894.
(4.) S. H. Medina, M. Chevliakov, G. Tiruchinapally, Y. Y. Durmaz, S. P. Kuruvilla, M. E. H. ElSayed. Enzyme-activated nanoconjugates for tunable release of doxorubicin in hepatic cancer cells. Biomaterials, 2013, 34(19): 4655-4666.
(3.) S. H. Medina, G. Tiruchinapally, M. V. Chevliakov, Y. Y. Durmaz, R. N. Stender, W. D. Ensminger, D. S. Shewach, M. E. H. ElSayed. Targeting Hepatic Cancer Cells with PEGylated Dendrimers Displaying N-Acetylgalactosamine and SP94 Peptide Ligands. Advanced Healthcare Materials, 2013, 2(10): 1337-1350. Highlighted in Science Translational Medicine and Medscape.
(2.) S. H. Medina, V. Tekumalla, M. V. Chevliakov, D. S. Shewach, W. D. Ensminger, M. E. H. El-Sayed*. N-acetylgalactosamine-functionalized dendrimers as hepatic cancer cell-targeted carriers. Biomaterials, 2011, 32(17): 4118-4129.
