Ye Q, Apsley AT, Hastings WJ, Etzel L, Newschaffer C, Shalev I (2024). Parental age at birth, telomere length, and autism spectrum disorders in the UK Biobank cohort. Autism Research. https://doi.org/10.1002/aur.3258
Etzel L, Apsley AT, Hastings WJ, Ye Q, Shalev I (2024). Early life adversity is associated with differential gene expression in immune cells: A cluster-based analysis across an acute psychosocial stressor. Brain, Behavior and Immunity. Apr 23:S0889-1591(24)00384-2. doi: 10.1016/j.bbi.2024.04.035.
Hastings WJ, Ye Q, Wolf SE, Ryan CP, Das SK, Huffman KM, Kobor MS, Kraus WE, MacIsaac JL, Martin CK, Racette SB, Redman LM, Belsky DW, Shalev I (2024). Effect of long-term caloric restriction on telomere length in healthy adults: CALERIE™ Trial Analysis. Aging Cell. doi: 10.1111/acel.14149
Wolf SE, Hastings WJ, Ye Q, Etzel L, Apsley AT, Chiaro C, Heim CM, Heller T, Noll JG, Schreier HMC, Shenk CE, Shalev I. Cross-tissue comparison of telomere length and metrics of DNA integrity, quality, and quantity among individuals aged 8 to 70 years. PLoS ONE. 2024 Feb 22;19(2):e0290918. https://doi.org/10.1371/journal.pone.0290918
Etzel L, Garrett-Peters P, Shalev I. Early origins of health and disease risk: The case for investigating adverse exposures and biological aging in utero, across childhood, and into adolescence. Child Development Perspectives. 2023. https://doi.org/10.1111/cdep.12488
Apsley AT, Lee SA, Bhat AC, Rush J, Almeida DM, Cole SW, Shalev I. Affective reactivity to daily stressors and immune cell gene expression in the MIDUS study. Brain, Behavior and Immunity. 2023 Oct 3:S0889-1591(23)00289-1. doi: 10.1016/j.bbi.2023.09.025
Ye Q, Apsley AT, Etzel L, Hastings WJ, Kozlosky J, Walker C, Wolf SE, Shalev I. Telomere length and chronological age across the human lifespan: a systematic review and meta-analysis of 414 study samples including 743,019 individuals. Ageing Research Reviews. 2023 Sep:90:102031. https://doi.org/10.1016/j.arr.2023.102031
Apsley AT, Ye Q, Etzel L, Wolf SE, Hastings WJ, Mattern BC, Siegel SR, Shalev I. Biological stability of DNA methylation measurements over varying intervals of time and in the presence of acute stress. Epigenetics. 2023 Dec;18(1):2230686. doi.org/10.1080/15592294.2023.2230686
Wolf SE and Shalev I. The shelterin protein expansion of telomere dynamics: linking early life adversity, life history, and the hallmarks of aging. Neuroscience & Biobehavioral Reviews. 2023 May 31;105261. doi: 10.1016/j.neubiorev.2023.105261.
Apsley AT, Etzel L, Hastings WJ, Heim CM, Noll JG, O’Donnell KJ, Schreier HMC, Shenk CE, Ye Q, Shalev I. Investigating the effects of maltreatment and acute stress on the concordance of blood and DNA methylation methods of estimating immune cell proportions. Clinical Epigenetics. 2023 Feb 28;15(1):33. https://doi.org/10.1186/s13148-023-01437-5
Waziry R, Ryan CP, Corcoran DL, Huffman KM, Kobor MS, Kothari M, Graf GH, Kraus VB, Kraus WE, Lin DTS, Pieper CF, Ramaker ME, Bhapkar M, Das SK, Ferrucci L, Hastings WJ, Kebbe M, Parker DC, Racette SB, Shalev I, Schilling B, Belsky DW. Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults: CALERIE™ Trial analysis. Nature Aging. 2023 Mar;3(3):248-257. https://doi.org/10.1038/s43587-022-00357-y
Etzel L, Apsley AT, Mattern BC, Hastings WJ, Heller T, Ram N, Siegel SR, Shalev I. Immune cell dynamics in response to an acute laboratory stressor: a within-person between-group analysis of the biological impact of early life adversity. Stress. 2022 Nov 21;25(1):347-356. doi: 10.1080/10253890.2022.2148100
Etzel L, Hastings WJ, Hall MA, Heim CM, Meaney MJ, Noll JG, O’Donnell KJ, Pokhvisneva I, Rose EJ, Schreier HMC, Shenk CE, Shalev I. Obesity and accelerated epigenetic aging in a high-risk cohort of children. Scientific Reports. 2022 May 18;12(1):8328. doi: 10.1038/s41598-022-11562-5
Hastings WJ, Etzel L, Heim CM, Noll JG, Rose EJ, Schreier HMC, Shenk CE, Tang X, Shalev I. Comparing qPCR and DNA methylation-based measurements of telomere length in a high-risk pediatric cohort. Aging (Albany NY). 2022 Jan 24;14 https://doi.org/10.18632/aging.203849
Hastings WJ, Eisenberg DTA, Shalev I. Impact of amplification efficiency approaches on telomere length measurement via qPCR. Frontiers in Genetics. 2021 Sep 17;12:728603. doi: 10.3389/fgene.2021.728603.
Hastings WJ, Almeida DM, Shalev I. Conceptual and analytical overlap between allostatic load and systemic biological aging measures: Analyses from the National Survey of Midlife Development in the United States. The Journals of Gerontology: Series A. 2022 Jun 1;77(6):1179-1188. doi: 10.1093/gerona/glab187.
Schreier HMC, Heim CM, Rose EJ, Shalev I, Shenk CE, Noll JG. Assembling a cohort for in-depth, longitudinal assessments of the biological embedding of child maltreatment: Methods, complexities, and lessons learned. Development and Psychopathology. 2021 May;33(2):394-408. doi: 10.1017/S0954579420001510.
Tollenaar MS, Beijers R, Garg E, Nguyen TT, Lin DT, MacIsaac JL, Shalev I, Kobor MS, Meaney MJ,. O’Donnell KJ, de Weerth C. Internalizing symptoms associate with the pace of epigenetic aging in childhood. Biological Psychology. 2021 Feb;159:108021. doi: 10.1016/j.biopsycho.2021.108021.
Etzel LC and Shalev I. Effects of psychological stress on telomeres as genome regulators. In Handbook of Stress Volume 4: Stress Genetics, Epigenetics, Genomics (pp. 109-117). Ed. George Fink. Elsevier (2021).
Hastings WJ, Eisenberg DTA, Shalev I. Uninterruptible power supply improves precision and external validity of telomere length measurement via qPCR. Experimental Results. Volume 1, 2020, e52. doi: https://doi.org/10.1017/exp.2020.58
Etzel L, Hastings WJ, Mattern BC, Oxford ML, Heim C, Putnam FW, Noll JG, Shalev I. Intergenerational transmission of childhood trauma? Testing cellular aging in mothers exposed to sexual abuse and their children. Psychoneuroendocrinology. 2020 Jun 27;120:104781. doi: 10.1016/j.psyneuen.2020.104781..
Shalev I, Hastings WJ, Etzel L, Israel S, Russell MA, Hendrick KA, Zinobile M, Siegel SR. Investigating the impact of early-life adversity on physiological, immune, and gene expression responses to acute stress: A pilot feasibility study. PLoS ONE. 2020 Apr 3;15(4):e0221310. doi: 10.1371/journal.pone.0221310.
Beijers R, Hartman S, Shalev I, Hastings WJ, Mattern B, de Weerth C, Belsky J. Testing three hypotheses about effects of sensitive-insensitive parenting on telomeres. Developmental Psychology. 2020 Feb;56(2):237-250. doi: 10.1037/dev0000879
Beijers R, Daehn D, Shalev I, Belsky J, de Weerth C. Biological embedding of maternal postpartum depressive symptoms: The potential role of cortisol and telomere length. Biological Psychology. 2019 Nov 14:107809. https://doi.org/10.1016/j.biopsycho.2019.107809
Hastings WJ, Shalev I, Belsky DW. Comparability of biological aging measures in the National Health and Nutrition Examination Study, 1999-2002. Psychoneuroendocrinology. (2019) Volume 106, Pages 171-178. https://doi.org/10.1016/j.psyneuen.2019.03.012.
Shalev I. and Hastings WJ. Psychosocial stress and telomere regulation. In Miu AC, Homberg JR, & Lesch KP (Eds). Genes, brain, and emotions: Interdisciplinary and Translational Perspectives. 2019. Oxford, UK: Oxford University Press. ISBN: 9780198793014
Hastings WJ, Chang A-M, Ebstein RP, Shalev I. Neuroendocrine stress response is moderated by sex and sex hormone receptor polymorphisms. Hormones and Behavior. 2018 Oct 6. doi: 10.1016/j.yhbeh.2018.10.002.
Hastings WJ, Shalev I, Belsky DW. Translating measures of biological aging to test effectiveness of geroprotective interventions: What can we learn from research on telomeres? Frontiers in Genetics. 2017 November. 8:164. doi: 10.3389/fgene.2017.00164
Belsky DW, Huffman KM, Peiper KF, Shalev I, Kraus WE. Change in the rate of biological aging in response to caloric restriction: CALERIE Biobank Analysis. The Journals of Gerontology: Series A. 2017 May. DOI: https://doi.org/10.1093/gerona/glx096
Brody GH, Yu T, Shalev I. Risky family processes prospectively forecast telomere length with mediation through negative emotions. Health Psychology. 2016 Nov. http://dx.doi.org/10.1037/hea0000443
Belsky J*, Shalev I*. Contextual adversity, telomere erosion, pubertal development and health: Two models of accelerated aging—or one? Development and Psychopathology. 2016 Nov;28(4pt2):1367-1383. *These authors contributed equally to this work.
Shalev I, Heim CM, Noll JG. Child maltreatment as a root cause of mortality disparities: a call for rigorous science to mobilize public investment in prevention and treatment. JAMA Psychiatry. 2016 Sep 1;73(9):897-8.
Shalev I and Belsky J. Early-life stress and reproductive cost: A two-hit developmental model of accelerated aging? Medical Hypotheses. 2016 March; 90:41-7. doi:10.1016/j.mehy.2016.03.002
Yim OS, Zhang X, Shalev I, Monakhov M, Zhong S, Hsu M, Chew SH, Lai PS, Ebstein RP. Delay discounting, genetic sensitivity, and leukocyte telomere length. PNAS. 2016 Feb 22. pii: 201514351.
Shalev I, Caspi A, Ambler A, Belsky DW, Chapple S, Cohen HJ, Israel S, Poulton R, Ramrakha S, Rivera CD, Sugden K, Williams B, Wolke D, Moffitt TE. Perinatal complications and aging indicators by midlife. Pediatrics. 2014 Oct 27. doi: 10.1542/peds.2014-1669. PMCID pending, NIHMSID # 638965. #Commentary by Alan Guttmacher, director of NICHD, “The Child Is Father of the Man, and Mother of the Woman“. Pediatrics. 2014 Oct. DOI: 10.1542/peds.2014-2646.
Belsky DW, Shalev I, Sears MR, Hancox RJ, Harrington H, Houts RM, Moffitt TE, Sugden K, Williams B, Poulton R, Caspi A. Is chronic asthma associated with leukocyte telomere length at midlife? American Journal of Respiratory and Critical Care Medicine. 2014 Aug 15; 190(4):384-91. #Editorial by S Guerra “New Asthma Biomarkers: Shorter Telomeres, Longer Disease?” American Journal of Respiratory and Critical Care Medicine, 190(4):356-358, 2014.
Shalev I, Moffitt TE, Braithwaite AW, Danese A, Fleming NI, Goldman-Mellor S, Harrington H, Houts RM, Israel S, Poulton R, Robertson SP, Sugden K, Williams B, Caspi A. A. Internalizing disorders and leukocyte telomere erosion: a prospective study of depression, generalized anxiety disorder and post-traumatic stress disorder. Molecular Psychiatry, advance online publication, (2014) Jan; doi:10.1038/mp.2013.183. #Supplementary information
Shalev I and Ebstein RP (Eds.). Social hormones and human behavior: What do we know and where do we go from here. Frontiers in Neuroscience. ISSN 1664-8714. ISBN 978-2-88919-407-0. DOI: 10.3389/978-2-88919-407-0 (2015).
Meier M,* Shalev I*, Moffitt TE, Kapur S, Keefe R, Wong T, Belsky DW, Harrington H, Hogan S, Houts R, Caspi A, Poulton R. Retinal Imaging Reveals Microvascular Abnormalities in Schizophrenia. American Journal of Psychiatry (2013) Sep. doi:10.1176/appi.ajp.2013.
13020234. *These authors contributed equally to this work.
Shalev I, Entringer S, Wadhwa PD, Wolkowitz OM, Puterman E, Lin J, Epel ES. Stress and Telomere Biology: A Lifespan Perspective. Psychoneuroendocrinology (2013) Apr. doi: 10.1016/j.psyneuen.2013.03.010.
Shalev I, Moffitt TE, Wong TY, Meier MH, Houts RM, Ding J, Cheung CYL, Ikram MK, Caspi A, Poulton R. Retinal vessel caliber and lifelong neuropsychological functioning: an investigative tool for cognitive epidemiology. Psychological Science (2013) Jul 1;24(7):1198-207. doi: 10.1177/0956797612470959.
Edelman S*, Shalev I*, Uzefovsky F, Israel S, Knafo A, Kremer I, Kaitz M, Ebstein RP. Epigenetic and genetic factors predict women’s salivary cortisol following a threat to the social self. PLoS ONE (2012) Nov. 7(11): e48597. doi:10.1371/journal.pone.0048597. *These authors contributed equally to this work.
Shalev I. Early life stress and telomere length: investigating the connection and possible mechanisms: A critical survey of the evidence base, research methodology and basic biology. BioEssays (2012) Sep 19. 34(11):943-52. doi: 10.1002/bies.201200084.
Shalev I, Moffitt TE, Sugden K, Williams B, Houts RM, Danese A, Mill J, Arseneault L, Caspi A. Exposure to violence during childhood is associated with telomere erosion from 5 to 10 years of age: a longitudinal study. Molecular Psychiatry (2013) 18, 576-581. doi:10.1038/mp.2012.32
Shalev I, Israel S, Uzefovsky F, Gritsenko I, Kaitz M, Ebstein RP. Vasopressin needs an audience: neuropeptide elicited stress responses are contingent upon perceived social evaluative threats. Hormones and Behavior (2011) Jun;60(1):121-7.
Shalev I, Lerer E, Israel S, Uzefovsky F, Gritsenko I, Mankuta D, Ebstein RP, Kaitz M. BDNF Val66Met polymorphism is associated with HPA axis reactivity to psychological stress characterized by genotype and gender interactions. Psychoneuroendocrinology (2009) Apr;34(3):382-8.